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Ramipril AN: Uses, Dosage, Side Effects, and Precautions, Lecture notes of Medicine

Information on ramipril an, a medication used to treat high blood pressure, heart conditions, and kidney problems. It explains how ramipril an works, its benefits, and the risks involved. The document also covers the importance of discussing with a doctor before taking ramipril an, potential interactions with other medicines, and the proper dosage and administration. It concludes with a list of side effects and precautions.

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Ramipril AN Tablets
Ramipril
Consumer Medicine Information
Ramipril AN Tablets Published by MIMS November 2014 1
What is in this leaflet
This leaflet answers some common questions
about Ramipril AN.
It does not contain all the available information.
It does not take the place of talking to your doctor
or, pharmacist.
All medicines have risks and benefits. Your
doctor has weighed the risks of you taking
Ramipril AN against the benefits it is expected to
have for you.
If you have any concerns about taking this
medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again
What Ramipril AN is used for
Ramipril AN belongs to a group of medicines
called angiotensin converting enzyme (ACE)
inhibitors.
Ramipril AN is used to treat:
high blood pressure (hypertension)
some heart conditions such as heart failure
after a heart attack
kidney problems in some patients
Ramipril AN is also used to reduce the risk of
cardiovascular problems and complications in
patients aged 55 years or more with heart or
blood vessel disease, or diabetes.
Hypertension
Ramipril AN is used to lower high blood pressure
(hypertension). Everyone has blood pressure.
This pressure helps get your blood all around
your body. Your blood pressure may be different
at different times of the day and can be influenced
by how busy or worried you are. You have
hypertension when your blood pressure stays
higher than is needed, even when you are calm
and relaxed.
There are usually no symptoms of hypertension.
The only way of knowing that you have
hypertension is to have your blood pressure
checked on a regular basis. If high blood pressure
is not treated it can lead to serious health
problems, including stroke, heart disease and
kidney failure.
Heart Failure after a Heart Attack
Ramipril AN may be used after a heart attack. A
heart attack occurs when one of the major blood
vessels supplying blood to your heart becomes
blocked. This means that your heart muscle
cannot receive the oxygen it needs and becomes
damaged. This may lead to further problems,
such as heart failure, irregular heart rhythms and
blood clots.
Heart failure means that the heart muscle is weak
and cannot pump blood strongly enough to
supply all the blood needed throughout the body.
Heart failure is not the same as heart attack and
does not mean that the heart stops. Heart failure
may start off with no symptoms, but as the
condition progresses, patients may feel short of
breath or may get tired easily after light physical
activity such as walking. Some patients may
wake up short of breath at night. Fluid may
collect in different parts of the body, often first
noticed as swollen ankles and feet.
Kidney Problems
Ramipril AN may be used to treat some kidney
problems. Some conditions such as diabetes and
hypertension can lead to kidney problems. These
problems develop slowly over several years.
Good control of your blood sugar and blood
pressure are important in keeping your kidneys
healthy, but may not always prevent kidney
damage from occurring.
Prevention of Cardiovascular Problems and
Complications
Ramipril AN may be used to reduce the risk of
some of the problems and complications that may
arise in patients aged 55 or more who have
problems such as coronary artery disease (heart
disease caused by poor blood flow in the blood
vessels of the heart), peripheral vascular disease
(poor circulation in the hands or feet), or stroke.
Ramipril AN may also be used to reduce the risk
of cardiovascular problems and complications in
patients with diabetes aged 55 years or more who
may be considered at risk because of one or more
additional factors such as high blood pressure,
high cholesterol levels, kidney problems, a
current smoker, or previous disease of the blood
vessels.
How Ramipril AN works
Ramipril AN works by widening the blood
vessels, which reduces the pressure in the vessels,
making it easier for your heart to pump blood
around your body. This helps increase the supply
of oxygen to your heart, so that when you place
extra demands on your heart, such as during
exercise, your heart may cope better and you may
not get short of breath as easily.
By increasing the supply of oxygen to your heart,
your heart does not have to work as hard and it is
under less stress, which may reduce the risk of
further damage occurring to it following a heart
attack.
Ramipril AN also improves blood flow through
the small blood vessels found in the kidneys,
which helps the kidneys to work more efficiently.
This in turn progression of kidney damage that
might result from having diabetes or high blood
pressure.
Therefore, there are quite a few reasons why your
doctor might have decided to treat you with
Ramipril AN. Your doctor may have also
prescribed this medicine for another reason.
Ask your doctor or pharmacist if you have any
questions about why Ramipril AN has been
prescribed for you.
Ramipril AN is not addictive.
Ramipril AN is available only with a doctor's
prescription.
Before you take Ramipril AN
When you must not take it
Do not take Ramipril AN if you:
have had an allergy to Ramipril AN or any
other medicine containing ramipril, or any
of the ingredients listed at the end of this
leaflet.
Symptoms of an allergic reaction may
include skin rash, itchiness, shortness of
breath, swelling of the face, lips or tongue,
abdominal pain, muscle pain or tenderness,
or joint pain.
have taken any other "ACE inhibitor"
medicine before, which caused your face,
lips, tongue, throat, hands or feet to swell
up, or made it hard for you to breathe.
If you have had an allergic reaction to an
ACE inhibitor before, you may be allergic to
Ramipril AN
or your family have a history of swelling of
the face, lips, tongue, throat, intestines,
hands or feet, for no apparent reason.
have kidney problems or a condition
called "renal artery stenosis".
have problems or conditions affecting the
flow of blood in and out of your heart (e.g.
aortic or valvular stenosis).
have low blood pressure.
undergo dialysis using certain high-flux
membranes.
are diabetic or have kidney problems and
are being treated with aliskiren-containing
medications or a group of medicines
known as AIIRAs (a medication also used
to treat high blood pressure).
are pregnant or intend to become
pregnant.
Ramipril AN may affect your developing
baby if you take it during pregnancy.
are breastfeeding.
Ramipril AN may pass into the breast milk
and affect your breastfed baby.
Do not use Ramipril AN after the expiry date
(EXP) printed on the pack.
If you take this medicine after the expiry date has
passed, it may not work as well.
Do not use Ramipril AN if the packaging is
torn or shows signs of tampering.
Before you start to take it
Tell your doctor if you have allergies to:
any other medicines
any other substances, such as foods,
preservatives or dyes
Tell your doctor if you have or have had any
medical conditions, especially the following:
kidney problems, or are having dialysis (note
that your doctor may give you Ramipril AN
because of your kidney problems)
liver problems
heart problems (note that your doctor may
give you Ramipril AN because of your heart
problems)
low blood pressure, which you may notice as
dizziness or lightheadedness
low white blood cell counts
diabetes (note that your doctor may give you
Ramipril AN because of your diabetes)
high levels of potassium in your blood
Systemic Lupus Erythematosus (SLE),
scleroderma or other autoimmune conditions
Tell your doctor if you have a family history of
swelling of the face, lips, tongue, throat,
intestines, hands or feet.
You must also tell your doctor if you:
are following a very low or very high salt
diet
are dehydrated, or have had a recent bout of
vomiting or diarrhoea
pf3

