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NKU MSN 611 Final Exam new study set 2024 | Actual Questions and
Answers Latest Updated 2024/2025 (Graded A+)
Locations of H4 Receptors Answer✔✔H1 - Smooth Muscle Cells, Endothelium, and the brain H2 - Gastric Mucosa, Cardiac Muscle, Mast Cells, and the Brain H3 - The Brain h4 - Predominantly in Eosinophils, Neutrophils and T Cells 2nd Gen Antihistamine that cannot be removed by Hemodialiysis Answer✔✔Cetirizine Diagnosis of enterobiasis Answer✔✔Perianal Swab using adhesive tape that is examined microscopically for eggs Treatment modalities of Tuberculosis Answer✔✔Direct observed Therapy is a strategy to insure adherence to drug regimen According to the universal prescribing alert for aminoglycosides, extended use increases risk for infection by which pathogen Answer✔✔C. Diff Mode of administration of Dactinomycin Answer✔✔IV Route to prevent extravasation.. Should extravasation occur infusion should be stopped immediately FDA Approved indication of Methotrexate Answer✔✔Meningeal Leukemia Trophoblastic Neoplasms Breast Cancer Synthetic muscarinic receptor antagonist that possesses M3 receptor selectivity (2) Answer✔✔Darifenacin & Solifenacin
Autonomic agents associated stimulation of insulin production, increased glycogenolysis in the liver, and complicate management of Diabetes mellitus Answer✔✔Autonomic-sympathomimetic agents Most commonly used therapy for iron-deficiency anemia Answer✔✔Ferrous Sulfate Fatalities have occurred with the test dose of which drug Answer✔✔Iron Dextran Antilipemic agent that target triglycerides Answer✔✔Fibrates Mechanism of action of calcium channel blocking agents Answer✔✔Act on calcium channels in large vessels to produce vasodialation and subsequent reduction in BP Hypotensive agent FDA Approved for treatment of ADHD Answer✔✔Guanfacine When prescribing benzodiazepines, only lorazepam, oxazepam, or temazepam should be considered for which patents Answer✔✔Those with Hepatic impairment Indication of Lithium Answer✔✔Mood Stabilizer used to treat patients who experience mania and or depressive symptoms Important consideration when administering total parenteral nutrition peripherally Answer✔✔TPN delivered through a peripheral line must have a lower osmolality in order to be safe for patients Due to the high concentration of ingredients there is a risk of damaging peripheral veins due to phlebitis Mechanism of action of Thiazide-like diuretics Answer✔✔Work in distal tubule in inhibiting re absorption of sodium chloride to draw water into collecting duct Etiology of bronchospasm in asthma patients Answer✔✔bronchiospasms occur as the stimulus interacts with arachidonic acid
Description and mode of action of topical anti-infective agents Answer✔✔Provides treatment directly to the infected location without risking significant systemic side effects Potential side effects associated with isotretinoin Answer✔✔Marked elevation of serum triglycerides Side effects of Miirabegron Answer✔✔Tachycardia & Arrhythmias Substance structurally related to Methylxanthines Answer✔✔Caffeine Signs / symptoms of Theophylline toxicity Answer✔✔repetitive vomiting Intranasal products should be used right after a patient has tried to _______________ and are more effective when used regularly Answer✔✔intranasal glucocorticoid Most signi8ficant adverse reaction associated with the use of hemotopoietic agents Answer✔✔Infusion related reactions such as Hypotension and bradycardia Sildenafil's mechanism of action is to inhibit PDE-5 and increase intracellular concentration of __________________________. Answer✔✔cGMP Cyclic guanosine monophosphate Drug - drug interactions between 1st gen anttihistamines and moniamine oxidase and appropriate prescribing protocol of 1st gen antihistamines to patients who take MAOIs Answer✔✔1st gen antihistamines should not be used during treatment of MAOIs or within 2 weeks of MAOI discontinuation In the stomach, histamine is released by what Answer✔✔Enterochromaffin - like cells When does tumor flare occur and associated symptoms Answer✔✔Tumor Flare is a side effect that may occur during the initial phase of hormonal treatment symptoms can include sudden and painful increase to tumor size
