Docsity
Docsity

Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity


Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan


Guidelines and tips
Guidelines and tips

Trophoblastic Disease: Types, Histology, and Follow-up, Exercises of Cancer Cytogenetics

An overview of trophoblastic disease, including different types such as molar and non-molar gestations, histology of complete and partial moles, and follow-up procedures for patients. It covers key features like villi, fetal development, villous hydrops, trophoblast hyperplasia, and malignant potential.

Typology: Exercises

2011/2012

Uploaded on 08/01/2012

super-malik
super-malik 🇮🇳

4.6

(14)

195 documents

1 / 4

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
I
N SUMMARY HST 071
T
ROPHOBLASTIC DISEASE
T
ROPHOBLASTIC NEOPLASIA
T
ypes of trophoblast neoplas ia
M
olar (always gestational)
o v
illi
N
on
-m
olar (can be non
-g
estational)
o N
o villi
M
olar gestations
o E
rrors in fertilization o
r
meiosis
o A
bnormal paternal contribution to the zygote
T
wo categories:
o C
omplete hydatidiform mole
o P
artial hydatidiform mole
P
artial Hydatidiform Mole
E
xcess tissue:
o O
ccasionally large villi are grossly identifiable but should be < 1cm in
g
reatest dimensi
o
n
F
etal development is possible with characteristic anomalies:
o I
UGR
o 3-4
syndactyly
-
hands
o 2-3
syndactyly
-
feet
o R
enal, cardiac, neural structural anomalies
H
istology:
o T
wo populations villi
-
l
a
rge + cisterns, small
o I
rregular outlines of villi
o V
illous syn
c
ytiotrophoblastic inclusions
o E
xcess and atypical villous synctyiotrophoblast
o
molar” implantation site
o E
mbryonic/fetal development
Ch
aracterized by focal villous hydrops
Fo
cal trophoblastic hyperppasia
Tw
o populations of villi
l
arge and hydropic
b
ackgro
u
nd of small, sclerotic and normal
-s
ized villi
s
calloped villous outlines
t
angential sectioning of the villi results in stromal trophoblastic
i
nclusions
v
illous surfaces may have many tiny projections of syncytiotrophoblast
f
orming notches
F
ocal trophoblas
t
hyperplasia
M
ounds of syncytiotrophoblast
N
uclear atypia infrequent
V
illi vessels contain nucleated R BS and often fetal tissue found
T
riploid
E
xtra haploid DN A is paternal
docsity.com
pf3
pf4

Partial preview of the text

Download Trophoblastic Disease: Types, Histology, and Follow-up and more Exercises Cancer Cytogenetics in PDF only on Docsity!

IN SUMMARY

HST 07 1

TROPHOBLASTIC DISEASE

TROPHOBLASTIC NEOPLASIA

Types of trophoblast neoplasia

  • Molar (always gestational) o villi
  • Non-molar (can be non-gestational) o No villi
  • Molar gestations o Errors in fertilization or meiosis o Abnormal paternal contribution to the zygote
  • Two categories: o Complete hydatidiform mole o Partial hydatidiform mole Partial Hydatidiform Mole
  • Excess tissue: o Occasionally large villi are grossly identifiable but should be < 1cm in greatest dimension
  • Fetal development is possible with characteristic anomalies: o IUGR o 3 - 4 syndactyly - hands o 2 - 3 syndactyly - feet o Renal, cardiac, neural structural anomalies
  • Histology: o Two populations villi - large + cisterns, small o Irregular outlines of villi o Villous syncytiotrophoblastic inclusions o Excess and atypical villous synctyiotrophoblast o “molar” implantation site o Embryonic/fetal development
  • Characterized by focal villous hydrops
  • Focal trophoblastic hyperppasia
  • Two populations of villi
  • large and hydropic
  • background of small, sclerotic and normal-sized villi
  • scalloped villous outlines
  • tangential sectioning of the villi results in stromal trophoblastic inclusions
  • villous surfaces may have many tiny projections of syncytiotrophoblast forming notches
  • Focal trophoblast hyperplasia
  • Mounds of syncytiotrophoblast
  • Nuclear atypia infrequent
  • Villi vessels contain nucleated RBS and often fetal tissue found
  • Triploid
  • Extra haploid DNA is paternal

TROPHOBLASTIC DISEASE

Complete hydatidiform mole

• Villi grossly identifiable, often >1cm in greatest dimension

• No fetal development

• Excess tissue

• Villous hydrops

• Trophoblast hyperplasia

• Cistern formation

• Blood vessels lacking

• Mounds of mitotic cytotrophoblast

• Lacy proliferation of syncitiotrophoblast

• Extravillous trophoblast

• Cytologic atypia

• Diploid

• Nuclear DNA androgenically derived

Molar gestations

• Complete moles - choriocarcinoma, recurrence

• Partial moles - rarely persist

Imprinting

• Molar gestations are evidence of difference between maternal and patnernal

DNA

• Molar pregnancies are due to a overabundance of paternal DNA

• Paternal DNA preferentially makes extraembryonic

• Maternal DNA preferentially makes embryonic tissues

Choriocarcinoma

  • Malignancy of all trophoplast lineages
  • Gestational or non-gestational
  • Presents with bleeding, toxemia
  • Widely metastatic
  • Gestational is chemosensitive
  • Followed with bHCG and imaging
  • Histology of choriocarcinoma
  • Biphasic trophoblast
  • Hemorrhage and necrosis Choriocarcinoma in situ

• Can present as mass-like lesions in the placenta

• Can cross the placenta to metastasize to fetus

• Silent at placental presentation or widely metastatic

TROPHOBLASTIC DISEASE