Download MMSC423 Hematology1 EXAM QUESTIONS AND ANSWERS UPDATED (2025/2026) (VERIFIED ANSWERS) and more Exams Hematology in PDF only on Docsity!
MMSC423 Hematology 1 EXAM QUESTIONS
AND ANSWERS UPDATED (202 5 /202 6 )
(VERIFIED ANSWERS)
ADP is secreted from the: dense granules beta granules delta granules alpha granules correct answers dense granules Factor III is known as prothrombin time calcium christmas factor tissue factor correct answers tissue factor Which of the following is true regarding the plasma coagulation zymogens?
- are haptens that induce peptide binding to make larger active molecules
- activation normally occurs throughout the tissues of the body when vascular injury occurs
- serine proteases that form complexes to activate other zymogens to ultimately generate thrombin
- circulate normally in their active form correct answers serine proteases that form complexes to activate other zymogens to ultimately generate thrombin What reaction is essential in the production of vitamin K dependent coagulation factors? reduction of tryptophan oxidation of valine gamma carboxylation of glutamic acid dehydrogenation of leucine correct answers gamma carboxylation of glutamic acid Another name for Factor X is: Stuart-Prower Christmas Factor Fitzgerald Factor Hagemen Factor correct answers Stuart-Prower What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen? digested quickly by tissue plasminogen activator
converted to plasminogen immediately inactivated to prevent excess clotting polymerized and are stabilized by FXIIIa correct answers polymerized and are stabilized by FXIIIa A tube of anticoagulated blood was centrifuged. After centrifugation which of the following describes the correct sequence of layers from top to bottom of the tube? buffy coat, plasma, red blood cells buffy coat, red blood cells, plasma plasma, buffy coat, red blood cells red blood cells, buffy coat, plasma correct answers plasma, buffy coat, red blood cells Factor VII is known as: fibrinogen stable factor christmas factor labile factor correct answers stable factor Tissue Factor Pathway Inhibitor inactivates which factor? IIa I XIa VIIa correct answers VIIa What is the role of the thrombin-thrombomodulin complex? activates thrombin inhibits factor Xa activates protein C initiates vasoconstriction correct answers activates protein C Which of the following comprise the buffy coat? white blood cells and red blood cells fibroblasts and red blood cells lymphocytes and monocytes platelets and white blood cells correct answers platelets and white blood cells A thrombocyte refers to a: erythrocyte lymphocyte platelet monocyte correct answers platelet Antithrombin (AT) inactivates all of the following factors, except: FXI FX FI
thrombin Christmas Factor antihemophilic factor correct answers christmas factor Factor XIII is known as: Stuart-Prower Factor fibrin stabilizing factor antihemophilic factor labile factor correct answers fibrin stabilizing factor Which of the following are components of the contact group of factors? calcium and IX XII and prekallikrein VIII and vWF fibrinogen and thrombin correct answers XII and prekallikrein Factor XI is known as: Stuart-Prower factor plasma thromboplastin antecedent Labile factor Hageman Factor correct answers plasma thromboplastin antecedent This fragment of fibrinolysis is representative of plasmin's action on insoluble fibrin fragment X fragment Y fragment D D-dimer correct answers D-dimer What is the primary role of vWF? mediate platelet secretion mediate platelet aggregation mediate platelet adhesion activator of protein C correct answers mediate platelet adhesion What constituent of the peripheral zone contains glycoproteins responsible for blood group specificity (ABO), tissue compatibility, and platelet antigenicity? actin open canalicular system Golgi complex glycocalyx correct answers glycocalyx Which of the following is a receptor for fibrinogen on the platelet membrane? GPIVb/IIIa GPVa/Xb GPIIb/IIIa GPIb/IIIb correct answers GPIIb/IIIa
Tissue plasminogen activator converts plasminogen to plasmin on the surface of: fibrin clot thrombin urokinase fibrinogen correct answers fibrin clot Which of the following is the main substrate of the coagulation system? Factor VII Factor XII Factor I Factor II correct answers Factor I Factor VIII is known as: von willebrands factor anti hemophilic factor Christmas factor tissue factor correct answers anti hemophilic factor All of the following is considered part of the vascular response in the hemostatic process, except: vasoconstriction vasodilation adhesion release of von Willebrands factor from subendothelium correct answers vasodilation All of the following coagulation proteins are serine proteases, except: Plasma thromboplastin antecedent Hageman Factor Stuart-Prower fibrin stabilization factor correct answers fibrin stabilization factor Factor Va is part of: intrinsic tenase complex fibriniolysis prothrombinase complex extrinsic tenase complex correct answers prothrombinase complex Aspirin inhibits which of the following leading to impaired platelet aggregation? peptidase cyclooxygenase prostacyclin papain correct answers cyclooxygenase Which of the following cannot convert plasminogen to plasmin? thrombomodulin urokinase
water lipids proteins red blood cells correct answers red blood cells Factor I is also known as correct answers Fibrinogen Factor V is also known as correct answers labile factor Factor XII is also known as correct answers Hageman factor Factor IV is also known as correct answers calcium Contact group has the following factors correct answers XI, XII, PK, HMWK The prothrombin group has the following factors correct answers II, VII, IX, X The fibrinogen group has the following factors correct answers I, V, VIII, XIII In serum, fibrinogen is _______________ correct answers absent In plasma, fibrinogen is _____________ correct answers present Nitric oxide functions as a: vasodilator vasoconstrictor correct answers vasodilator Fibrinogen binds to the platelet membrane, facilitating platelet: adhesion aggregation correct answers aggregation What factor is not found in serum? FI FII FVIII FXII correct answers FII What is the role of the thrombin-thrombomodulin complex: Initiate vasoconstriction Activates thrombin Inhibits factor Xa Activates protein C correct answers Activates protein C Platelets are produced from the cytoplasm of these cells Megakaryocytes Lymphoblasts Osteocytes Promonocytes correct answers Megakaryocytes
