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NURS 615 Advanced Pharmacotherapeutics Practice Exam 3 QUESTIONS AND CORRECT ANSWERS (VE, Exams of Nursing

NURS 615 Advanced Pharmacotherapeutics Practice Exam 3 QUESTIONS AND CORRECT ANSWERS (VERIFIED ANSWERS) PLUS RATIONALES 2025 MARYVILLE UNIVERSITY

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2024/2025

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NURS 615 Advanced Pharmacotherapeutics
Practice Exam 3 QUESTIONS AND CORRECT
ANSWERS (VERIFIED ANSWERS) PLUS
RATIONALES 2025 MARYVILLE UNIVERSITY
1. A patient taking lisinopril should be monitored for which serious
adverse effect?
Hyperglycemia
Hyperkalemia
Hypocalcemia
Hypernatremia
Lisinopril, an ACE inhibitor, can increase potassium levels due to
reduced aldosterone secretion.
2. Which antibiotic class is contraindicated in children under 8 due to risk
of permanent teeth discoloration?
Cephalosporins
Tetracyclines
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NURS 615 Advanced Pharmacotherapeutics

Practice Exam 3 QUESTIONS AND CORRECT

ANSWERS (VERIFIED ANSWERS) PLUS

RATIONALES 2025 MARYVILLE UNIVERSITY

  1. A patient taking lisinopril should be monitored for which serious adverse effect?
  • Hyperglycemia
  • Hyperkalemia
  • Hypocalcemia
  • Hypernatremia Lisinopril, an ACE inhibitor, can increase potassium levels due to reduced aldosterone secretion.
  1. Which antibiotic class is contraindicated in children under 8 due to risk of permanent teeth discoloration?
  • Cephalosporins
  • Tetracyclines
  • Macrolides
  • Aminoglycosides Tetracyclines can bind to calcium in developing teeth, leading to discoloration and enamel hypoplasia.
  1. Which medication is first-line for generalized anxiety disorder?
  • Bupropion
  • Escitalopram
  • Diazepam
  • Propranolol SSRIs like escitalopram are considered first-line due to efficacy and safety for long-term use.
  1. What is the mechanism of action of warfarin?
  • Platelet aggregation inhibitor
  • Vitamin K antagonist
  • Direct thrombin inhibitor
  • Factor Xa inhibitor Warfarin inhibits synthesis of vitamin K-dependent clotting factors II, VII, IX, and X.
  1. Which of the following is a beta-1 selective blocker?
  • Metoprolol
  • Diabetes
  • Agranulocytosis
  • Hypertension
  • Bradycardia Clozapine can severely suppress white blood cell count, necessitating regular CBC monitoring.
  1. Which drug is contraindicated with sildenafil use?
  • Beta-blockers
  • Nitrates
  • Diuretics
  • ACE inhibitors Sildenafil and nitrates together can cause life-threatening hypotension due to vasodilation.
  1. First-line treatment for hypertension in African American adults includes:
  • Calcium channel blockers
  • ACE inhibitors
  • Beta blockers
  • Alpha blockers CCBs and thiazides are more effective due to reduced renin activity in this population.
  1. Which drug can cause gingival hyperplasia?
  • Phenytoin
  • Valproic acid
  • Carbamazepine
  • Lamotrigine Phenytoin stimulates fibroblast proliferation, leading to gum overgrowth.
  1. What is the antidote for benzodiazepine overdose?
  • Naloxone
  • Flumazenil
  • Protamine sulfate
  • Atropine Flumazenil competitively inhibits benzodiazepine binding at the GABA receptor.
  1. Which antidepressant is associated with the highest risk of sexual dysfunction?
  • Bupropion
  • Paroxetine
  • Mirtazapine
  • Beta blockers
  • ARBs Beta blockers can blunt adrenergic warning signs like tremor and tachycardia.
  1. Which antibiotic has a risk for QT prolongation?
  • Amoxicillin
  • Ceftriaxone
  • Azithromycin
  • Doxycycline Macrolides like azithromycin prolong the QT interval by affecting cardiac potassium channels.
  1. What is the preferred treatment for acute gout attack?
  • Colchicine
  • Allopurinol
  • Probenecid
  • Febuxostat Colchicine is effective in reducing inflammation during acute gout flares.
  1. Which medication is used to reverse opioid-induced respiratory depression?
  • Flumazenil
  • Nalmefene
  • Naloxone
  • Methadone Naloxone is a competitive opioid antagonist that rapidly reverses CNS and respiratory depression.
  1. A common side effect of SSRIs is:
  • Weight loss
  • Gastrointestinal upset
  • Bradycardia
  • Blurred vision Increased serotonin levels can stimulate GI receptors, causing nausea and diarrhea.
  1. What is the therapeutic range for digoxin in heart failure?
  • 2.0–2.5 ng/mL
  • 1.5–2.5 ng/mL
  • 0.8–2.0 ng/mL
  • 0.5–0.9 ng/mL Lower levels are preferred in heart failure to reduce toxicity without compromising efficacy.
  • Mood changes Corticosteroids typically cause hypertension due to fluid retention, not hypotension.
