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Types of Drug Therapy Research Papers, Lecture notes of Clinical Medicine

The types of drug therapy research papers that are of interest to clinical pharmacists. It highlights the importance of critical appraisal and the ability to judge the scientific value of research papers. The main aim is to determine whether a paper, in conjunction with other relevant literature and clinical experience, should change clinical practice. The document also provides a list of questions to consider when choosing a paper for critical appraisal.

Typology: Lecture notes

2021/2022

Available from 02/19/2023

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Types of Drug Therapy Research Papers:
The studies of greatest interest to clinical pharmacists includes the
following points:
1. Focus on clinical efficacy
2. Short- and/or long- term drug toxicity
3. Drug pharmacokinetics
4. Dose-response relationships
5. Drug Therapy Monitoring
What is critical appraisal:
It is the ability to read original research papers in a way that
allows us to judge their scientific value and to consider how the
results can be applied in practice.
Main aim: should this paper, in conjunction with other relevant
literature and clinical experience, change the clinical practice?
Choosing a paper for Critical Appraisal:
Is this paper addressing an important or controversial
therapeutic issue which is of relevance to my patients?
Is this study the first evidence for the efficacy of a new drug class or
treatment?
Does this study involve more patients or is it continued for
longer than previous studies?
Is the studied population different in any way from previous
studies?
Does the methodology address the methodological
problems identifies in previous studies of this drug?
pf2

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Types of Drug Therapy Research Papers:

The studies of greatest interest to clinical pharmacists includes the following points:

  1. Focus on clinical efficacy
  2. Short- and/or long- term drug toxicity
  3. Drug pharmacokinetics
  4. Dose-response relationships
  5. Drug Therapy Monitoring What is critical appraisal: It is the ability to read original research papers in a way that allows us to judge their scientific value and to consider how the results can be applied in practice. Main aim : should this paper, in conjunction with other relevant literature and clinical experience, change the clinical practice? Choosing a paper for Critical Appraisal:  Is this paper addressing an important or controversial therapeutic issue which is of relevance to my patients?  Is this study the first evidence for the efficacy of a new drug class or treatment?  Does this study involve more patients or is it continued for longer than previous studies?  Is the studied population different in any way from previous studies?  Does the methodology address the methodological problems identifies in previous studies of this drug?

Hierarchy of evidence

I. Systematic Reviews and Meta-analysis

II. Randomised Controlled trials

III. Non-Randomised controlled trials

IV. Cohort studies

V. Case-control studies

VI. Cross-sectional surveys

VII. Case reports