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The "NBDHE Pharmacology Exam 2025" document is a comprehensive guide designed to assist dental hygiene students in preparing for the National Board Dental Hygiene Examination (NBDHE). This resource provides a detailed overview of pharmacology-related questions and their correct answers, focusing on key areas of dental anesthesia, systemic medications, and their applications in dental practice. The document begins by addressing local anesthetics (LAs) used in dentistry, highlighting mepivacaine as the anesthetic with the shortest duration and lidocaine as both the most common LA and safe option for use during pregnancy. It further discusses the maximum recommended dose (MRD) for lidocaine and epinephrine, emphasizing their clinical significance.
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What LA has the shorted duration? ---------CORRECT ANSWER----------------- mepivicaine What anesthetic is safe in pregnancy? ---------CORRECT ANSWER----------------- lidocaine What is the most common LA in dentistry? ---------CORRECT ANSWER----------------- lidocaine What is the MRD for lidocaine? ---------CORRECT ANSWER-----------------3mg/lb. max of 500mg MRD for epi in a healthy individual ---------CORRECT ANSWER-----------------.2mg
MRD for Epi in an immunocomp individual ---------CORRECT ANSWER----------------- .04mg (about 2 cartridges) T/F epi is contraindicated in a pt with controlled hypertension ---------CORRECT ANSWER-----------------false. What LA is 4% (compared to the typical 2%) ---------CORRECT ANSWER----------------
What dangerous syndrome is found in children with the flu or chic pox who take aspirin? ---------CORRECT ANSWER-----------------Reyes syndrome What may happen at high doses of aspirin? ---------CORRECT ANSWER----------------- tinnitus Brand name acetaminophen ---------CORRECT ANSWER-----------------Tylenol Effects of acetaminophen ---------CORRECT ANSWER-----------------Analgesic Antipyretic What does Tylenol not do? ---------CORRECT ANSWER-----------------It is not anti- inflammatory Adverse effects of Tylenol ---------CORRECT ANSWER-----------------Hepatoxicity Analgesic drug of choice for children ---------CORRECT ANSWER----------------- Tylenol
Analgesic drug for patients on anticoagulants ---------CORRECT ANSWER-------------- ---Tylenol Analgesic drug for patients with ulcers ---------CORRECT ANSWER----------------- Tylenol Analgesic of choice for post NSPT pain ---------CORRECT ANSWER----------------- Tylenol Dangers of high doses of acetaminophen ---------CORRECT ANSWER----------------- hepatoxicity and liver necrosis Ibuprofen is known as a ---------CORRECT ANSWER-----------------NSAID Adverse effects of ibuprofen includes ---------CORRECT ANSWER----------------- gastric upset, and interference with clotting Brand names of ibuprofen ---------CORRECT ANSWER-----------------advil and motrin
Potency is related to ---------CORRECT ANSWER-----------------dose. Potency is greater when a dose is smaller Efficacy is ---------CORRECT ANSWER-----------------the maximum response of a drug regardless of dose What is first past effect? ---------CORRECT ANSWER-----------------When orally administered drugs pass through the hepatic portal which reduces the amount effective drug. this requires large doses of a drug What drug administration route is used to deliver protein products? --------- CORRECT ANSWER-----------------Subcutaneous The TB skin test is an example of what route of drug administration? --------- CORRECT ANSWER-----------------Intradermal The study of how we drug enters the body, circulates in the body and leaves the body ---------CORRECT ANSWER-----------------pharmacokinetics What organ is involved in absorption of oral drugs? ---------CORRECT ANSWER------ -----------small intestine
What is the most important site for metabolism of drugs? ---------CORRECT ANSWER-----------------the liver What is the most important organ that is involved in excretion? ---------CORRECT ANSWER-----------------kidneys What terminates drug effects? ---------CORRECT ANSWER-----------------elimination What steps do intra-vascular drugs bypass? ---------CORRECT ANSWER----------------- absorption and first pass What drugs are known to move across biological membranes by diffusion? --------- CORRECT ANSWER-----------------Lipid soluble drugs Metabolism is also known as ---------CORRECT ANSWER-----------------Bio transformation
The Post ganglionic neurotransmitter for the sympathetic nervous system is ------- --CORRECT ANSWER-----------------Norepinephrine What drugs mimic the sympathetic nervous system? ---------CORRECT ANSWER----- ------------Adrenergic drugs What diseases should avoid adrenergic drugs? ---------CORRECT ANSWER------------- ----angina, uncontrolled hypertension and uncontrolled hyperthyroidism What is dopamine used to treat? And what class of drugs is it? ---------CORRECT ANSWER-----------------Shock, Low blood pressure, parkinson's. adrenergic Andrenergic blocking drugs are used to treat ---------CORRECT ANSWER--------------- --High blood pressure, angina, glaucoma and myocardial infarction Propanolol is also known as: And it is a ---------CORRECT ANSWER-----------------Inderal Nonselective beta blocker to treat hypertension
