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Pediatrie Gastric Emptying: Value of Right Lateral and Upright ..., Lecture notes of Radiology

Inthe supine position 19 of 48 patients showed significant emptying (defined as >40% emptying). This increased to 41 of 48 normal studies considering the right ...

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CONCLUSION
SPECT bone scanning of the knee is superior to planar
imaging in detecting ACL injury and is a sensitive examination
in a population of patients predominantly with chronic ACL
tears. Sensitivity may be dependent on the chronicity of
symptoms although acute tears and both partial and complete
tears can be identified.
Focal activity at either end of the ACL attachments may be
seen, but the more common appearance is of a single, focal
abnormality in the medial aspect of the posterior, lateral femoral
condyle. This pattern has not been previously reported in
patients with acute tears and may therefore occur more fre
quently in those with chronic symptoms.
SPECT imaging of the knee may be a valuable examination
in suspected ACL injury particularly if MRI is not available, if
MRI is equivocal or if the clinical signs do not support a
diagnosis of ACL tears detected by MRI. In addition, knee
SPECT is able to localize other areas of injury within the knee
associated with ACL tears.
REFERENCES
1. Holder LE, Machin JL, Asdourian PL, et al. Planar and high-resolution SPECT bone
imaging in the diagnosis of facet syndrome. J NucÃ-Med l995;36:37-44.
2. Ryan PJ, Evans P, Gibson T. Fogelman I. Chronic low back pain: comparison of bone
SPECT, radiography and CT. Radiology 1992;182:849-854.
3. Murray IPC. Dixon J. Kohan L. SPECT for acute knee pain. Clin NucÃ- Med
1990:15:828-840.
4. Collier BD, Johnson RP, Carrera GF, et al. Chronic knee pain assessed by SPECT:
comparison with other modalities. Radiology 1985:157:795-802.
5. Fajman WA, Diehl M, Dunaway E, et al. SPECT for acute knee pain [Abstract]. J NucÃ-
Med 1985:26:77.
6. Chissell HR. Allum RL, Keightley A. MRI of the knee: its cost-effective use in a
district general hospital. Ann R Coll Surg Engl. 1994;76(l):26-29.
7. Reicher MA, Hartzman S. Bassett LW. et al. MRI imaging of the knee. Traumatic
disorders. Radiology 1987:162:547-551.
8. Le Vot J, Solacroup JC, Leonetti. et al. Correlations between clinical examination.
MRI and arthroscopy in acute traumatic knees. J Radio! 1993:74:483-492.
9. Mink JH. Levy T, Crues JV. Tears of the anterior cruciate ligament and menisci of the
knee: MR imaging evaluation. Radiology 1988:167:769-774.
10. Herman LJ, Beltran J. Pitfalls in MR imaging of the knee. Radiology 1988:167:775-
781.
11. Selesnick FH, Noble HB, Bachman DC, Steinberg FL. Internal derangement of the
knee: diagnosis by arthrography. arthroscopy and arthrotomy. Clin Orihop 1985:198:
26-30.
Pediatrie Gastric Emptying: Value of Right Lateral
and Upright Positioning
Javier Villanueva-Meyer, Leonard E. Swischuk, Fernando Cesani, Seham A. Ali and Elma Briscoe
Sections of Nuclear Medicine and Pediatrie Radiology, Department of Radiology, University of Texas Medical Branch,
Galveston, Texas
Gastroesophageal reflux and gastric emptying are usually assessed
simultaneously with a 1-hr procedure. After ingestion of radiolabeled
formula sequential images are gathered when the infant is in the
supine position. This position is adequate for gastroesophageal
reflux assessment, but delays gastric emptying. Methods: We
studied 48 children, 1 wk to 2 yr of age, who presented with vomiting