  1. What is the preferred anticoagulant during pregnancy?
  • Warfarin
  • Low molecular weight heparin
  • Dabigatran
  • Rivaroxaban LMWH does not cross the placenta and is safe in pregnancy, unlike warfarin.
  1. Which of the following is a long-acting beta-agonist?
  • Salmeterol
  • Albuterol
  • Levalbuterol
  • Terbutaline Salmeterol has a long duration of action and is used in maintenance therapy for asthma/COPD.
  1. Which opioid is considered partial agonist and used in opioid dependence treatment?
  • Morphine
  • Buprenorphine
  • Codeine
  • Fentanyl Buprenorphine partially activates opioid receptors, helping with withdrawal symptoms.
  1. Which medication should be avoided in patients with G6PD deficiency?
  • Ceftriaxone
  • Sulfonamides
  • Penicillin
  • Clarithromycin Sulfonamides can trigger hemolysis in G6PD-deficient patients.
  1. Which class of drugs is most effective for lowering LDL cholesterol?
  • Statins
  • Fibrates
  • Niacin
  • Bile acid sequestrants Statins inhibit HMG-CoA reductase, significantly reducing LDL levels.
  1. What is a key adverse effect of amiodarone?
  • Hypoglycemia
  1. Which medication can induce a disulfiram-like reaction with alcohol?
  • Metronidazole
  • Clindamycin
  • Doxycycline
  • Linezolid Combining metronidazole and alcohol can cause nausea, flushing, and tachycardia.
  1. What lab value should be monitored in patients on clozapine?
  • Absolute neutrophil count (ANC)
  • Platelet count
  • ALT/AST
  • Creatinine Clozapine can cause agranulocytosis; ANC must be monitored regularly.
  1. What is a serious adverse effect of amlodipine?
  • Cough
  • Hypokalemia
  • Peripheral edema
  • Hyperglycemia Amlodipine causes vasodilation, which can lead to fluid leakage and peripheral edema.
  1. Which medication requires a slow titration to prevent Stevens- Johnson syndrome?
  • Lamotrigine
  • Topiramate
  • Valproic acid
  • Phenytoin Lamotrigine titration must be slow to minimize risk of life- threatening skin reactions.
  1. What is the black box warning for fluoroquinolones?
  • Tendon rupture
  • Liver failure
  • Bone marrow suppression
  • Vision loss Fluoroquinolones can damage tendons, especially in older adults or those on corticosteroids.
  1. What drug is used to reverse warfarin’s effects?
  • Protamine sulfate
  • Vitamin K
  • Folic acid
  • Vitamin B
  • Pyridoxine (B6)
  • Thiamine INH depletes vitamin B6, leading to neuropathy unless supplemented.
  1. What is a notable adverse effect of ACE inhibitors?
  • Bradycardia
  • Dry cough
  • Rash
  • Edema ACE inhibitors increase bradykinin, which can cause a persistent dry cough.
  1. Which medication can cause ototoxicity?
  • Amoxicillin
  • Gentamicin
  • Cefazolin
  • Azithromycin Aminoglycosides like gentamicin can damage inner ear structures.
  1. Which diabetic medication carries a risk for euglycemic ketoacidosis?
  • Glipizide
  • Empagliflozin
  • Sitagliptin
  • Pioglitazone SGLT2 inhibitors increase urinary glucose excretion, which can trigger ketosis despite normal glucose levels.
  1. What is the mechanism of action of alendronate?
  • Calcitonin agonist
  • Inhibits osteoclast-mediated bone resorption
  • Increases calcium absorption
  • Parathyroid hormone analog Alendronate is a bisphosphonate that slows bone breakdown.
  1. Which drug is a centrally acting alpha-2 agonist?
  • Clonidine
  • Lisinopril
  • Losartan
  • Hydralazine Clonidine reduces sympathetic outflow, lowering blood pressure.
  1. What is the preferred treatment for community-acquired pneumonia in a healthy outpatient?
  • Vancomycin
  • Azithromycin
  • Cefepime
  • Linezolid Macrolides like azithromycin cover common pathogens in otherwise healthy patients.
  1. What adverse effect is associated with spironolactone?
  • Hypocalcemia
  • Gynecomastia
  • Hypoglycemia
  • Hyponatremia Spironolactone is an anti-androgen and may cause breast enlargement in males.
  1. Which medication is most likely to cause pancreatitis?
  • Lisinopril
  • Valproic acid
  • Amiodarone
  • Phenytoin Valproate can cause severe and potentially fatal pancreatitis.
  1. Which anticoagulant does not require INR monitoring?
  • Warfarin
  • Rivaroxaban
  • Heparin
  • Enoxaparin Rivaroxaban, a DOAC, has predictable pharmacokinetics and doesn’t require INR monitoring.
  1. What is a common side effect of tamoxifen?
  • Anemia
  • Hot flashes
  • Bradycardia
  • Visual disturbances Tamoxifen affects estrogen receptors, leading to menopausal symptoms like hot flashes.
  1. Which of the following drugs is used in status epilepticus?
  • Levetiracetam
  • Lorazepam
  • Carbamazepine