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Chem 3393 - Medicinal Chemistry Midterm 2014
Typology: Exams
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A) Drugs and drug targets generally have similar molecular masses. B) Drugs are generally smaller than drug targets. C) Drugs are generally larger than drug targets. D) There is no general rule regarding the relative size of drugs and their targets.
adrenaline
estrone
A) Adrenaline is repelled by the hydrophilic cell membrane. B) Adrenaline has a higher melting point than does estrone. C) Adrenaline is a synthetic drug, and synthetic drugs never cross membranes. D) Estrone is less polar than adrenaline.
A) hydrophobic interactions. B) covalent bonding. C) hydrogen bonding. D) dipole-dipole interactions. E) electrostatic interactions.
drug
drug
drug
drug
drug
O
A) weak base. B) binding group. C) hydrogen bonding acceptor. D) binding region. E) hydrophobic group.
left O right
A) Left B) Right C) Cannot be determined from the information given
A) It is not planar. B) It is capable of forming a hydrogen bond. C) The cis configuration is favoured over a trans configuration. D) Single-bond rotation is permitted between nitrogen and the carbonyl group.
A) intermolecular interactions and intermolecular disulfide linkages. B) intramolecular interactions and intermolecular disulfide linkages. C) intermolecular interactions and intramolecular disulfide linkages. D) intramolecular interactions and intramolecular disulfide linkages.
glycine
A) decreasing the energy of the substrate and increasing the energy of the transition state. B) decreasing the energy of the substrate and decreasing the energy of the transition state. C) increasing the energy of the substrate and increasing the energy of the transition state. D) increasing the energy of the substrate and decreasing the energy of the transition state.
A) The process by which an active site alters shape such that it is ready to accept a substrate. B) The process by which a substrate adopts the correct binding conformation before entering an active site. C) The process by which a substrate binds to an active site and alters the shape of the active site. D) The process by which an active site alters the shape of the substrate such that it can adopt the necessary active conformation for binding.
Side chains: (^) Glu COOH
Asp COOH
Lys
His N
A) The side chain of glutamic acid in its neutrally charged form B) The side chain of histidine in its positively charged form C) The side chain of aspartic acid in its neutrally charged form D) The side chain of lysine in its neutrally charged form
A) Agonists are drugs that have the same effect on a receptor as the endogenous chemical messenger. B) Desensitization occurs when an agonist is bound for a long period of time. C) In the absence of anything bound to a receptor, a small amount of the receptor is in the active conformation. D) Receptors are chiral. E) Any conformational change of the receptor will cause a message to be sent.
A) Potency B) IC 50 C) Affinity D) Efficacy E) Stability
A) Converting the alcohol to a methyl ether B) Adding an extra aromatic ring to the structure C) Synthesizing an analogue which lacks the aromatic ring D) Converting the amine to an amide
A) a chain terminator. B) an alkylating agent. C) an intercalating agent. D) a topoisomerase poison.
A) cause themselves to stack between the base pairs. B) stabilize the nicked DNA-topoisomerase complex. C) lead to interstrand or intrastrand crosslinking. D) directly inhibit DNA polymerase.
A) binding to, and activating, the serotonin receptor. B) binding to, and inhibiting, the serotonin pump. C) binding to, and deactivating, the serotonin receptor. D) binding to, and inhibiting, the enzyme that makes serotonin.
A) a hydrophobic interior and a hydrophobic exterior. B) a hydrophobic interior and a hydrophilic exterior. C) a hydrophilic interior and a hydrophilic exterior. D) a hydrophilic interior and a hydrophobic exterior.
End of multiple-choice section
glutamine
arginine
lactate
malate
quinazoline
HO Tyr
HO Tyr
analogue 1
analogue 2
A) Drugs and drug targets generally have similar molecular masses. B) Drugs are generally smaller than drug targets. C) Drugs are generally larger than drug targets. D) There is no general rule regarding the relative size of drugs and their targets.
adrenaline
estrone
A) Adrenaline is repelled by the hydrophilic cell membrane. B) Adrenaline has a higher melting point than does estrone. C) Adrenaline is a synthetic drug, and synthetic drugs never cross membranes. D) Estrone is less polar than adrenaline.
A) hydrophobic interactions. B) covalent bonding. (covalent bonding is not an intermolecular interaction) C) hydrogen bonding. D) dipole-dipole interactions. E) electrostatic interactions.
drug
drug
drug
drug
drug
O
D (hydrophobic “forces” are due to the displacement of water)
A) weak base. B) binding group. C) hydrogen bonding acceptor. D) binding region. E) hydrophobic group.
left O right
A) Left B) Right (look for an α-carbon and see which side the N is on) C) Cannot be determined from the information given
A) It is not planar. B) It is capable of forming a hydrogen bond. C) The cis configuration is favoured over a trans configuration. D) Single-bond rotation is permitted between nitrogen and the carbonyl group.
A) intermolecular interactions and intermolecular disulfide linkages. B) intramolecular interactions and intermolecular disulfide linkages. C) intermolecular interactions and intramolecular disulfide linkages. D) intramolecular interactions and intramolecular disulfide linkages.
glycine
A) decreasing the energy of the substrate and increasing the energy of the transition state. B) decreasing the energy of the substrate and decreasing the energy of the transition state. C) increasing the energy of the substrate and increasing the energy of the transition state. D) increasing the energy of the substrate and decreasing the energy of the transition state.
A) The process by which an active site alters shape such that it is ready to accept a substrate. B) The process by which a substrate adopts the correct binding conformation before entering an active site. C) The process by which a substrate binds to an active site and alters the shape of the active site. D) The process by which an active site alters the shape of the substrate such that it can adopt the necessary active conformation for binding.
Side chains: (^) Glu COOH
Asp COOH
Lys
His N
A) The side chain of glutamic acid in its neutrally charged form B) The side chain of histidine in its positively charged form C) The side chain of aspartic acid in its neutrally charged form D) The side chain of lysine in its neutrally charged form
A) Agonists are drugs that have the same effect on a receptor as the endogenous chemical messenger. B) Desensitization occurs when an agonist is bound for a long period of time. C) In the absence of anything bound to a receptor, a small amount of the receptor is in the active conformation. D) Receptors are chiral. E) Any conformational change of the receptor will cause a message to be sent. (must be a correct conformational change)
A) Potency B) IC 50 C) Affinity D) Efficacy E) Stability
A) Converting the alcohol to a methyl ether B) Adding an extra aromatic ring to the structure C) Synthesizing an analogue which lacks the aromatic ring D) Converting the amine to an amide
A) a chain terminator. (no 3’-OH) B) an alkylating agent. C) an intercalating agent. D) a topoisomerase poison.
A) cause themselves to stack between the base pairs. B) stabilize the nicked DNA-topoisomerase complex. C) lead to interstrand or intrastrand crosslinking. D) directly inhibit DNA polymerase.
A) binding to, and activating, the serotonin receptor. B) binding to, and inhibiting, the serotonin pump. C) binding to, and deactivating, the serotonin receptor. D) binding to, and inhibiting, the enzyme that makes serotonin.
A) a hydrophobic interior and a hydrophobic exterior. B) a hydrophobic interior and a hydrophilic exterior. C) a hydrophilic interior and a hydrophilic exterior. D) a hydrophilic interior and a hydrophobic exterior.
End of multiple-choice section