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A comprehensive overview of the process of protein targeting and translocation into the endoplasmic reticulum (er). It covers the key features of the er, including its structure, functions, and the mechanisms by which proteins are directed to and translocated across the er membrane. The role of signal sequences, the signal recognition particle (srp), and the translocon complex in the cotranslational translocation of proteins into the er. It also explores the processes of n-linked glycosylation, lipid anchoring, and protein folding within the er lumen. The document delves into the quality control mechanisms that ensure proper protein folding, including the involvement of chaperone proteins and the unfolded protein response. Overall, this document offers a detailed understanding of the complex and dynamic processes involved in protein targeting and trafficking within the er, which is a crucial component of the endomembrane system and cellular secretory pathways.
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Topologically equivalent compartments in the secretory and endocytic pathways
McGraw Hill Higher Education
The two types of ER membranes can be separated by gradient centrifugation
Microsomes EM
Membrane bound and free polyribosomes
A signal sequence directs proteins to the ER
How is the ER targeting signal recognized?