Pharmaceutics Multiple Choice Questions | Exercises Biopharmaceutics and Pharmacokinetics

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Page 1

S.No Question

correct option number

Option 1

1 1 13-16%

2 4 essential amino acid

3 Nanocapsules have size less than 1 1-20um

4 3 cationic emulsifier

5 Polyethylene glycol is also called as 3 macrogols

6 What is bloom strength of hard gelatin shell. 2 150 g

7 4 bone

8 The largest size of capsule is 4 5

9 3 1000

10 Hazing of the film is also called as 4 dull film

11 Spanules are 3 soft gelatin capsule

12 Nanocapsules have size less than 1 1-20um

13 the first digit in the propellent number represent 2 no, of fluorin atom

14 The Exveka KEA is 4

15 2 additive

16 Isoelectric point of type A gelatin is______ 1 4.8-5

17 7-9 is isoelectric point of 2 gelatin

18 Dip coating is use for 2

19 Relative humidity of softgel is 1 0.35

20 Tag open cap apparatus for evalution of 3

21 Aerosole store at temperature above 1

22 Dip tubes in aerosols are made up of______ 1

23 2 wool fat

24 3 cationic emulsifier

25 Hydrous wool fat is a mixture of 1

26 Polyethylene glycol is also called as 3 macrogols

27 Which of the following is viscous liquid 2 macrogel 1500

28 Simple ointment contains base 1 oleaginous

29 Liquid paraffin IP has viscosity greater than 4 65 centistokes

30 Tragacanth has HLB value 4 9.8

31 2 cloud point

32 Polysorbate 20 inactivates 3 parabens

33 Liquid paraffin shows type of flow 3 plastic

Hard gelatin capsule contains ______% of

moisture

Protien constituent of gelatin is type of amino

acid

Official anhydrous water miscible ointment bases

i.e emulsifying ointment contains

Source of rae material derived from cown can be

gelatin

Obaka automatic capsule filler capable of filling

up to_____capsule/hour

dedusting & polishing machine of

tablet

____element in regularly given to modify the

solubility of gelatin capsule

repeated coating and dying

flame projection

40 c

polyethylene & polypropylene

Which one of the following comes under the

category of oleaginous bases

Official anhydrous water miscible ointment bases

i.e emulsifying ointment contains

70%w/w wool fat&30%W/w

purified water

Sudden increase in solubility of micells forming

surfactant above definite tempreture is known as

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S.No Question correct option numberOption 1 1 1 13-16% 2 4 essential amino acid 3 Nanocapsules have size less than 1 1-20um 4 3 cationic emulsifier 5 Polyethylene glycol is also called as 3 macrogols 6 What is bloom strength of hard gelatin shell. 2 150 g 7 4 bone 8 The largest size of capsule is 4 5 9 3 1000 10 Hazing of the film is also called as 4 dull film 11 Spanules are 3 soft gelatin capsule 12 Nanocapsules have size less than 1 1-20um 13 the first digit in the propellent number represent 2 no, of fluorin atom 14 The Exveka KEA is 4 15 2 additive 16 Isoelectric point of type A gelatin is______ 1 4.8- 17 7-9 is isoelectric point of 2 gelatin 18 Dip coating is use for 2 19 Relative humidity of softgel is 1 0. 20 Tag open cap apparatus for evalution of 3 21 Aerosole store at temperature above 1 22 Dip tubes in aerosols are made up of______ 1 23 2 wool fat 24 3 cationic emulsifier 25 Hydrous wool fat is a mixture of 1 26 Polyethylene glycol is also called as 3 macrogols 27 Which of the following is viscous liquid 2 macrogel 1500 28 Simple ointment contains base 1 oleaginous 29 Liquid paraffin IP has viscosity greater than 4 65 centistokes 30 Tragacanth has HLB value 4 9. 31 2 cloud point 32 Polysorbate 20 inactivates 3 parabens 33 Liquid paraffin shows type of flow 3 plastic Hard gelatin capsule contains ______% of moisture Protien constituent of gelatin is type of amino acid Official anhydrous water miscible ointment bases i.e emulsifying ointment contains Source of rae material derived from cown can be gelatin Obaka automatic capsule filler capable of filling up to_____capsule/hour dedusting & polishing machine of tablet ____element in regularly given to modify the solubility of gelatin capsule repeated coating and dying flame projection 40 c polyethylene & polypropylene Which one of the following comes under the category of oleaginous bases Official anhydrous water miscible ointment bases i.e emulsifying ointment contains 70%w/w wool fat&30%W/w purified water Sudden increase in solubility of micells forming surfactant above definite tempreture is known as

