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A comprehensive overview of key concepts in pharmacy foundations, focusing on common enzyme inhibitors, injectable medications, and other essential topics. It includes a list of drugs that require refrigeration, vesicants, drugs with leaching/adsorption/absorption issues, and drugs that can only be placed in saline or dextrose. The document also covers therapeutic ranges for various medications, guidelines for common conditions, and important resources for pharmacy professionals. A valuable resource for pharmacy students preparing for the naplex exam.
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Common Enzyme Inhibitors G: P: A: C: M: A: N: - CORRECT ANSWER Grapefruit Juice Protease Inhibitors Azole Antifungals Cyclosporine, Cobicistat, Cimetidine Macrolide Antibiotics Amiodarone, Dronedarone Non-DHP CCB's (Diltiazem, Verapamil) Common Enzyme Inducers P: S: P: O: R: C: S: - CORRECT ANSWER Phenytoin Smoking Phenobarbital Oxcarbazepine Rifampin Carbamazepine
St. John's Wort Which of the following self-administered, injectable medications do NOT require refrigeration? A. Lovenox B. golimumab C. Tymlos D. Enbrel - CORRECT ANSWER Correct Answer: A. Lovenox Lovenox (Enoxaparin) is the only drug present that does not require refrigeration. Golimumab (Simponi), Abaloparatide (Tymlos), Etanercept (Enbrel) all require refrigeration. Injectable Medications that DO NOT Require Refrigeration (1) (2) (3) (4) (5) - CORRECT ANSWER Enoxaparin (Lovenox) Fondaparinux (Arixtra) Methotrexate (Otrexup, others) Sumatriptan (Imitrex, Zembrace, SymTouch) Phenytoin (Dilantin) Ear Drop Counseling
Amophotericin B Lipids - 1.2 Micron Isavuconazonium Phenytoin Amiodarone Taxanes Mannitol > or equal to 20% Parenteral Nutrition - 1.2 Micron Do Not Refrigerate Drugs Dear Sweet Pharmacist Freezing Makes Me Edgy - CORRECT ANSWER Dexmedetomidine Sulfamethoxazole/Trimethoprim Phenytoin Furosemide Metronidazole Moxifloxacin Enoxaparin Protect from Light During Administration Protect Every Necessary Med from Daylight - CORRECT ANSWER Phytonadione (Vitamin K) Epoprostenol Nitroprusside Micafungin Doxycycline The parasympathetic nervous system is the system that focuses on "resting and digesting". Which of the following are effects of stimulating this system? [SATA] A. Increased HR B. Increased Urination C. Increased Lacrimation D. Decreased Digestion E. Pupil Dilation - CORRECT ANSWER B. Increased Urination C. Increased Lacrimation
The parasympathetic nervous system carries several "SLUDD" effects with its activation. These include increased Salivation, Lacrimation, Urination, Diarrhea, and Digestion. The pupils in your eyes will also constrict. The sympathetic nervous system is responsible for your "fight or flight" responses. Stimulation of this system can include decreasing things like digestion (peristalsis) & urination and increasing your HR, BP, and bronchodilation. The pupils in your eyes will also dilate to more easily capture a view of your surroundings. More info can be found on page 44 in your NAPLEX book (2024). ________________ Book
