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MIC 412LEC JAC: Fundamentals of Immunology (Winter 24) Professor Amy Jacobs University: University at Buffalo Chapter 7 Quiz: Attempt 1- Score 100% (Highest Score)
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Question 1 Which one of the following statements about primary and secondary antibody responses is NOT true? Question 1 options: Antibodies in primary responses generally have lower affinity for antigen than those produced in secondary responses. Secondary responses reach peak levels more quickly than primary responses. Primary responses require higher concentrations of antigen for initiation than secondary responses. Primary responses occur to all types of antigens, but secondary responses mostly occur only to protein antigens. Primary responses are characterized by IgG antibodies, whereas secondary responses are dominated by IgM antibodies. Answer The statement that is NOT true is: "Primary responses are characterized by IgG antibodies, whereas secondary responses are dominated by IgM antibodies." This statement is incorrect. In primary responses, the initial antibody produced is usually IgM, and later, as the response progresses, class switching occurs, leading to the production of IgG antibodies. In secondary responses, there is a faster and more robust production of antibodies, with a greater proportion of IgG antibodies. Question 2 Which one of the following statements about humoral immune responses is true? Question 2 options: Naive B cells are required for initiation of primary responses and memory B cells are required for initiation of secondary responses. Antibody responses to bacterial polysaccharide antigens require CD4+ helper T cells. Heavy chain isotype switching typically occurs in response to bacterial polysaccharide antigens. Affinity maturation does not require helper T cells.
Antibody-secreting cells generated during a humoral immune response live for only a few hours. Answer The true statement about humoral immune responses is: "Naive B cells are required for initiation of primary responses and memory B cells are required for initiation of secondary responses." In primary responses, naive B cells are activated by encountering an antigen for the first time, leading to the production of antibodies. Memory B cells are then generated, and in secondary responses, these memory B cells are quickly activated upon re-exposure to the same antigen, leading to a faster and more robust antibody response. Question 3 Antibody feedback is mediated by which of the following molecules? Question 3 options: Ig FcγRIIB Ig Fcε Ig FcγRI CR IgM Answer Antibody feedback is mediated by the molecule: "Ig FcγRIIB" Ig FcγRIIB (the inhibitory Fc gamma receptor) plays a role in negative feedback regulation of the immune response. When antibodies bind to FcγRIIB, it can inhibit further activation of immune cells, helping to regulate the immune response and prevent excessive activation.
specific for the presented peptide-MHC complexes, recognize and interact with these B cells. This interaction activates the helper T cells, which, in turn, provide signals (such as cytokines) that help stimulate and support the differentiation and activation of the B cells, leading to antibody production.