The Dorsal Tongue
Cancer and Other Maladies
James J. Sciubba, DMD, PhD
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Anatomy and Physiology of the Tongue: Papillae, Taste Buds, and Diseases, Slides of Medicine
An in-depth exploration of the tongue's structure, focusing on papillae types, their functions, and the taste buds. It covers filiform, fungiform, and circumvallate papillae, their filaggrins, nerve supply, and functions. The document also discusses diseases and conditions affecting the tongue, such as lichen planus, amyloidosis, and granular cell tumors.
What you will learn
- What are the functions of filiform papillae on the tongue?
- What are the different types of papillae on the tongue and where are they located?
- What are the main causes and symptoms of lichen planus?
- What are the different types of amyloidosis and how are they diagnosed?
- How do taste buds in the tongue work?
Typology: Slides
2021/2022
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The Dorsal Tongue
Cancer and Other Maladies
James J. Sciubba, DMD, PhD
The Basics Form and Structure
- The tongue surface
- Filiform papillae
- Fungiform papillae
- Vallate papillae
- Foliate papillae
Filiform Papillae
H: hair-like S: skin- like LM: lining mucosa- like
Filiform Papillae
Anterior compartment
- Hair-like pattern of keratin differentiation
- Keratin expression: K 4, 6, 13, 16 & KHG proteins
Posterior compartment
- Skin-like keratin differentiation pattern 1, 10
Intervening area / between compartments
- Resembles lining / buccal mucosa
Filiform Papillae Further Characteristics
- Epithelial cells contain keratin-bundling proteins
- Filaggrins
- Co-localize with trichohyalin protein
- Crucial in the keratinization process
- Filaggrins
- Nerve supply
- Three types of nerve endings
- Free unmyelinated-extend to subepithelial CT
- Epithelial nerve endings-near BMZ or within basal / suprabasal cells
- Complex nerve endings-lamellar corpuscles: sensory mechanoreceptors - Spatial perception: magnified by a factor of 1:
- Three types of nerve endings
Foliate Papillae
- At posterolateral location
- Deeply folded mucosa
- Cornified surface
- Lymphoid stroma deep to surface
- Numerous taste buds along lateral walls early in life
- Atrophy later in life
Circumvallate Papillae
- 2.5 mm wide-1.0 mm deep
- Richly innervated and vascularized
- Each papilla is trenched
- flushed by von Ebner glands
- Up to 35 ducts rim the base of each papilla
- flushed by von Ebner glands
- Lateral surfaces w/ hundreds
of taste buds
The Taste Bud A Bioengineering Marvel
Taste Bud Facts
- III: contain “densities” and synaptic vesicles - vesicles contact nerve endings - Similar to type II cells
- IV: small basal cells
- Differentiate into other taste bud cells
- V: perigemmal cells
- At taste bud periphery
- Contain perigemmal nerve endings
The Lingual Follicle
- In aggregate form the lingual tonsil
- Are small lymphoepithelial organs
- Contain mucous glands opening into crypts (Cr)
- Lining is non-keratinizing
Capsule
Plate: I II III IV
Intemperance
Dental Indentations
Idiopathic Excoriations
Tertiary Syphilis
Tertiary Syphilis
Chronic Ulcer
Dental Trauma
TB
Lupus
Mucous Patch
Gummatous Ulcer
Ruptured Gumma