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Name: _______________________KEY_______________________________ Date: ____________________
Directions: Match the following vocabulary words.
- ___D____ messenger RNA A. Product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease
- _ __C____ Vaccine Engineering B. Molecules capable of stimulating an immune response, with each having distinct surface features (or epitopes) resulting in specific responses
- ___F____ Adenovirus-Based Vaccine
- ___A____ Vaccine
C. Approach to discover novel antigens, epitopes, and adjuvants that can stimulate and manipulate the immune system, as well as their targeted delivery, for the prevention and treatment of important diseases such as cancer and infectious diseases
- ___G____ Adjuvants
D. Vaccine method that instructs immune cells to make copies of the COVID-19 spike protein, acting as if the cells have been infected with the coronavirus
- ___B____ Antigen E. A therapy’s tendency to trigger an unwanted immune response against themselves
- ___H____ Antibody F. Vaccine method that uses non-enveloped, double-stranded DNA viruses
- _ __E____ Immunogenicity
G. Components capable of enhancing and/or shaping antigen-specific immune responses
H. (also known as immunoglobulins) Y- shaped proteins that have the ability to recognize and bind to antigens
Directions: Label following steps from (1-6) in the order of the general vaccine
development process as given by the CDC.
- ___ 3 ___ _ Clinical development (3 Phase Process)
- ___2____ Pre-clinical stage
- _ __5____ Manufacturing
- ___6____ Quality control
- _ __4____ Regulatory review and approval
- ___1____ Exploratory stage
Directions: Multiple Choice - Circle the choice that best answers the question.
- What does the preclinical stage involve?
a. Tissue-culture or cell-culture systems b. Small groups of adults c. Animal testing d. Basic laboratory research e. a, c f. a, c, d g. All of the above
The allocation of the vaccine should shift depending on the...
a. Supply b. Demand c. Vaccine characteristics d. Disease epidemiology e. All of the above f. None of the above
- Name THREE sources of funding.
National Institutes of Health (NIH):
● multi-PI grants ● PPG ● NCRR ● RFAs ● Contracts (IEDB)
Pharmaceutical Industry:
● Research contracts ● Licensing
Biotech Industry:
● Funding for IP ● Startups ● Angel investors ● Venture capitalist companies
- What are TWO risks of the SARS/COVID-19 Vaccine?
The SARS/COVID-19 Vaccine comes with the potential issues of:
● Antibody-dependent enhancement (ADE), in which a vaccine may actually worsen the consequences of the disease rather than protect ● Those most at risk are over 60, but resistance to vaccination begins as early as 30 ● May reduce the chance of getting the disease (and its symptoms) but not prevent infection ● New variants being less susceptible
- Why might allocation disparities occur?
● There are different circumstances and situations ● Federal, states, and local health departments as well as medical centers have each developed different allocation formulas, based on a variety of ethical and political considerations ● Some areas may have greater numbers of a certain population, such as there being more elderly than educators