rash low grade fever hypercalcemia bone pain increased marker levels Potential side effects of autonomic-anticholinergic agents in older males Answer✔✔exacerbation of symptoms of benign prostatic hypertrophy FDA approved drug for Alzheimers disease Answer✔✔Donepezil Dosing schedule for oral and intramuscular naltrexone and the most appropriate types of patients Answer✔✔Patients with a Hx of opiate / alcohol abuse or dependence Oral should be administered Daily Intramuscular every 4 weeks Number of Muscarinic Receptors Answer✔✔ 5 Effectiveness of centrally acting skeletal muscle relaxants Answer✔✔Action of centrally acting skeletal muscle relaxants is associated with the interrupted communication of neurons within the CNS and not a direct effect on the muscle tissue In the sequential thrombin amplification process, activated thrombin induces production of Answer✔✔Fibrin Mechanism of action and indication of Dornase Alfa Answer✔✔Enzyme that decreases the viscosity of sputum and is used to augment the body's natural mucolytic processes Dosage consideration of Histamine 2 receptor antagonists relative to their ability to cross the blood brain barrier Answer✔✔Dosage adjustments should be made in patients with renal insufficiency
Indication of systemic chemotherapy given prior to surgery or radiation Answer✔✔Reduce tumor burden and increase effectiveness of the local treatment Management of tumor lysis syndrome leukemia patients Answer✔✔IV Hydration Acrolein is a toxic metabolite of cyclophosphamide and ifosfamide that can cause: Answer✔✔hemorrhagic cystitis Antineoplastic drugs offer an alternative when traditional treatments fail Answer✔✔immunosuppressants Topoisomerase inhibitors target enzymes thaat control changes in DNA Answer✔✔structure Effects of cholinesterase inhibitors on the SA and AV nodes Answer✔✔Vagotonic Mechanism of action of "mixed acting" sympathomimetic drugs Answer✔✔Facilitate the release, block the transport, decrease metabolism or "imitate" actions of norepinephrine Indications of GAABA-derivitave antispasmidic agents used effectively to control muscle spasms Answer✔✔Muscular Sclerosis FDA-approved use for belladonna Answer✔✔Moderate pain to severe pain associated with ureteral spasm (bladder spasm) not responsive to non-narcotic analgesics After the 1st dose of warfarin, how much time is required for therapeutic effects to begin Answer✔✔ 5 - 7 days The function of plasmin is to Answer✔✔breaking cross links between fibrin Sources of most antihemorrhagic agents Answer✔✔human sources
Primary causative factor for crohn's disease Answer✔✔Unknown Drug is FDA approved for thrombocytopenia Answer✔✔Oprelvekin Type of hypertensive medication should preferentially be considered for African Americans Answer✔✔Thiazide-type diuretics Drug of choice for treating hypertension in pregnancy Answer✔✔Methyldopa Beta blocker indicated for hypertensive emergencies Answer✔✔Labatalol Mechanism of action of renin-angiotensin-aldosterone inhibitors Answer✔✔some can reduce ventricular hypertrophy Therapeutic management of paroxysmal superventricular tachycardia Answer✔✔Adenosine Commercially available probiotics have shown some benefit for preventing infection with which organism Answer✔✔C. diff Adverse effects of chronic phenytoin use Answer✔✔Osteomalacia Drugs in the anxiolytic, sedative and hypnotic category that is a melatonin agonist Answer✔✔Ramelteon The 'tripans' exert the serotonin 1B and sertonin1D agonsit effect in the Answer✔✔brainstem Indication of 1st gen antihistamines as antiemetic Answer✔✔motion sickness
Describe the most common adverse effects of Ferrous Sulfate Answer✔✔Flushing and GI - nausea and constipation Describe the mechanism of action of pentoxidfylline Answer✔✔Decrease viscosity of blood to improve flow Clinical indication of pentoxidfylline Answer✔✔Improves symptoms due to intermittent claudication Primary indication for Verapamil and diltiazem are prescribed and for potential side effects or complications Answer✔✔for Rate control with arrhythmias side effects - bradycaradia heart failure exacerbation Av block Mechanism of action of hemorrheologic Answer✔✔Decrease viscosity off blood to improve flow properties
