MIC 412LEC JAC: Fundamentals of Immunology (Winter 24)
Professor Amy Jacobs
University: University at Buffalo
Chapter 7 Quiz: Attempt 1- Score 100% (Highest Score)
Question 1
Which one of the following statements about primary and secondary antibody responses is NOT
true?
Question 1 options:
Antibodies in primary responses generally have lower affinity for antigen than those produced in
secondary responses.
Secondary responses reach peak levels more quickly than primary responses.
Primary responses require higher concentrations of antigen for initiation than secondary
responses.
Primary responses occur to all types of antigens, but secondary responses mostly occur only to
protein antigens.
Primary responses are characterized by IgG antibodies, whereas secondary responses are
dominated by IgM antibodies.
Answer
The statement that is NOT true is:
"Primary responses are characterized by IgG antibodies, whereas secondary responses are
dominated by IgM antibodies."
This statement is incorrect. In primary responses, the initial antibody produced is usually IgM,
and later, as the response progresses, class switching occurs, leading to the production of IgG
antibodies. In secondary responses, there is a faster and more robust production of antibodies,
with a greater proportion of IgG antibodies.
Question 2
Which one of the following statements about humoral immune responses is true?
Question 2 options:
Naive B cells are required for initiation of primary responses and memory B cells are required
for initiation of secondary responses.
Antibody responses to bacterial polysaccharide antigens require CD4+ helper T cells.
Heavy chain isotype switching typically occurs in response to bacterial polysaccharide antigens.
Affinity maturation does not require helper T cells.
