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Biology of Large Molecules: Carbohydrates, Lipids, and Proteins - Prof. Laurie A. Host, Study notes of Biology

An overview of the four major classes of biological molecules: carbohydrates, lipids, and proteins. It covers the structure, functions, and synthesis of monosaccharides, polysaccharides, single sugars, fats, fatty acids, phospholipids, steroids, amino acids, and proteins. The text also explains the differences between storage and structural polysaccharides, the role of lipids in energy storage and cell membranes, and the importance of proteins in cellular functions.

Typology: Study notes

Pre 2010

Uploaded on 08/16/2009

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Chapter 5
The Molecules of Life
Overview
All living things are made up of four classes of
large biological molecules:
______________are large molecules compo sed
of thousands of covalently connected atoms
A __________ is a long molecule consisting of
many similar building blocks
These small building-block molecules are called
____________.
The synthesis and breakdown of polymers
Carbohydrates serve as fuel and
building material
The simplest carbohydrates are_____________,
or single sugars
Carbohydrate macromolecules are
____________, polymers composed of many
sugar building blocks
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Chapter 5

The Molecules of Life

Overview

  • All living things are made up of four classes of large biological molecules:
  • ______________are large molecules composed of thousands of covalently connected atoms
  • A __________ is a long molecule consisting of many similar building blocks
  • These small building-block molecules are called ____________. The synthesis and breakdown of polymers

Carbohydrates serve as fuel and

building material

  • The simplest carbohydrates are_____________, or single sugars
  • Carbohydrate macromolecules are ____________, polymers composed of many sugar building blocks

Single Sugars

  • Monosaccharides have molecular formulas that are usually multiples of CH 2 O
  • ___________ (C 6 H 12 O 6 ) is the most common
  • Monosaccharides are classified by
    • The location of the ____________ group
    • The number of carbons
  • Monosaccharides serve as a major fuel for cells and as raw material for building molecules The structure and classification of some monosaccharides Linear and ring forms of glucose
  • A _____________ is formed when a dehydration reaction joins two monosaccharides
  • Polymers with glucose are

  • Polymers with glucose are
     - H atoms on one strand can bond with OH groups on other strands 

Lipids are a diverse group of

hydrophobic molecules

  • Lipids do not form polymers
  • Little or no affinity for water
  • Lipids are hydrophobic because they consist mostly of hydrocarbons, which form ___________________bonds

Fats

  • Constructed from two types of smaller molecules:
  • _________ is a three-carbon alcohol with a hydroxyl group attached to each carbon
  • ______________consists of a carboxyl group attached to a long carbon skeleton The synthesis and structure of a fat, or triacylglycerol
  • Fatty acids vary in length and in the number and locations of double bonds
  • ___________have the maximum number of hydrogen atoms possible and no double bonds
  • _____________ have one or more double bonds Examples of saturated and unsaturated fats and fatty acids
  • The major function of fats is____________
  • Humans and other mammals store their fat in
  • Cushions vital organs and insulates the body

Phospholipids

  • A phospholipid is composed of:

Polypeptides

  • Polymers built from the same set of 20 amino acids
  • A _________ consists of one or more polypeptides
  • Amino acids have: The 20 amino acids of proteins

Amino Acid Polymers

  • Amino acids are linked by _____________
  • Polypeptides range in length
  • Each polypeptide has a unique linear sequence of amino acids Making a polypeptide chain

Protein Structure and Function

  • A functional protein consists of one or more polypeptides twisted, folded, and coiled into a unique shape
  • Structure is determined by:
  • A protein’s structure determines its:
    • The sequence of amino acids in a protein
    • Primary structure is determined by:
  • The coils and folds result from hydrogen bonds
  • Typical secondary structures are a coil called an ___________and a folded structure called a _________________.
  • ________________is determined by interactions between R groups, rather than interactions between backbone constituents
  • These interactions between R groups include:
  • Strong covalent bonds called _______________may reinforce the protein’s structure
  • Quaternary structure results when:

Nucleic acids store and transmit

hereditary information

  • The amino acid sequence of a polypeptide is programmed by a unit of inheritance called a ________.
  • There are two types of nucleic acids:
  • DNA provides directions for its own replication
  • DNA directs synthesis of messenger RNA (mRNA) and, through mRNA, controls:

The Structure of Nucleic Acids

  • Nucleic acids are polymers called ____________.
  • Made of monomers called _____________.

Nucleotide Monomers

  • Nucleoside =
  • There are two families of nitrogenous bases: - Pyrimidines - Purines
  • In DNA, the sugar is ___________ ; in RNA, the sugar is _________.
  • Nucleotide = nucleoside + phosphate group

The DNA Double Helix

  • A DNA molecule has two polynucleotides spiraling around an imaginary axis, forming a _____________.
  • In the DNA double helix, the two backbones run in opposite directions from each other, an arrangement referred to as _____________.