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Lck
a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes. TERM 2
CD
DEFINITION 2 Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. TERM 3
ZAP-
DEFINITION 3 ZAP-70 is an abbreviation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). TERM 4
DAG, IP
DEFINITION 4 Second messengers TERM 5
CD
DEFINITION 5 In immunology, the ------T-Cell Co-Receptor (CD stands for cluster of differentiation) is a protein complex and is composed of four distinct chains.
p56Lck
is essential for initiation of TCR signaling TERM 7
ZAP-
DEFINITION 7 atalyzes phosphorylation of various membrane-associated adaptor molecules TERM 8
DAG
DEFINITION 8 activates the multifunctional protein kinase C, which phosphorylates in various pathways TERM 9
NFAT
DEFINITION 9 Nuclear factor of activated T-cells is a general name applied to a family of transcription factors shown to be important in immune response. TERM 10
NFAT
DEFINITION 10 indirectly activates expression of cytokines which promote thymocyte growth
Fos
is phosphorylated by MAP Kinase and associates with Jun to form AP- TERM 17
AP-
DEFINITION 17 is an essential transcription factor for T cell activation and IL- 2 transcription. TERM 18
Signal 1
DEFINITION 18 is the initial interaction between TCR-CD3 and peptide-MHC. TERM 19
Signal 2
DEFINITION 19 is is provided by thymocyte CD28 and CD152 interaction with B7 proteins on the antigen-presenting cell.
