SIGNAL TRANSDUCTION CAMP WITH
CORRECT ANSWERS
step 1: Ligand binds (Reception) - CORRECT ANSWER-ligand
binds to the G-protein Coupled Receptor (GPCR).
step 2: GPCR is activated
(Reception) - CORRECT ANSWER-binding of the ligand
(hormone) activates the GPCR.
step 3: GPCR binds to G protein
(Transduction) - CORRECT ANSWER-active GPCR is able to
bind the G-protein
step 4: G protein activated (Transduction) - CORRECT
ANSWER-G-protein ejects a GDP accepts a GTP
G-protein=active
step 5: G protein splits
(Transduction) - CORRECT ANSWER-G-protein α subunit with
GTP disassociates from the β and γ subunits
Step 6: Activate Adenylyl cyclase
(Transduction) - CORRECT ANSWER-α subunit with GTP goes
to adenylyl cyclase and activates it
Step 7: ATP to Cyclic AMP
(Transduction) - CORRECT ANSWER-active adenylyl cyclase
transforms ATP into cAMP