Atenolol is also known as: And it is a ---------CORRECT ANSWER-----------------Tenormin Selective beta blocker to treat hypertension Lopressor is also known as And it is a ---------CORRECT ANSWER-----------------Metoprolol selective beta blocker to treat hypertension pilocarpine is an example of a: what two diseases can it treat? ---------CORRECT ANSWER-----------------cholinergic drug. It increases saliva flow in patients with sjogrens can also tx glaucoma what type of drugs are used to treat hypertension and angina? ---------CORRECT ANSWER-----------------adrenergic blocking what drugs are contraindicated for angina, uncontrolled hypertension and hyperthyroidism? ---------CORRECT ANSWER-----------------adrenergic drugs
what are the parameters for a schedule 2 drug? ---------CORRECT ANSWER----------- ------no refills, must be hand delivered with a signature what are the parameters for a schedule 3 drug? ---------CORRECT ANSWER----------- ------can be phoned in but can only have 5 refills in 6 months narcan is an ______________________ (drug class) ---------CORRECT ANSWER------ -----------opioid antagonist most common antibiotic in dentistry ---------CORRECT ANSWER----------------- penicillin bactericidal ---------CORRECT ANSWER-----------------kills bacteria bacteriostatic ---------CORRECT ANSWER-----------------stops bacteria from reproducing resistance ---------CORRECT ANSWER-----------------the ability of a microorganism to be unaffected by a drug
spectrum ---------CORRECT ANSWER-----------------the range of activity of a drug synergism ---------CORRECT ANSWER-----------------When the combination of two antibiotics produces a greater effect than would be expected if their individual actions were added antagonism ---------CORRECT ANSWER-----------------when the combination of two antibiotics produces a lesser effect than would be expected. How does penicillin work? ---------CORRECT ANSWER-----------------It is bacteriocidal it destroys the bacterial cell wall What is the most likely antibiotic to produce an anaphylactic allergic reaction? ---- -----CORRECT ANSWER-----------------penicillin is Penicillin safe for pregnant patients ---------CORRECT ANSWER-----------------yes what is augmentin? ---------CORRECT ANSWER-----------------penicillin and clavulanic acid
antibiotic that can be found in crevicular fluid ---------CORRECT ANSWER-------------- ---tetracyclines what antibiotic is similar to penicillin? ---------CORRECT ANSWER----------------- cephalosporins what two antibiotics have cross-allergenicity? ---------CORRECT ANSWER-------------- ---cephalosporins and penicillin what are the drugs that are used together to treat TB? ---------CORRECT ANSWER-- ---------------Rifampin isoniazid pyrazinamide ethambutol what 2 drugs may be used in TB prevention only? ---------CORRECT ANSWER--------- --------Rifampin or isoniazid
what is the 1st alternative if pt is allergic to amoxicillin for premed? --------- CORRECT ANSWER-----------------clindamycin what is a rare adverse reaction of clindamycin? ---------CORRECT ANSWER------------ -----pseudomembranous colitis what antibiotic may have an antibuse effect with alcohol? ---------CORRECT ANSWER-----------------metronidazole (flagyl) flagyl is ---------CORRECT ANSWER-----------------metronidazole What is used in treatment of ANUG and perio infections? ---------CORRECT ANSWER-----------------metronidazole and tetracycline premed for a shunt or a stent? ---------CORRECT ANSWER-----------------shunt what immuncompromised patients may require premed? ---------CORRECT ANSWER-----------------Iv drug users, AIDs, uncontrolled diabetes
what family of anesthetic is used in dentistry mostly? ---------CORRECT ANSWER--- --------------amides where are amides metabolized? ---------CORRECT ANSWER-----------------the liver where are esthers metabolized? ---------CORRECT ANSWER-----------------blood plasma what LA has the longest duration? ---------CORRECT ANSWER----------------- bupivicaine (marcaine) what LA has an increased risk of paraesthesia, especially in the mandibular block? ---------CORRECT ANSWER-----------------articaine (septocaine) mepivicaine is aka ---------CORRECT ANSWER-----------------carbocaine prilocaine is aka ---------CORRECT ANSWER-----------------citanest lidocaine is aka ---------CORRECT ANSWER-----------------xylocaine
bupivicaine is aka ---------CORRECT ANSWER-----------------marcaine articaine is aka ---------CORRECT ANSWER-----------------septocaine what dental drug should not be used in patients taking tricyclic antidepressants? name a tricyclic antidepressant ---------CORRECT ANSWER-----------------Elavil (amitriptyline) _______% of patients have gingival enlargement with phenytoin(dilantin) --------- CORRECT ANSWER----------------- 50 what is the effect of phenobarbital? ---------CORRECT ANSWER----------------- sedation what can be used to treat trigeminal neuralgia? ---------CORRECT ANSWER----------- ------carbamazepine