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Pharmacokinetics (Formulas) | PHAR - Pharmacology, Quizzes of Pharmacology

Class: PHAR - Pharmacology; Subject: Pharmacology; University: Samuel Merritt College; Term: Forever 1989;

Typology: Quizzes

2012/2013

Uploaded on 08/02/2013

cantwell77515
cantwell77515 🇺🇸

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TERM 1
Volume of Distribution
DEFINITION 1
Vd = total amount of drug in the body = L/70 kg Cp
TERM 2
Clearance
DEFINITION 2
CL = elimination rate =L/h/70 kg Cp
TERM 3
Half-Life
DEFINITION 3
t1/2 = 0.7 (Vd) = h CL Note: 0.7 is a constant
TERM 4
Bioavailability
DEFINITION 4
F = 100% by iv by definition = %
TERM 5
Loading Dose
DEFINITION 5
Loading dose= Vd (target Cp) = mg
pf2

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TERM 1

Volume of Distribution

DEFINITION 1 Vd = total amount of drug in the body = L/70 kg Cp TERM 2

Clearance

DEFINITION 2 CL = elimination rate =L/h/70 kg Cp TERM 3

Half-Life

DEFINITION 3 t1/2 = 0.7 (Vd) = h CL Note: 0.7 is a constant TERM 4

Bioavailability

DEFINITION 4 F = 100% by iv by definition = % TERM 5

Loading Dose

DEFINITION 5 Loading dose= Vd (target Cp) = mg

TERM 6

Creatinine Clearance (CC)

DEFINITION 6 CC = (140- age) (2.12) (weight kg) (K) = mL/min (plasma creatinine) (body surface area m2) K = 1.0 for male; 0.85 for female