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Ramipril AN Tablets

Ramipril

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Ramipril AN.

It does not contain all the available information. It does not take the place of talking to your doctor or, pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you taking Ramipril AN against the benefits it is expected to have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again

What Ramipril AN is used for

Ramipril AN belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors.

Ramipril AN is used to treat:

  • high blood pressure (hypertension)
  • some heart conditions such as heart failure after a heart attack
  • kidney problems in some patients

Ramipril AN is also used to reduce the risk of cardiovascular problems and complications in patients aged 55 years or more with heart or blood vessel disease, or diabetes.

Hypertension Ramipril AN is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day and can be influenced by how busy or worried you are. You have hypertension when your blood pressure stays higher than is needed, even when you are calm and relaxed.

There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure.

Heart Failure after a Heart Attack Ramipril AN may be used after a heart attack. A heart attack occurs when one of the major blood vessels supplying blood to your heart becomes blocked. This means that your heart muscle cannot receive the oxygen it needs and becomes damaged. This may lead to further problems, such as heart failure, irregular heart rhythms and blood clots.

Heart failure means that the heart muscle is weak and cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops. Heart failure may start off with no symptoms, but as the condition progresses, patients may feel short of breath or may get tired easily after light physical activity such as walking. Some patients may wake up short of breath at night. Fluid may collect in different parts of the body, often first noticed as swollen ankles and feet.

Kidney Problems Ramipril AN may be used to treat some kidney problems. Some conditions such as diabetes and hypertension can lead to kidney problems. These problems develop slowly over several years. Good control of your blood sugar and blood pressure are important in keeping your kidneys healthy, but may not always prevent kidney damage from occurring. Prevention of Cardiovascular Problems and Complications Ramipril AN may be used to reduce the risk of some of the problems and complications that may arise in patients aged 55 or more who have problems such as coronary artery disease (heart disease caused by poor blood flow in the blood vessels of the heart), peripheral vascular disease (poor circulation in the hands or feet), or stroke. Ramipril AN may also be used to reduce the risk of cardiovascular problems and complications in patients with diabetes aged 55 years or more who may be considered at risk because of one or more additional factors such as high blood pressure, high cholesterol levels, kidney problems, a current smoker, or previous disease of the blood vessels.

