Pharmacology Lecture Notes
What the drug does to the body; -
Pharmacodynamics
change the physical properties of a part of the body; chemically combine with other
substances; binding to a receptor site; -
Three general ways drugs work;
A group of macromolecules through which drugs act; -
Drug Receptor
A molecule that binds to another molecule [i.e. hormones, neurotransmitters, many
drugs] -
Ligand
What are the four primary receptor families? -
Cell membrane- embedded enzyme; Ligand gated channels; G Protein-coupled
receport systems; Transcription Factors
__________ is proportional to the number of receptors occupied by drugs (usually up to
a point). -
Intensity of response
___________ occurs when a drug produces the largest response it can. (giving more of
the drug does not produce more result.) -
Maximal Response
This type of enzyme spans the cell membrane with the binding site outside and the
catalytic site inside. [i.e. insulin] -
Cell Membrane Embedded Enzyme
One method to regulate the flow of ions out of cells. Crucial for the transmission of the
nerve signal across synaptic cleft. [i.e. receptor for acetylcholine] -
Ligand Gated Ion Channels
