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MN553 / MN553: Advanced Pharmacology & Pharmacotherapeutics Unit 2 Quiz Study Guide (Latest, 2022/2023)
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MN553 Advanced Pharmacology & Pharmacotherapeutics Unit 2 Quiz Study Guide
- D/t Cerbrovascular Pgp activity being reduced, greater penetration of drugs in the CNS and expose brain to elevated levels of some drugs and toxins. o Metabolism: ▪ Most drug metabolism occurs in liver. ▪ Drug clearance in liver depends on hepatic blood flow and enzyme activity. ▪ Age causes decrease in liver size, blood flow, and metabolism. - More pronounced in malnourished frail elders ▪ Propranolol, verapamil, and diazepam undergoes extensive first pass metabolism (P450) sometimes poorly tolerated by older adults. ▪ Decreased hepatic clearance can result in significant increase in the bioavailability and half-life of drugs, d/t relying on high rates of blood flow through the liver for extraction. o Excretion: ▪ Most drugs are eliminated through the kidneys. ▪ Dosing guidelines available to help providers make appropriate adjustments for renal impairment. ▪ Serum Creatinine most reliable to determine kidney function. Not reliable in older adults malnutrition can affect this test. ▪ BUN requires adequate protein ingestion.