How Ramipril AN works

Ramipril AN works by widening the blood vessels, which reduces the pressure in the vessels, making it easier for your heart to pump blood around your body. This helps increase the supply of oxygen to your heart, so that when you place extra demands on your heart, such as during exercise, your heart may cope better and you may not get short of breath as easily. By increasing the supply of oxygen to your heart, your heart does not have to work as hard and it is under less stress, which may reduce the risk of further damage occurring to it following a heart attack. Ramipril AN also improves blood flow through the small blood vessels found in the kidneys, which helps the kidneys to work more efficiently. This in turn progression of kidney damage that might result from having diabetes or high blood pressure. Therefore, there are quite a few reasons why your doctor might have decided to treat you with Ramipril AN. Your doctor may have also prescribed this medicine for another reason. Ask your doctor or pharmacist if you have any questions about why Ramipril AN has been prescribed for you. Ramipril AN is not addictive. Ramipril AN is available only with a doctor's prescription.

Before you take Ramipril AN

When you must not take it

Do not take Ramipril AN if you:

  • have had an allergy to Ramipril AN or any other medicine containing ramipril, or any of the ingredients listed at the end of this leaflet. Symptoms of an allergic reaction may include skin rash, itchiness, shortness of breath, swelling of the face, lips or tongue, abdominal pain, muscle pain or tenderness, or joint pain. - have taken any other "ACE inhibitor" medicine before, which caused your face, lips, tongue, throat, hands or feet to swell up, or made it hard for you to breathe. If you have had an allergic reaction to an ACE inhibitor before, you may be allergic to Ramipril AN - or your family have a history of swelling of the face, lips, tongue, throat, intestines, hands or feet, for no apparent reason. - have kidney problems or a condition called "renal artery stenosis". - have problems or conditions affecting the flow of blood in and out of your heart (e.g. aortic or valvular stenosis). - have low blood pressure. - undergo dialysis using certain high-flux membranes. - are diabetic or have kidney problems and are being treated with aliskiren-containing medications or a group of medicines known as AIIRAs (a medication also used to treat high blood pressure). - are pregnant or intend to become pregnant. Ramipril AN may affect your developing baby if you take it during pregnancy. - are breastfeeding. Ramipril AN may pass into the breast milk and affect your breastfed baby. Do not use Ramipril AN after the expiry date (EXP) printed on the pack. If you take this medicine after the expiry date has passed, it may not work as well. Do not use Ramipril AN if the packaging is torn or shows signs of tampering.

Before you start to take it

Tell your doctor if you have allergies to:

  • any other medicines
  • any other substances, such as foods, preservatives or dyes Tell your doctor if you have or have had any medical conditions, especially the following:
  • kidney problems, or are having dialysis (note that your doctor may give you Ramipril AN because of your kidney problems)
  • liver problems
  • heart problems (note that your doctor may give you Ramipril AN because of your heart problems)
  • low blood pressure, which you may notice as dizziness or lightheadedness
  • low white blood cell counts
  • diabetes (note that your doctor may give you Ramipril AN because of your diabetes)
  • high levels of potassium in your blood
  • Systemic Lupus Erythematosus (SLE), scleroderma or other autoimmune conditions Tell your doctor if you have a family history of swelling of the face, lips, tongue, throat, intestines, hands or feet. You must also tell your doctor if you:
  • are following a very low or very high salt diet
  • are dehydrated, or have had a recent bout of vomiting or diarrhoea
  • are about to have surgery or a general anaesthetic
  • plan to become pregnant or breastfeed

If you have not told your doctor about any of the above, tell them before you start taking Ramipril AN.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food store.

Some medicines and Ramipril AN may interfere with each other. These include:

  • other medicines used to treat high blood pressure, including those containing the active ingredient aliskiren
  • diuretics, also known as fluid or water tablets
  • lithium, a medicine used to treat mood swings and some types of depression
  • potassium supplements or potassium- containing salt substitutes
  • non-steroidal anti-inflammatory drugs (NSAIDs), medicines used to relieve pain, swelling and other symptoms of inflammation
  • insulin and tablets used to treat diabetes
  • heparin
  • general anaesthetics
  • medicines which may affect the blood cells, such as allopurinol, procainamide, corticosteroids, immunosuppressants, or medicines used to treat cancer
  • temsirolimus
  • if you are taking Ramipril AN for high blood pressure, do not take any medicines (including the ones bought without a prescription) for appetite control, asthma, colds, coughs, hayfever or sinus problems unless you have discussed it with your doctor or pharmacist.

