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Management of Osteoporosis, Antiresorptive Agents, Posttransplant-Related Bone Loss, Strontium Ranelate, Organic Moiety, Anabolic Agents, Progestagenic Properties, Bone Turnover Markers are some points in Introduction to General Medicine lecture. This lecture is one of 61 lectures you can find here for this course.
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History of hip or vertebral fracture.
Other prior fractures and T-score between -1.0 and -2.5 at the femoral neck, total hip, or spine, as measured by dual-energy X-ray absorptiometry (DXA).
T-score -2.5 (DXA) at the femoral neck, total hip, or spine, after appropriate evaluation to exclude secondary causes.
T-score between -1.0 and -2.5 at the femoral neck, total hip, or spine and secondary causes associated with high risk of fracture, such as glucocorticoid use or total immobilization.
T-score between -1 and -2.5 at the femoral neck, total hip, or spine, and a 10-year probability of hip fracture 3 percent or a 10-year probability of any major osteoporosis-related fracture 20 percent based upon the US-adapted WHO algorithm.
12/15-lipoxygenase inhibitors: coded by the Alox15 gene which is up regulated in IL mediated bone resorption.^20
Oral calcium sensing receptor antagonists : Administration leads to a transient rise in endogenous parathyroid hormone, similar to intermittently administered exogenous parathyroid hormone 21
Sclerostin inhibitors : Sclerostin is produced by osteocytes and inhibits bone formation (^22). Antagonism of sclerostin might be associated with anabolic effects on bone. Monoclonal antibodies against sclerostin, for example, prevent its binding to Wnt coreceptors, enhancing Wnt signaling and increasing bone mass in rodents and nonhuman primates.^23
Integrin antagonists : Integrins mediate the adhesion of osteoclasts to the bone surface, an important initial step for bone resorption 24
Cathepsin-K inhibitors — Cathepsin K is a protease that may play a role in osteoclast- mediated bone resorption.^25