34 Protective property of colloid is expressed by 1 gold no. 35 Unna’s paste is mixture of 4 36 Conductivity test is performed for 2 37 3 0. 38 4 parabens 39 1 3500- 40 4 0. 41 1 42 The suppositories should be stored at 2 25+20c & 40c 43 4 incipient/thaw point 44 The gamma form of cocoa butter melts at 4 190 c 45 1 86-95F 46 Formula for HLB value is 4 47 Polyethylene glycol bases are incompatible with 4 sodium salt 48 Maillard reaction asociated with 1 diluents 49 1 acrosil 50 Its shows negative heat of solution are 1 manitol 51 Trade name of microcrystalline cellulose is 1 avicel 52 Lubricant used in tablet formulation for 4 53 3 croscarmelose 54 Thinner the tablet indicates that 1 55 1 CAP 56 Which is the following modified starch 1 57 1 Monsanto 58 Unit of hardness 4 Kg/sq.in 59 According to USP type I dissolution apparatus is 1 basket 60 1 roache fribilator 61 1 0.5-1% 62 1 ferric oxide,saccharine,sodium & gelatin w/o emulsion system Bottle method preparation of emulsion used the proportion of fixed oil:water:acacia ______ is the bactericidal recommended for ophthalmic used The output of a typical rotary machine ranges from --to—suppositories an hour The displacement factor of boric acid is ____to the cocoa butter Cocoa butter suppositories in storage sometime form a white powder diposite on surface Melting point of suppositories base is determined by The melting point of cocoa butter lies between__to__ 20-[1-acid value/sap value] Which is the foolowing ingredient use as antiadherent to lubricate all ingredient in the tablet Which of the superdisintegrants are used in tablet formulation hard tablet Which of the following material used in enteric coated tablet staRX- Which are the following apparatus used for tablet hardnes testing Which are the following apparatus used for friability testing According to USP standard limit for friability test is According to IP disintegration time for dispersible tablet is within 3 min in water at 250c + 10c

82 2 a) Kinetic strength 83 3 84 1 85 The loading dose of a drug is usually based on 4 86 The characteristics of a good NDDS carrier are: 4 87 3 88 4 (a) Dibasic calcium phosphate 89 1 (a) Mechanical strength 90 4 (a) Animal Protein mainly gelatin 91 Vegetable capsules are composed of 3 (a) Hypromellose 92 4 93 4 94 4 95 1 96 3 97 3 98 1 The effect of partition coefficient on the controlled release of drugs from a matrix type drug delivery device was reported as a) The mechanism of drug release were dependent upon the variation in the partition coefficient Fillers are often incorporated into polymer to enhance Both the in-vitro and in-vivo rates of drug release are observed to be dependent on a) Upon the surface area of drug delivery device One of the materials listed below is most commonly used in film coating of Tablets, Identify. (a) Hydroxypropyl Methyl Cellulose (a) Total body clearance of the drug (a) Optimum drug quantity can be loaded into it. Tablet is one of the following forms that an oral drug can take such as (a)^ Syrups & suspension A wide variety of binders used in tablet dosage form some common one including The hardness of tablets is the principle measurement of Capsules are made from aqueous solutions of gelling agents like The applicability of Noyes-Whitney equation is to describe (a) First order kinetics The ability of human eye using illuminated area to detect a particle is limited to (a) 0.4 micron Which filler can NOT be used for the preparation of tablets for amine containing basic drugs to avoid discoloration of the tablets? (a) Dicalcium phosphate In which of the following techniques the sample is kept below triple point? (a) Lyophilization Drugs in suspensions and semi-solid formulations always degrade by (a) First order kinetics Modified release drug delivery systems may be divided conveniently in to following categories (a) Delayed release & Sustained release According to USP, the speed regulating device of the dissolution apparatus should be capable of maintaining the speed within limits of what % of the selected speed? (a) 1%

