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SCHOOL OF PHARMACY
VIRGINIA COMMONWEALTH UNIVERSITY
MEDC 603
Examination III Fall 2005
Dr. Desai’s Part
Name ______KEY_________________________ Pledge ____________________________
(Signature)
This section has 10 questions. Please select a letter that best matches the answer.
1. Circle the systematic name of the following steroid. (3 pts)
A: 6-methyl-9β-fluoro-11β-hydroxy-19-nor-pregn-4,6-diene-3,20-dione
B: 6-methyl-9α-fluoro-11β-hydroxy-pregn-4,6-diene-3,20-dione
C: 6-methyl-9α-fluoro-11β-hydroxy-19-nor-pregn-4,6-diene-3,20-dione
D: 6-methyl-9α-fluoro-11β-hydroxy-19-nor-androst-4,6-diene-3,20-dione
2. Draw the structure of the following steroid showing its stereochemistry and substitution pattern.
6,16β-dimethyl-estr-1,3,5,6-tetraene-3,17β-diol (3 pts)
3. A key step, targeted by statins, in cholesterol biosynthesis is (4 pts)
A: synthesis of acetyl-Coenzyme A
B: synthesis of mevalonate
C: synthesis of 3-hydroxy-3-methyl-glutaryl Coenzyme A
D: none of the above
4. Inhibition of bile re-absorption from the GI tract is the primary mechanism of (4 pts)
A: mevastatin
B: metformin
C: nicotinic acid
D: colestipol
5. Circle molecule(s) from below that are expected to possess anti-estrogenic activity (antagonist).
Please note: -2 points for every wrong answer circled. (4 pts)
OH
CH3
OH
CH3
OH
CH3
OH
OCH3
OH
OH
OH
H
CH
3
O
O
CH
3
F
OH
CH3OH
OH
CH3
CH3
