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Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity. It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties. Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform and acetone. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%.
Typology: Study notes
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Chlorobutanol is highly toxic to the liver, is a skin irritant and a severe eye irritant
Structu re C4H7Cl3O
Synthesis Chlorobutanol was first synthesized in 1881 by the German chemist Conrad Willgerodt (1841–1930). Chlorobutanol is formed by the reaction of chloroform and acetone in the presence of potassium or sodium hydroxide. It may be purified by sublimation or recrystallisation
Mechanism of reaction
● (^) Sedative, hypnotic and in motion sickness ● (^) It also local antiseptic too
Expert advice for Chlorobutanol Cream:
_1. Avoid contact with eyes