Understanding Nucleotides: Structure, Function, Synthesis, and Degradation, Summaries of Biochemistry

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Libyan International Medical University Faculty of Pharmacy Second Year Block VII

Nucleotides

Rayyan abbas Morad Walid

Objectives:

vDescribe the structure of Nucleotides

vList function of Nucleotides

vDescribe Nucleotide Synthesis

vDiscuss degradation of purine nucleotides

Function of Nucleotides

v Nucleotides are precursors of the nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). v Besides being the basic unit of genetic material for all living things. v Nucleotide can be a base in another molecule, such as adenosine triphosphate (ATP), which is the main energy molecule of the cell. v They are also coenzymes like NAD and NADP these molecules are used in many chemical reactions that play roles in metabolism.

Nucleotide Synthesis

v There are two pathways for the synthesis of

nucleotides:

1. De novo Synthesis of Purine Nucleotides.

2. Salvage Pathway.

Salvage Pathway

Salvage pathways recycle the free purines and purine nucleosides released from nucleic acid breakdown

Degradation of purine nucleotides

Summary

v Nucleotides are the basic building blocks of nucleic acids. v There are two pathways De novo and salvage pathway. v De novo pathway synthesis of purine nucleotide occurs in most of the tissue. v Salvage pathways recycle the free purines and purine nucleosides.