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MMSC 423 HEMATOLOGY EXAM I, EXAM 2 AND STUDY GUIDE 20 25/2026 (ALL IN ONE DOCUMENT) EACH EXAM CONTAINS COMPLETE ACCURATE QUESTIONS AND CORRECT DETAILED ANSWERS (VERIFIED ANSWERS) A NEW UPDATED VERSIONS |GUARANTEED PASS. EXAM 1 What is a loss of viability and function associated with certain biochemical changes that are initiated when blood is stored in vitro? Answer- Storage lesion What increases in RBC storage lesion? Answer- lactic acid How does storage lesion affect the oxygen dissociation curve? Answer- Shift to the left
What are the correct ranges for temp, pulse, bp and hemoglobin/hematocrit values for blood donation? <37.5 degrees Celsius 50 - 100bpm <180/< Females >12.5g/ld. Males >13.0 g/ld. Necessary temp for blood donation <37.5 C Correct range for HR for blood donation 50 - 100 BPM
Citrating would result in this type of deferral 3 - year deferral Travel to malaria-endemic area would result in this type of deferral 12 - month deferral Immunizations of small pox, measles, mumps, yellow fever, oral polio would result in this type of deferral 2 - week deferral When the patient is positive for clinically significant antibodies, what donation product CAN be used RBC
What tests require confirmation after a positive result Haig Anti-HIV CMV Donation unit of blood for one self Autologous Type of donation in which the recipient chooses the donor Directed Given to relatives because Rh types is more similar than strangers Kills lymphocytes
The phenomenon in which some antibodies will give a different reaction strength due to the amount of antigen on the RBC dosage effect A gene that does not appear to produce a detectable antigen morph This blood group is amoprhic O This type of immunity involves: T cells B cells Antibodies Complement classical pathway
Cytokines acquired immunity What is an antibody directed against antigens that the individual does not possess? Alloantibody What is an antibody directed against one's own antigen? Autoantibody Primary response of the immune system IgM Secondary response of the immune system IgG
This is a type of antibody that requires a bridge, like the Comb’s sera for binding to the antigenic site incomplete antibody This is a type of incomplete antibody IgG What is the most immunogenic blood group antigen? D When are antibodies detectable in the patient's serum and when does a rise in antibody titer show Anamnestic response Where are antigens found RBC membrane
Where is antibody found serum/plasma What is the clumping together of RBC or any particulate matter resulting from interaction of antibody and its corresponding antigen? agglutination What is the disruption of the RBC membrane and the subsequent release of hemoglobin into the suspending medium or plasma? hemolysis ATP maintains levels of ___________, which helps maintain the shape of RBC so the cells can move throughout the bloodstream spectrum
A shift to the left results in increased/decreased pH? Increased A shift to the right results in increased/decreased DPG? increased A shift to the right results in increased/decreased temperature? Increased A shift to the right results in increased/decreased temp? Decreased This molecule controls hemoglobin affinity for oxygen 2,3 DPG
This anticoagulant functions by binding calcium Sodium citrate What does monobasic sodium phosphate buffer do? Maintains a 7 pH What does dextrose do Feeds RBC Adenine extends shelf life to __ days 35 What are ACD-A, CPR, CP2D Anticoagulants
Adenine Glucose Physical attachment of antibody in plasma to antigen on RBC Sensitization What is sensitization affected by pH temp ionic strength incubation time Physical attachment of multiple antibody-antigen complexes Lattice
What is the lattice formation affected by? characteristics of antibody molecule number of antigen sites location of antigen sites zeta potential What is the ideal pH range for agglutination? 6.5-7. What antibody reacts at the AHG phase of testing IgG What antibody is more efficient in agglutination reactions? IgM
IgG molecules bound to RBC but we cannot visualize it so we add this and that does between the formed bridges so we can visualize agglutination Will detect IgG antibody and/or C3bC3d bound to RBC polyspecific AHG reagent What does polyspecific AHG reagent contain Anti-IgG Anti-C3bC3d Test to detect globulin (antibody/complement) coating RBCs What is an antihuman globulin test? When is polyspecific reagent used DAT and IAT
What detects IgG or complement coating patient cells DAT What detects IgG or complement in patient serum IAT What test looks for in vivo antigen-antibody reaction DAT What tests look for in vitro antigen-antibody reaction IAT What test is AKA ABSC and has a crosshatch procedure IAT