or failure to thrive. They received 99mTc-sulphur colloid in formula.
After completing 1 hr supine imaging we obtained additional ab
dominal views after changing the position of the infant to right lateral
for 30 min, and upright for another 30 min. Results: The percent of
gastric emptying at 60 min in the supine position was 35% ±19%.
At 90 min, in the right lateral decubitus, the percent gastric emptying
was 60% ±25%. At 120 min, after an upright period, the gastric
emptying was 73% ±20%. In the supine position 19 of 48 patients
showed significant emptying (defined as >40% emptying). This
increased to 41 of 48 normal studies considering the right lateral
position and to 45 of 48 normal studies considering the infant
upright position. Conclusion: Many patients with delayed gastric
emptying show significant emptying just by changing position. We
routinely complement gastric emptying studies with delayed views
in the right lateral and upright position.
Key Words: delayed gastric emptying; pediatrie gastric emptying;
gastroesophageal reflux; technetium-99m-sulphur colloid
J NucÃ-Med 1996; 37:1356-1358
A concern in infants with recurrent pulmonary infections,
failure to thrive and vomiting is the presence of gastroesopha
geal reflux or delayed gastric emptying. Gastroesophageal
reflux is routinely assessed with radionuclide scintigraphy or
Received May 22, 1995; revision accepted Sept. 7, 1995.
For correspondence or reprints contact: Javier Villanueva-Meyer, MD, Section of
Nuclear Medicine, UTMB, Galveston, TX 77555-0793.
pH probing (1,2). The pH probe is the most sensitive method
but the radionuclide method, although less sensitive, is thought
to be more physiologic and is widely used (3). The association
of gastroesophageal reflux and delayed gastric emptying is
questionable (4-6) but it still is desirable to evaluate both in
one study. Many methods have been proposed to measure
gastric emptying: ultrasonic examination (7); epigastric imped
ance (8) and dual-isotope with combined solid and liquid meal
(9); and either liquid or formula (/ ). Of all these, the milk scan
is the most physiologic, allowing evaluation of gastroesopha
geal reflux and delayed gastric emptying in one setting. With
this procedure formula labeled with 99mTc-sulphur colloid
(99mTc-SC) is administered to the infant and images in the
posterior projection are gathered every minute seeking the
presence of gastroesophageal reflux. During the 1-hr acquisi
tion, the infant is in the supine position and gastric emptying is
assessed with the results reported as percent emptying or
retention at 1 hr or halftime emptying. The variability of these
results has been considerable and has cast doubt on the clinical
utility of the test in small infants (3-6,10-12).
In addition we encountered many discrepancies between
radiologie upper gastrointestinal series and nuclear gastric
emptying studies. We explored this discrepancy and decided
that positioning was a problem. The standard position in upper
gastrointestinal studies is right anterior oblique, with the right
side of the infant down, this enhances gastric emptying. Also,
this is more physiologic because babies are fed in the right
lateral semi-upright position.
In this study, at the end of 60 min supine imaging, we
gathered two additional views: one after changing the infant to
the right lateral decubitus, and another after holding the infant
1356 THEJOURNALOFNUCLEARMEDICINE•Vol. 37 •No. 8 •August 1996
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CONCLUSION

