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Use of Prophylactic Fluconazole, Fungal Infections, Case Mortality Rates, Antifungal Prophylaxis, Intra-Abdominal Involvement, Eye Involvement, Factors for Candidiasis, Central Line Placement. The word pediatrics and its cognates mean healer of children; they derive from two Greek words: παῖς (pais = child) and ἰατρός (iatros = doctor or healer). THis is one of lectures on Paediatrics. Main points are give above.
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*adapted from Healy,M: NeoReviews, 2008
RCTs of fluconazole prophylaxis in neonates
Study Enrolment Criteria
N Protocol Dosing Schedule Treatment Group (IC)
Control Group (IC)
P-value
Kaufman et al (2001)
<1000 g ETT or CVC ≤ 5 days of life
100 Single-centre placebo
3mg/kg x 6 wks or less if no IV needed q72h (0-14d) q48h (15-28d) q24h (29-42d)
(4 Candida- related deaths)
Kicklighter et al (2001)
<1500 g ≤ 3 days of life
103 Single-centre placebo
6 mg/kg IV/PO For 28 days
(1 Candida- related death)
Cabrera et al (2002)
<1500 g 11 Single-centre, placebo
6 mg/kg IV then PO 0/6 1/5 NS
Parikh et al (2007)
<1500 g 120 Single-centre, placebo
6 mg/kg IV then po for 28 days
Manzoni et al (2007)
<1500 g ≤ 3 days of life
322 Multi-centre, placebo
6 mg/kg or 3 mg/kg qod x 30d (100- 1500g) or 45d (<1000g) or less if no IV needed
(0 Candida- related deaths)
(4 Candida- related deaths)
HIGH (eg: >5%)