NGR 6172 TEST 1 Practice Questions
1. Some drugs can stimulate metabolizing enzymes and speed up their metabolism which
can lower the actual effect of drugs. Which of the following drugs are known as inducing
agents (select all that apply)
a) Atorvastatin
b) Phenytoin
c) Tobacco
d) St. Johns wort
2. QT prolongation can occur with some drugs and combinations of drugs. Which of the
following increase the risk of QT prolongation and potential dysrhythmias (select all that
apply)
a) Male gender
b) Female gender
c) Hypokalemia
d) Low magnesium
3. Sudden withdrawal of a medication that has been used chronically can create a
hypersensitivity reaction. Which of the following are sensitivity responses that can occur
when the medication is stopped (select all that apply)
a) Abrupt cessation of metoprolol can lead to HTN
b) Abrupt cessation of clonidine can lead to tachycardia
c) Abrupt cessation of clonidine can lead to hypertension
d) Abrupt cessation of metoprolol can lead to tachycardia
4. Match the pharmacodynamic term with the definition:
a) ED50 - The dose that is required to produce a defined therapeutic response in
50% of the population
b) Receptor downregulation - Desensitizing occurs when the receptors of a cell are
continually exposed to an agonist (molecules that activate receptors or drugs that
mimic the body’s response) the cell becomes less responsive
c) Partial agonist or agonist-antagonist - An agonist that has less effect than a full
agonist.
d) Therapeutic index - Ratio of a drug’s LD50 (which is average lethal dose in 50%
on animals tested) to its ED50 (therapeutic dose in 50% of a population)
e) Idiosyncratic response - An uncommon drug response resulting from a genetic
predisposition
f) Bioavailability - The ability of a drug to reach the systemic circulation from its
site of administration
g) Tachyphylaxis - A form of tolerance that can be defined as a reduction in drug
responsiveness brought on by repeated dosing over a short time