SPECT bone scanning of the knee is superior to planar imaging in detecting ACL injury and is a sensitive examination in a population of patients predominantly with chronic ACL tears. Sensitivity may be dependent on the chronicity of symptoms although acute tears and both partial and complete tears can be identified. Focal activity at either end of the ACL attachments may be seen, but the more common appearance is of a single, focal abnormality in the medial aspect of the posterior, lateral femoral condyle. This pattern has not been previously reported in patients with acute tears and may therefore occur more fre quently in those with chronic symptoms. SPECT imaging of the knee may be a valuable examination in suspected ACL injury particularly if MRI is not available, if MRI is equivocal or if the clinical signs do not support a diagnosis of ACL tears detected by MRI. In addition, knee SPECT is able to localize other areas of injury within the knee associated with ACL tears.

REFERENCES

  1. Holder LE, Machin JL, Asdourian PL, et al. Planar and high-resolution SPECT bone imaging in the diagnosis of facet syndrome. J NucÃ-Med l995;36:37-44.
  2. Ryan PJ, Evans P, Gibson T. Fogelman I. Chronic low back pain: comparison of bone SPECT, radiography and CT. Radiology 1992;182:849-854.
  3. Murray IPC. Dixon J. Kohan L. SPECT for acute knee pain. Clin NucÃ-Med 1990:15:828-840.
  4. Collier BD, Johnson RP, Carrera GF, et al. Chronic knee pain assessed by SPECT: comparison with other modalities. Radiology 1985:157:795-802.
  5. Fajman WA, Diehl M, Dunaway E, et al. SPECT for acute knee pain [Abstract]. J NucÃ- Med 1985:26:77.
  6. Chissell HR. Allum RL, Keightley A. MRI of the knee: its cost-effective use in a district general hospital. Ann R Coll Surg Engl. 1994;76(l):26-29.
  7. Reicher MA, Hartzman S. Bassett LW. et al. MRI imaging of the knee. Traumatic disorders. Radiology 1987:162:547-551.
  8. Le Vot J, Solacroup JC, Leonetti. et al. Correlations between clinical examination. MRI and arthroscopy in acute traumatic knees. J Radio! 1993:74:483-492.
  9. Mink JH. Levy T, Crues JV. Tears of the anterior cruciate ligament and menisci of the knee: MR imaging evaluation. Radiology 1988:167:769-774.
  10. Herman LJ, Beltran J. Pitfalls in MR imaging of the knee. Radiology 1988:167:775-
  11. Selesnick FH, Noble HB, Bachman DC, Steinberg FL. Internal derangement of the knee: diagnosis by arthrography. arthroscopy and arthrotomy. Clin Orihop 1985:198: 26-30.

Pediatrie Gastric Emptying: Value of Right Lateral

and Upright Positioning

Javier Villanueva-Meyer, Leonard E. Swischuk, Fernando Cesani, Seham A. Ali and Elma Briscoe Sections of Nuclear Medicine and Pediatrie Radiology, Department of Radiology, University of Texas Medical Branch, Galveston, Texas

Gastroesophageal reflux and gastric emptying are usually assessed simultaneously with a 1-hr procedure. After ingestion of radiolabeled formula sequential images are gathered when the infant is in the supine position. This position is adequate for gastroesophageal reflux assessment, but delays gastric emptying. Methods: We studied 48 children, 1 wk to 2 yr of age, who presented with vomiting or failure to thrive. They received 99mTc-sulphur colloid in formula. After completing 1 hr supine imaging we obtained additional ab dominal views after changing the position of the infant to right lateral for 30 min, and upright for another 30 min. Results: The percent of gastric emptying at 60 min in the supine position was 35% ±19%. At 90 min, in the right lateral decubitus, the percent gastric emptying was 60% ±25%. At 120 min, after an upright period, the gastric emptying was 73% ±20%. In the supine position 19 of 48 patients showed significant emptying (defined as >40% emptying). This increased to 41 of 48 normal studies considering the right lateral position and to 45 of 48 normal studies considering the infant upright position. Conclusion: Many patients with delayed gastric emptying show significant emptying just by changing position. We routinely complement gastric emptying studies with delayed views in the right lateral and upright position. Key Words: delayed gastric emptying; pediatrie gastric emptying; gastroesophageal reflux; technetium-99m-sulphur colloid J NucÃ-Med 1996; 37:1356-

A concern in infants with recurrent pulmonary infections, failure to thrive and vomiting is the presence of gastroesopha geal reflux or delayed gastric emptying. Gastroesophageal reflux is routinely assessed with radionuclide scintigraphy or

Received May 22, 1995; revision accepted Sept. 7, 1995. For correspondence or reprints contact: Javier Villanueva-Meyer, MD, Section of Nuclear Medicine, UTMB, Galveston, TX 77555-0793.

pH probing (1,2). The pH probe is the most sensitive method but the radionuclide method, although less sensitive, is thought to be more physiologic and is widely used (3). The association of gastroesophageal reflux and delayed gastric emptying is questionable (4-6) but it still is desirable to evaluate both in one study. Many methods have been proposed to measure gastric emptying: ultrasonic examination (7); epigastric imped ance (8) and dual-isotope with combined solid and liquid meal (9); and either liquid or formula (/ ). Of all these, the milk scan is the most physiologic, allowing evaluation of gastroesopha geal reflux and delayed gastric emptying in one setting. With this procedure formula labeled with 99mTc-sulphur colloid (99mTc-SC) is administered to the infant and images in the posterior projection are gathered every minute seeking the presence of gastroesophageal reflux. During the 1-hr acquisi tion, the infant is in the supine position and gastric emptying is assessed with the results reported as percent emptying or retention at 1 hr or halftime emptying. The variability of these results has been considerable and has cast doubt on the clinical utility of the test in small infants (3-6,10-12). In addition we encountered many discrepancies between radiologie upper gastrointestinal series and nuclear gastric emptying studies. We explored this discrepancy and decided that positioning was a problem. The standard position in upper gastrointestinal studies is right anterior oblique, with the right side of the infant down, this enhances gastric emptying. Also, this is more physiologic because babies are fed in the right lateral semi-upright position. In this study, at the end of 60 min supine imaging, we gathered two additional views: one after changing the infant to the right lateral decubitus, and another after holding the infant

1356 THEJOURNALOFNUCLEARMEDICINE•Vol. 37 •No. 8 •August 1996

upright. With this protocol, we sought to identify those patients with true delayed gastric emptying from those with positional delayed emptying.