These medicines may be affected by Ramipril AN, or may affect how well it works. You may need to use different amounts of your medicine, or you may need to take different medicines. Your doctor or pharmacist will advise you.

Your doctor or pharmacist may have more information on medicines to be careful with or to avoid while taking Ramipril AN.

How to take Ramipril AN

How much to take

Your doctor or pharmacist will tell you how many tablets you will need to take each day. This depends on your condition and whether or not you are taking any other medicines.

Take Ramipril AN only when prescribed by your doctor.

Your doctor will select a dose when they prescribe Ramipril AN for you. Some patients may need a lower starting dose. The usual dose of Ramipril AN is:

  • for high blood pressure, 2.5 mg to 10 mg per day.
  • for heart failure, 5 mg to 10 mg per day.
  • for kidney problems, 1.25 mg to 5 mg per day.
  • for cardiovascular risk, 2.5 mg to 10 mg per day.

Depending on your response, your doctor may adjust the dose.

Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet. If you do not understand the instructions on the box, ask your doctor or pharmacist for help.

How to take it

Ramipril AN should be swallowed whole with plenty of fluid.

When to take it

Take Ramipril AN at about the same time each day. Taking your tablets at the same time each day will have the best effect. It will also help you remember when to take your medicine. It does not matter if you take Ramipril AN before or after food.

How long to take it

Ramipril AN helps control your condition, but does not cure it. Therefore you must take Ramipril AN every day. Continue taking your medicine for as long as your doctor tells you.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose that you missed. If you are not sure what to do or if you have trouble remembering when to take Ramipril AN, ask your doctor or pharmacist.

If you take too much (Overdose)

Immediately telephone your doctor or the Poisons Information Centre (in Australia telephone 13 11 26), or go to Accident and Emergency at the nearest hospital if you think that you or anyone else may have taken too much Ramipril AN. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. If you take too much Ramipril AN, you may feel light-headed, dizzy or you may faint. You may also experience slow heart beat.

While you are taking Ramipril AN

Things you must do

Tell all the doctors, dentists and pharmacists who are treating you that you are taking Ramipril AN. If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking Ramipril AN. Make sure you drink enough water during exercise and hot weather when you are taking Ramipril AN, especially if you sweat a lot. If you do not drink enough water while taking Ramipril AN, you may feel faint, light-headed or sick. This is because your blood pressure is dropping suddenly. If you continue to feel unwell, tell your doctor. If you have excess vomiting or diarrhoea while taking Ramipril AN, tell your doctor. You may lose too much water and salt and your blood pressure may drop too much. If you feel light-headed or dizzy after taking your first dose of Ramipril AN, or when your dose is increased, tell your doctor immediately.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking Ramipril AN. Your blood pressure may drop suddenly. If you become pregnant or intend to become pregnant while taking Ramipril AN, tell your doctor immediately. If you are about to have any blood tests, tell your doctor that you are taking Ramipril AN. Ramipril AN may interfere with the results of some tests. Have your blood pressure checked when your doctor says, to make sure Ramipril AN is working. Go to your doctor regularly for a check-up. Your doctor may occasionally do a blood test to check your potassium levels and see how your kidneys are working.

Things you must not do

Do not give Ramipril AN to anyone else, even if they have the same condition as you. Do not take Ramipril AN to treat any other complaints unless your doctor or pharmacist tells you to. Do not stop taking Ramipril AN, or lower or increase the dosage, without checking with your doctor.

Things to be careful of

If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor. Be careful driving or operating machinery until you know how Ramipril AN affects you. As with other ACE inhibitor medicines, Ramipril AN may cause dizziness, lightheadedness, tiredness or drowsiness in some people. Make sure you know how you react to Ramipril AN before you drive a car, operate machinery, or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs do not drive. If you drink alcohol, dizziness or lightheadedness may be worse.

Things that may help your condition

Some self help measures suggested below may help your condition. Talk to your doctor or pharmacist about these measures and for more information.

  • Alcohol - your doctor may advise you to limit your alcohol intake.
  • Diet - eat a healthy low-fat diet which includes plenty of fresh vegetables, fruit, bread, cereals and fish. Also eat less fat and sugar.
  • Exercise - regular exercise helps to reduce blood pressure and helps get the heart fitter, but it is important not to overdo it. Walking is good exercise, but try to find a route that is reasonably flat. Before starting any exercise, ask your doctor about the best kind of programme for you.
  • Salt - your doctor may advise you to watch the amount of salt in your diet. To reduce your salt intake you should avoid using salt in cooking or at the table.
  • Smoking - your doctor may advise you to stop or at least cut down smoking.