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Pharmacotherapeutics For Advanced Practice Nurse Prescribers: Chapter 6. An Introductio, Exams of Nursing

Rhodes State CollegeNursing

Pharmacotherapeutics For Advanced Practice Nurse Prescribers: Chapter 6. An Introduction To Pharmacogenomics Exam Questions With Verified Answers

Typology: Exams

2024/2025

Available from 05/29/2025

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Pharmacotherapeutics For Advanced
Practice Nurse Prescribers: Chapter 6.
An Introduction To Pharmacogenomics
Exam Questions With Verified Answers
UPGRADED A+
Genetic polymorphisms account for differences in metabolism, including:
1. Poor metabolizers, who lack a working enzyme
2. Intermediate metabolizers, who have one working, wild-type allele and one mutant allele
3. Extensive metabolizers, with two normally functioning alleles
4. All of the above
ANS: 4
Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
1. A need to monitor drugs metabolized by 2D6 for toxicity
2. Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake
inhibitors
3. Decreased conversion of codeine to morphine by CYP2D6
4. The need for lowered dosages of drugs, such as beta blockers
ANS: 2
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Partial preview of the text

Download Pharmacotherapeutics For Advanced Practice Nurse Prescribers: Chapter 6. An Introductio and more Exams Nursing in PDF only on Docsity!

Pharmacotherapeutics For Advanced

Practice Nurse Prescribers: Chapter 6.

An Introduction To Pharmacogenomics

Exam Questions With Verified Answers

UPGRADED A+

Genetic polymorphisms account for differences in metabolism, including:

  1. Poor metabolizers, who lack a working enzyme
  2. Intermediate metabolizers, who have one working, wild-type allele and one mutant allele
  3. Extensive metabolizers, with two normally functioning alleles
  4. All of the above

ANS: 4

Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:

  1. A need to monitor drugs metabolized by 2D6 for toxicity
  2. Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors
  3. Decreased conversion of codeine to morphine by CYP2D
  4. The need for lowered dosages of drugs, such as beta blockers

ANS: 2

Rifampin is a nonspecific CYP450 inducer that may:

  1. Lead to toxic levels of rifampin and so must be monitored closely
  2. Cause toxic levels of drugs, such as oral contraceptives, when coadministered
  3. Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
  4. Cause nonspecific changes in drug metabolism

ANS: 3

Inhibition of P-glycoprotein by a drug such as quinidine may lead to:

  1. Decreased therapeutic levels of quinidine
  2. Increased therapeutic levels of quinidine
  3. Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination
  4. Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination

ANS: 4

Warfarin resistance may be seen in patients with a VKORC1 mutation, leading to:

  1. Toxic levels of warfarin building up
  2. Decreased response to warfarin
  3. Increased risk for significant drug interactions with warfarin
  1. Increased risk for Stevens-Johnson syndrome in Asian patients with the HLA-B*1502 allele
  2. Patients who have the HLA-B*1502 allele being more likely to have a resistance to carbamazepine

ANS: 3

A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to:

  1. Decreased effectiveness of irinotecan in the treatment of cancer
  2. Increased adverse drug reactions, such as neutropenia
  3. Delayed metabolism of the prodrug irinotecan into the active metabolite SN- 38
  4. Increased concerns for irinotecan being carcinogenic

ANS: 2

Patients who have a poor metabolism phenotype will have:

  1. Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug
  2. Accumulation of inactive metabolites of drugs
  3. A need for increased dosages of medications
  4. Increased elimination of an active drug

ANS: 1

Ultra-rapid metabolizers of drugs may have:

  1. To have dosages of drugs adjusted downward to prevent drug accumulation
  2. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure
  3. Increased elimination of active, nonmetabolized drug
  4. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug

ANS: 2

A provider may consider testing for CYP2D6 variants prior to starting tamoxifen for breast cancer to:

  1. Ensure the patient will not have increased adverse drug reactions to the tamoxifen
  2. Identify potential drug-drug interactions that may occur with tamoxifen
  3. Reduce the likelihood of therapeutic failure with tamoxifen treatment
  4. Identify poor metabolizers of tamoxifen

ANS: 3