Docsity
Docsity

Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity


Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan


Guidelines and tips
Guidelines and tips

NURS 660 Exam Review (2) Correct Study Guide 2022, Study Guides, Projects, Research of Nursing

NURS 660 Exam Review (2) NURS 660 Exam Review (2) NURS 660 Exam Review (2) NURS 660 Exam Review (2) NURS 660 Exam Review (2)

Typology: Study Guides, Projects, Research

2021/2022

Available from 05/25/2022

NursingGrader001
NursingGrader001 ๐Ÿ‡บ๐Ÿ‡ธ

5

(2)

203 documents

1 / 40

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
NURS 660 Exam Review (2) Correct Study Guide
pf3
pf4
pf5
pf8
pf9
pfa
pfd
pfe
pff
pf12
pf13
pf14
pf15
pf16
pf17
pf18
pf19
pf1a
pf1b
pf1c
pf1d
pf1e
pf1f
pf20
pf21
pf22
pf23
pf24
pf25
pf26
pf27
pf28

Partial preview of the text

Download NURS 660 Exam Review (2) Correct Study Guide 2022 and more Study Guides, Projects, Research Nursing in PDF only on Docsity!

NURS 660 Exam Review (2) Correct Study Guide

50 questions, all multiple choice, 120minutes to complete it Covering weeks 6 (mood disorders), 7 (antidepressants), and 8 (mood stabilizers)

Major Content Areas:

  • (^) Drug side effects โ€“ 10-15 questions
  • (^) Drug-drug interactions โ€“ 5-7 questions
  • (^) Mechanism of Action โ€“ 10-15 questions
  • (^) Labs/monitoring โ€“ 3-5 questions
  • (^) Medical emergencies (toxicity, overdose, etc.) โ€“ 3-5 questions
  • (^) Neuroanatomy โ€“ 2-3 questions

MDD and brain neuroanatomy

  • (^) SSRIs:

An tid epressa n tCsita:lopram, Escitalopram, Paroxetine,

Fluoxetine, Fluvoxamine, Sertraline,

  • (^) Amitriptyline
  • (^) Bupropion
  • (^) Citalopram
  • (^) Clomipramine
  • (^) Duloxetine
  • (^) Escitalopram
  • (^) Fluoxetine
  • (^) Fluvoxamine
  • (^) Paroxetine
  • (^) Sertraline
  • (^) Trazodone
  • (^) Venlafaxine
    • (^) SNRIs: Duloxetine, Venlafaxine
    • (^) TCAs: Amitriptyline, Clomipramine,
    • (^) Other: Trazodone, Bupropion, Mirtazapine

SSRIs: 6 drugs โ€“ 1 common

property, individual differences

  • (^) All SSRIs work by selectively and potently inhibiting serotonin reuptake
  • (^) They all inhibit the serotonin

transporter aka SERT

  • (^) Each SSRI has secondary pharmacological actions besides the shared action of blocking SERT.
  • (^) No two SSRIs have identical secondary pharmacological characteristics
  • (^) Itโ€™s unclear if these secondary actions account for differences in efficacy/tolerability in each patient experience

Fluoxetine

  • (^) 5HT2C antagonism is unique to Prozac
  • (^) Blocking 5HT2C enhances the

release of NE and DA

  • (^) May be activating/energizing
  • (^) Improve concentration/motivation
  • (^) VERY long half-life (2 weeks)
  • (^) Good for noncompliant patients
  • (^) Bad in that it takes a long time to clear completely

Sertraline

  • (^) Dopamine transport and Sigma- 1 receptor binding are unique to Sertraline - (^) May be helpful for atypical depressive symptoms such as hypersomnia, anergia, and mood reactivity - (^) Sigma-1 may help with anxiolytic effects and addressing psychotic/delusional depression

Fluvoxamine

  • (^) Like sertraline in that it works on Sigma-1 (more potently)
  • (^) No FDA indication for depression

Escitalopram

  • (^) Only the โ€œSโ€ enantiomer and

no antihistaminic properties

  • (^) No dose restrictions, no QTc prolongation risk
  • (^) Works purely on SERT
  • (^) Tends to be best tolerated

SSRI, very few CYP- interactions

SNRIs: 4 drugs

  • (^) Work like SSRIs in that they all inhibit SERT
  • (^) Each also inhibits norepinephrine transport (NET) to various degrees
  • (^) SNRIs also act on dopamine specifically in the prefrontal cortex without inhibiting dopamine transporter (DAT) - (^) Blocking NE enhances and increases DA in the prefrontal cortex - (^) Less likely to have weight gain - (^) May increase blood pressure, urinary retention, sweating - (^) Venlafaxine - (^) Desvenlafaxine - (^) Duloxetine - (^) Levomilnacipran

Desvenlafaxine

  • (^) An active metabolite of venlafaxine
  • (^) Has greater NET vs 5HT

compared to venlafaxine

Duloxetine

  • (^) SERT > NET (slightly)
  • (^) Changed the way we think about

pain (psychic vs somatic)