METHODS We recruited patients from the pediatrie clinic referred for gastric emptying studies. The patient's chief complaints were vomiting, failure to thrive, gastrointestinal bleeding and aspiration pneumo nia. Some patients had more than one clinical presentation. We excluded patients with a nasogastric tube, previous gastrointestinal surgery or technically inadequate studies. We studied 48 children (aged 1 wk to 4 yr, 20 boys and 24 girls). All studies were performed with the patient fasting at least 2 hr. We did not study normal control subjects. All patients received the type and amount of formula they usually consumed. We added to the preparation 18-37 MBq (0.5- mCi) 99mTc-sulphur colloid (99mTc-SC). It was not practical to standardize the formula because of specific dietary needs of some infants and because others were finicky. The volume ingested by mouth ranged from 5 to 50 ml. After consuming the labeled formula the infants consumed an aliquot of nonradionuclide for mula to clear activity from the mouth and esophagus. Within 5 min of consuming the formula, the infants were placed supine on an imaging table. The infants were firmly restrained to a comfortable supine position and did not change position for 1 hr. A large field of view gamma camera gathered images every 60 sec for 1 hr from the posterior projection. The camera used a low-energy, medium resolution collimator. The acquisition matrix was 64 X 64 pixels, 16 pixels depth. After completing the 1-hr supine acquisition, the infant was placed in the right lateral position for 30 min. At the end of this period, the infant was placed supine for 5 min and a static image gathered. Then the mother or nurse held the infant upright for 30 min. At the end of 30 min in the upright position, the infant was placed supine for 5 min and another posterior image was gathered. To determine gastroesophageal reflux, the sequential supine images, from the first hour, were reviewed in a cine loop. Image interpretation was done from the monitor lowering the threshold to detect any esophageal activity. For the gastric emptying analysis, we condensed frames to 5-min intervals. This gave high-count

density and improved resolution for stomach region of interest definition. We analyzed images at four time intervals: TO = after completing the meal, T60 = at the end of 60 min supine, T90 = after 30 min in the right lateral position and T120 = after 30 min

upright. Decay correction was used for all measurements. A calculation of the percent gastric emptying at T60, T90 and T was done. We defined normal gastric emptying as more than 40% emptying at 1 hr. We also considered normal the decrease to <40% from baseline when changing positions. We also estimated gastric emptying at 90 min (90) and 120 min ( 120). The estimations were derived from extrapolation of the first hour emptying rate to 90 and 120 min. These values estimate the gastric emptying assuming no change in position and maintaining a similar emptying rate than the one observed during the first hour in the supine position.

RESULTS The average emptying of the stomach in 48 patients at 60 min was 35% ± 19%. At 90 min, the average value was 60% ± 25% and at 120 min was 73% ±20% (Fig. 1). Placing the threshold at 40% emptying at 1 hr, 19 of 48 (40%) patients show normal gastric emptying. Waiting an additional 30 min and changing the infant to the right lateral position, the percent of patients with normal emptying increased to 85% (41 of 48). An additional 30 min in the upright position increases this

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1100

90 120 mm

FIGURE 1. Percent gastric emptying at the end of 60 min in the supine position; at 90 min after the formula feed and after a period in the right lateral position; and at 120 min after the upright period.

percent to 94% (45 of 48). The observed gastric emptying rate (90 and 120) was faster than the estimated emptying rate ( and 120) (p < 0.001) (Fig. 2).

DISCUSSION Children and neonates with gastrointestinal disorders are among the most frequently seen by the pediatrician. The

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FIGURE 2. Estimated and observed gastric emptying at 90 and 120 min. Estimated values are an extrapolation of the emptying rate in the first hour. The observed emptying rates are significantly faster when changing positions to the right lateral and uprightStudent's t-test). position (p < 0.005 and p < 0.01 by paired

PEDIATRICGASTRICEMPTYING•Villanueva-Meyer et al. 1357