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Maternal Physiology-Basics of Cancer Cytogenetic-Lecture Handout, Exercises of Cancer Cytogenetics

This lecture handout was designed and distributed by Prof. Akhilesh Kulkarni at Sree Chitra Thirunal Institute of Medical Sciences and Technology. This is part of Cancer Cytogenetic course. It includes: Cardiovascular, Extrasystoles, Progesterone, Reabsorption, Malformations, Cardiac, Gastriontestinal, Genitourinary, Central, Prolactin

Typology: Exercises

2011/2012

Uploaded on 08/01/2012

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I
N SUMMARYHST 071
M
ATERNAL PHYSIOLOGIC CHANGES IN PREGNANCY
M
ATERNAL PHYSIOLOGY
C
ardiovascular System
H
eart size increases 12%
M
urmurs (systolic and diastolic)
E
CG changes similar to ischemia but due to positional changes
E
xtrasystoles, supraventricular tachycar
d
ia
O
utput rises 1.5 liters/minute
H
eart rate rises from 70 to 85 beats per minute
S
troke volume rises from 63 to 70 ml
A-V
oxygen difference drops near e nd of first tri
a
gain
B
lood pressure
S
ystolic unchanged
D
iast
o
lic drops in mid
-p
regnancy
I
ncreases again near term
P
ulse pressure higher
mester from 44 to 33 ml/l but then rises
V
enous pressure unchanged in the arms and raised in the legs
P
eripheral resistance drops
P
ulmonary pressure unchanged
C
irculation time unchanged
Figure removed due to copyright restrictions. Please see:
Elkayam, Uri, and Norbert Gleicher, eds. Cardiac Problems in Pregnancy : Diagnosis and Management of Maternal and Fetal Disease.
2nd ed. New York, NY: Liss, 1990, p. 61. ISBN: 0471505005 .
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IN SUMMARY� HST 07^1

MATERNAL PHYSIOLOGIC CHANGES IN PREGNANCY

MATERNAL PHYSIOLOGY

Cardiovascular System

  • � Heart size increases 12%
  • � Murmurs (systolic and diastolic)
  • � ECG changes similar to ischemia but due to positional changes
  • � Extrasystoles, supraventricular tachycardia
  • � Output rises 1.5 liters/minute
  • � Heart rate rises from 70 to 85 beats per minute
  • � Stroke volume rises from 63 to 70 ml
  • � A-V oxygen difference drops near end of first tri again
  • � Blood pressure
    • � Systolic unchanged
    • � Diastolic drops in mid-pregnancy
    • � Increases again near term
  • � Pulse pressure higher mester from 44 to 33 ml/l but then rises
  • � Venous pressure unchanged in the arms and raised in the legs
  • � Peripheral resistance drops
  • � Pulmonary pressure unchanged
  • � Circulation time unchanged Figure removed due to copyright restrictions. Please see: Elkayam, Uri, and Norbert Gleicher, eds. Cardiac Problems in Pregnancy : Diagnosis and Management of Maternal and Fetal Disease. 2nd ed. New York, NY: Liss, 1990, p. 61. ISBN: 0471505005.

MATERNAL PHYSIOLOGIC CHANGES IN PREGNANCY

Figure removed due to copyright restrictions.� [bar graph of Cardiac Output (L/min) vs Weeks Gestation]�

MATERNAL PHYSIOLOGIC CHANGES IN PREGNANCY

Laboratory parameter effects of pregnancy

  • � Lower hematocrit (although elevated red cell mass)
  • � Creatinine clearance rises (creatinine falls)
  • � BUN falls
  • � Plasma volume goes up
  • � Serum sodium falls
  • � Estrogen levels (all three estrogens) rise
  • � LH, FSH fall
  • � Prolactin rises
  • � TSH unchanged

FUNDAMENTAL QUESTIONS

1.�Describe the changes in cardiovascular parameters in pregnancy?

2.�What changes in pulmonary function are to be expected? Why do these

occur?

3.�Describe the changes in renal function as pregnancy progresses.

4.�What happens to serum glucose and insulin as pregnancy advances?

5.�What risks does diabetes confer on the fetus? Why?

6.�What normally happens to the hematocrit and plasma volume in pregnancy?

7.�What laboratory parameters rise and which ones fall in a normal pregnancy?

8.�What is the most optimal physiologic position for a woman to labor?

9.�Describe the changes in plasma glucose and insulin as pregnancy

advances.

10. What happens to serum binding proteins in pregnancy? Why?

MATERNAL PHYSIOLOGIC CHANGES IN PREGNANCY