Option 2 Option 3 Option 4 13.5-16% 12-15% non essential amino acid both B&C 1-50um 1-30um nonionic emulsifier none of above carbowaxes both A&B cetogols 220-280 g 190 g hide skin both A&B 8 0 0 200 165000 200- bloom bothA&C hard gelatin capsule bothB&C 1-50um 1-30um no.of carbon atom none of above dedusting of tablet formaline water formaline and water 5-5.8 7_9 4_ type B both B & C acid insoluble coating none of above 0.2 0.15 20-25% identification of propellent 49 c 37 c polyarcryne none of above liq.paraffin hydrous wool fat bees wax nonionic emulsifier none of above carbowaxes both A&B cetogols macrogel 400 macrogel 1540 macrogel 6000 water soluble water immiscible none of above 60 centistokes all of the above 9.7 12.01 13. kraft point CMC none of above mercurials thiazole Newtonian flow pseudoplastic thixotropic

glycine & proline 20-50um anionic emulsifier 170 g arrange peel effect hard gelatin capsule filled with coated granules or bed 20-50um no, of hydrogen atom polishing machine of capsule dedusting and polishing machine of capsule type C bothA & C flash point aerosole value discharge rate 25 c polyarcryne & polyethylene anionic emulsifier 60%w/w wool fat&40%W/w purified water 30%w/w wool fat&70%W/w purified water 80%w/w wool fat&20%W/ w purified water 30 centistokes benzalconium chloride

lamination shipping both A&B colour variation bothA&B crack of tablet surface stick of tablet solubility analysis all of above amorphous polymorphs entiotrops crystalline none of above unstable form none of above they absorb moisture none of the above TGA all of the above none of the above All of the above b) Cylinder c) Sheet d) All of the above c) Solubility d) All of the above d) All of the above d) All of the above c) Both a & b d) None of the above from 10-30 parts of solvent required for 1 part of solute from 1000 to 10000 parts of solvent required for 1 part of solute from 100 to 1000 parts of solvent required for 1 part of solute orange peel effect adhering tablet to die wall stability analysis bothA&B amorphous form they losses the water karl-fischer titration MCC for resistant to acidic pH for resistant to acidic pH Activation-modulated drug delivery system site-targeting drug delivery system b) Diffusional path thickness b) Increase in concentration c) Increase in no of small molecules b) Arrhenius relationship c) Both a & b d) None of the above b) Bio-pharmaceutics and pharmacokinetics of the therapeutic agent in the body after its delivery from a drug delivery systems c) Pharmacodynamics of the therapeutic agent at the site of drug actions b) Increase in the concentration of drugs

c) Both a & b d) None of the above b) Mechanical strength c) None of the above d) Both a & b c) Both a & b d) None of the above (b) Acacia (c) Simple Syrup (d) Bees Wax (d) All of the above (b) Corn (maize) starch (b) Kinetic energy (c ) Both a & b (b) Plant polysaccharides (d) All the above (c) Both a & b (d) None of the above (b) Zero order kinetics (d) Dissolution rate (d) 10 micron (d) Lactose (b) Spray drying (d) Centrifugation (b) Second order kinetics (d) Non-linear kinetics (c) Both a & b (d) None of the above b) The rate profile of drug release were dependent upon the variation in the partition coefficient b) Different lengths of treatment (b) Percentage of drug bound to plasma proteins (c) Fraction of drug excreted unchanged in urine (d) Apparent volume of distribution and desired drug concentration in plasma (b) The release of the drug inside the body is pulsatile in nature. (c) It should not be immunogenic in nature. (b) Elixirs & Emulsion (c) Both a & b (d) None of the above (c ) Povidone polyvinylpyrrolidone and modified cellulose (d) All of the above (a) None of the above (c ) Modified forms of starch and cellulose (b) A polymer formulated from cellulose (c) Mixed order kinetics (b) 25 micron (c) 50 micron (b) Microcrystalline cellulose (c) Starch (c) Spray congealing (c) Zero order kinetics (b) Site specific targeting & Receptor targeting (b) 2% (c) 4% (d) 5%

Pharmaceutics Multiple Choice Questions, Exercises of Biopharmaceutics and Pharmacokinetics

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