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Mutations Worksheet
Part 1: Gene Mutations In the chart below, transcribe the DNA sequence into mRNA. Then use the codon chart (below) to indicate what amino acids are being coded for by the base sequences listed for the mRNA. Then, tell what type of gene mutation is being illustrated. Choose from point mutation and frameshift mutation. Type of Mutation DNA sequence TACGCCAGTGGT mRNA sequence Original Amino Acids DNA sequence TACCCCAGTGGT mRNA sequence Amino Acids DNA sequence TACCCAGTGGT mRNA sequence Amino Acids
Part 2: Chromosome Mutations For each diagram below, indicate what type of chromosome mutation is illustrated. Choose from: deletion, insertion/duplication, inversion, and translocation
A.
B.
C.
D.
For numbers 1-5, choose from the following terms. Insertion Inversion Deletion Substitution Point Mutation Translocation
- Name the three types of point (gene) mutations:
- Name the four types of chromosome mutations:
- What mutations would be considered frameshift mutations?
- Which mutation involves two chromosomes?
- Can a point mutation be a frameshift mutation?
Match the following terms to the descriptions below. A. Deletion B. Frameshift mutation C. Insertion D. Inversion E. Mutagen F. Point mutation (gene mutation) G. Substitution H. Translocation
_____ 1. A mutation that involves one or a few nucleotides.
_____ 2. Involves the loss of all or part of a chromosome or one base.
_____ 3. Produces extra copies of parts of a chromosome or a base.
_____ 4. Reverses the direction of parts of chromosomes.
_____ 5. Occurs when part of one chromosome breaks off and attaches to another.
_____ 6. Affects the DNA sequence of an entire chromosome.
_____ 7. A substance that can change the chemical nature of DNA.
_____ 8. One base is exchanged for another.
For numbers 9 and 10, choose from the following terms:
A. Frameshift mutation
B. Point mutation
_____ 9. A DNA segment is changed from AAGGACATTAGC to AGGACATTAGC
_____ 10. A DNA segment is changed from GGTCAT to GGGCAT