Red Book The Harriet Lane Handbook American Academy of Pediatrics ASHP Nelson Textbook What are the 2 resources that can be used for Pharmacology? - CORRECT ANSWER Goodman and Gilman's Katzung's Basic and Clinical Pharmacology What are the 4 resources that can be used for Pregnancy and Lactation? - CORRECT ANSWER Brigg's CDC Hale's LactMed (Micromedex) What are the 2 resources that can be used for Regulatory and Business Developments? - CORRECT ANSWER Pink Sheet Center for Drug Evaluation and Research (CDER) What are the 5 resources that can be used for Therapeutics and Disease Management? - CORRECT ANSWER DiPiro's Handbook of Nonprescription Drugs Koda-Kimble's The Merck Manual UpToDate What is the resource that can be used for Veterinary? - CORRECT ANSWER Plumb's Usual Therapeutic Ranges: Carbamazepine - CORRECT ANSWER 4 - 12 mcg/mL Usual Therapeutic Ranges: Digoxin AF? HF? - CORRECT ANSWER 0.8 - 2 ng/mL (AF) 0.5 - 0.9 ng/mL (HF)
Usual Therapeutic Ranges: Gentamicin Peak? Trough? - CORRECT ANSWER 5 - 10 mcg/mL < 2 mcg/mL Usual Therapeutic Ranges: Lithium This drug is drawn as a (peak / trough)? - CORRECT ANSWER 0.6 - 1.2 mEq/L trough Usual Therapeutic Ranges: Phenytoin / Fosphenytoin + Free Phenytoin Phenytoin / Fosphenytoin: May need to calculate a corrected level if __________________ is low. Free: - CORRECT ANSWER 10 - 20 mcg/mL albumin 1 - 2.5 mcg/mL Usual Therapeutic Ranges: Procainamide - CORRECT ANSWER 4 - 10 mcg/mL Usual Therapeutic Ranges: Theophylline Taken as a (peak / trough) - CORRECT ANSWER 5 - 15 mcg/mL peak Usual Therapeutic Ranges: Tobramycin Peak? Trough? - CORRECT ANSWER 5 - 10 mcg/mL < 2 mcg/mL Usual Therapeutic Ranges: Valproic Acid (VPA) - CORRECT ANSWER 50 - 100 mcg/mL
_____ kcal/mL - CORRECT ANSWER 3.
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2 3 What is the calculation for Corrected Calcium? When is this calculated? - CORRECT ANSWER Corrected Ca2+ = Serum Calcium + [(4.0 - Albumin) x (0.8)] When albumin is not within therapeutic range of 3.5 - 5.0. What is the formula to calculate a patient's ANC? - CORRECT ANSWER ANC = WBC x [(segs % + % bands) / 100] Other Drugs with Leaching/Adsorption/Absorption Issues
Excipients Safety Data Sheets (SDS) Merck Index Remington Trissel's 795 797 800 NF What are the 4 key resources for looking up Drug Interactions?
Updates published in the ________________
MMWR (Morbidity & Mortality Weekly Report) Pink Immunization Action Coalition APhA FDA What are the 2 key resources for looking up Infectious Diseases?
[] Lexicomp [] Micromedex [] mobilePDR - CORRECT ANSWER Yes Yes Yes Yes Yes Yes Yes No IV Drug Compatibility (Yes/No) [] AHFS / AHFS CDI [] Clinical Pharmacology [] Drugs.com [] Epocrates / Epocrates + [] Facts & Comparisons eAnswers [] Lexicomp [] Micromedex [] mobilePDR - CORRECT ANSWER Yes Yes (via Trissel's) No No Yes (via Trissel's) Yes (via Trissel's) Yes (via Trissel's) No Drugs / Pill Identification (Yes/No) [] AHFS / AHFS CDI [] Clinical Pharmacology [] Drugs.com [] Epocrates / Epocrates + [] Facts & Comparisons eAnswers [] Lexicomp [] Micromedex [] mobilePDR - CORRECT ANSWER No
Yes Yes Yes Yes Yes (Lexi-Drug ID) Yes (IDENTIDEX) Yes Natural Products (Yes/No) [] AHFS / AHFS CDI [] Clinical Pharmacology [] Drugs.com [] Epocrates / Epocrates + [] Facts & Comparisons eAnswers [] Lexicomp [] Micromedex [] mobilePDR - CORRECT ANSWER No Yes Yes Yes Yes Yes (Lexi-Natural Products) Yes (AltMedDex) No Drug Class Comparisons (Yes/No) [] AHFS / AHFS CDI [] Clinical Pharmacology [] Drugs.com [] Epocrates / Epocrates + [] Facts & Comparisons eAnswers [] Lexicomp [] Micromedex [] mobilePDR - CORRECT ANSWER No Yes Yes Yes
