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Mechanisms of Drug Action – Course Syllabus | CHEM 416, Exams of Chemistry

Material Type: Exam; Professor: Jackson-Hayes; Class: MECHANISMS OF DRUG ACTION; Subject: Chemistry; University: Rhodes College; Term: Spring 2008;

Typology: Exams

Pre 2010

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CHEMISTRY 416, MECHANISMS OF DRUG ACTION
Spring, 2008 - TTH 9:30-10:45 A.M.
Dr. Loretta Jackson-Hayes
Office - 210 Kennedy Hall
Office hours – W, 4:00-5:00; R, 11:00-12:00
Phone - 843-3510, Email - jacksonhayesl@rhodes.edu
Text: Lange Basic and Clinical Pharmacology, 10th edition
COUSE DESCRIPTION: This course provides an introduction to Pharmacology which is the
study of chemicals that produce change in function of biological systems and the mechanisms by
which these chemicals act. We will focus on the main classes of drugs and how they affect their
target systems. We will also survey some of the more popular contemporary drugs. The course
is designed to provide students who plan to pursue medical, health professional, or biomedical
research careers a foundation for their professional or graduate coursework and research.
However, it is appropriate for any student who has an interest in the subject matter.
PREREQUISITES: Chemistry 211-211L, Chemistry 212-212L, Biology 130-131 and Biology
140-141
OBJECTIVES
During the semester you should focus on improving in the following areas:
1. Learning terminology, classifications, and methods used in the study of Pharmacology
2. Learning the names and mechanisms of action of drugs of different classes
3. Developing the ability to understand, interpret and critique scientific data
4. Learning the skills and points of view of professionals in this field
EVALUATION: During the semester, there will be three exams. The third exam, the final
exam, will be comprehensive and will cover the entire semester’s work. Quizzes will be given
each week. Each student will also give a 10 minute presentation on a “hot topic” in
Pharmacology. Topics can include but are not limited to new drugs that are on the market or
undergoing clinical trial, new experimental techniques or current research that can be used to
design new drugs. The presentations will count as one quiz grade.
The course grade will be arrived at according to the following scale:
A --- 90%,
B --- 80%,
C --- 70%,
D --- 60%,
F --- below 60%,
of the total number of points available.
Plus and minus assignments will be made within these ranges.
POLICIES: Extra credit will be awarded for attending Chemistry Departmental Seminars and
pertinent seminars sponsored by other departments. All bonus points (extra credit) will be added
to your semester point total (not the percentage) when final grades are calculated.
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CHEMISTRY 416, MECHANISMS OF DRUG ACTION

Spring, 2008 - TTH 9:30-10:45 A.M. Dr. Loretta Jackson-Hayes Office - 210 Kennedy Hall Office hours – W, 4:00-5:00; R, 11:00-12: Phone - 843-3510, Email - jacksonhayesl@rhodes.edu Text: Lange Basic and Clinical Pharmacology, 10th^ edition

COUSE DESCRIPTION: This course provides an introduction to Pharmacology which is the study of chemicals that produce change in function of biological systems and the mechanisms by which these chemicals act. We will focus on the main classes of drugs and how they affect their target systems. We will also survey some of the more popular contemporary drugs. The course is designed to provide students who plan to pursue medical, health professional, or biomedical research careers a foundation for their professional or graduate coursework and research. However, it is appropriate for any student who has an interest in the subject matter.

PREREQUISITES: Chemistry 211-211L, Chemistry 212-212L, Biology 130-131 and Biology 140-

OBJECTIVES

During the semester you should focus on improving in the following areas:

  1. Learning terminology, classifications, and methods used in the study of Pharmacology
  2. Learning the names and mechanisms of action of drugs of different classes
  3. Developing the ability to understand, interpret and critique scientific data
  4. Learning the skills and points of view of professionals in this field

EVALUATION: During the semester, there will be three exams. The third exam, the final exam, will be comprehensive and will cover the entire semester’s work. Quizzes will be given each week. Each student will also give a 10 minute presentation on a “hot topic” in Pharmacology. Topics can include but are not limited to new drugs that are on the market or undergoing clinical trial, new experimental techniques or current research that can be used to design new drugs. The presentations will count as one quiz grade. The course grade will be arrived at according to the following scale:

A --- 90%, B --- 80%, C --- 70%, D --- 60%, F --- below 60%, of the total number of points available. Plus and minus assignments will be made within these ranges.

POLICIES: Extra credit will be awarded for attending Chemistry Departmental Seminars and pertinent seminars sponsored by other departments. All bonus points (extra credit) will be added to your semester point total (not the percentage) when final grades are calculated.

I am very interested in helping you make a success of your work in this course. Therefore, office visits outside of the regularly scheduled office hours may be accommodated by appointment.

In this course you are governed by the honor code.

Your attendance at every class meeting is expected and is important to your ultimate success in the class. YOU MAY MISS TWO CLASS PERIODS DURING THE SEMESTER FOR ANY REASON. AFTER THE SECOND ABSENCE, YOUR FINAL GRADE WILL BE REDUCED BY A LETTER GRADE WITH EACH ADDITIONAL ABSENCE. A missed assignment may be made up only in the instance of an excused absence. I will determine the validity of an excuse. Quizzes may not be made up unless arrangements are made for them to be completed before the scheduled in-class time. Your lowest quiz grade will not be included when final grades are calculated. A missed quiz will count as your one quiz that will be dropped.

You are expected to complete all homework and reading assignments. Although they are not usually graded, they are essential to your success in this course. I encourage you to form study groups to complete and discuss the homework assignments.

SCHEDULE:

January 10 Introduction: general principles and definitions

  • Drug nomenclature
  • How a drug becomes available on the market

January 15 Gene based therapy

  • Survey of gene transfer technologies

January 17 Pharmacokinetics

  • Review of eukaryotic cell structure
  • Mechanisms of drug absorption and factors that influence absorption distribution
  • Routes of administration
  • Biotransformation and excretion

January 22 Pharmacodynamics ƒ Physiological receptors: structural and functional families ƒ Quantification of drug-receptor interactions ƒ Receptor regulation ƒ Actions of drugs not mediated by receptors

January 24, 29 & 31 Drug therapy of inflammation

  • Histamine, Bradykinin and their antagonists
  • Lipid-derived Autocoids: Eicosanoids and Platelet-Activating Factor
  • Analgesic-antipyretic and anti-inflammatory agents

Please mark the exam dates on your calendar and make your plans appropriately.