Biosynthesis
of
Membrane
Phospholipids
Phosphatidic
acid/diacylglycerol
Attach
head
group
to
0-3
OH
group
bracylglycerolate
to
C-3
->
OH;
head
group
->
OH
With
not
on
Queen
ene
New
phospho-headgroup
->
phosphoric
acid
condenses
with
2
alcohols
Eliminates
2
He
0
e
Attaching
Phospholipid
Head
group
->
Activation
by
CDP
Either
one
of
the
alcohols
is
activated
by
attaching
to
CDP
(cytidine
diphosphate)
free
alcohol
->
nucleophilic
attack
on
CDp-activated
phosphate
42C-0-p-
0-
ne
Phosphodiester
Strategy/
Glycerophospholipid
placylglycerol
activated
with
CDP
-
-
-
R
actheartached
cor
Phospholipid
Synthesis
in
E.
Coli
!
⑲
"
-0
-
0
-
R2
-
-
-R2
ac-o
*
no-ren
-
Head
phosphatidylserine
->
synthesized
+
can
be
decarboxylated
to
H2C-OM
-O-P-0-
So
12-Dlacylglycerol
60
group
Phosphatidylethanolamine
0
=
1
0
=
Sine
W
r
ne
phosphatidylglycerol
->
synthesized
by
addition
of
CDP-glycerol
W
cpp.
diacylglycerol
(MP
meta
te
-
3-phosphate
I
Head
act
of
boron
at
further
modification
to
cardioliph
->
replacement
of
glycerol
head
group
with
another
phospholipid
i
-
m
mac-o-prp,
much
nee
Phospholipid
synthesis
in
Eukaryotes
MC
-
0
-
1.
-
↳---ine
ans-oo
e
at
often
re
slightly
different
mc-o--o--one
which
are
center
the
from
bacterial
Phosphatidylserine
synthesis
strategy
E
phosphatidylglycero
enterested
acylglycerases
th
decarboxeias
econ
(e.g,
replacement
of
CMP,
rather
than
glycerol)
Host
he
mac
of
a
ne
-ocee
e
water
one-cus-the
e
Hel-o-O-CHz--ch
Phosphatidylglycerol
Phosphatidylethanolamine
and_o-o-
om
cardchPseis)(ePhatidylglycerol
drz-8--0-CH,
o
II
-O-c-
R2
!
mp
0
ac-o-down
the
e
via
a
ne
Mic
-o
-
!
-
R1
&H
groups
can
also
be
Phosphatidylinositol
phosphorylated
duz-o_po--
curdidip
in
His-o--ri
