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Lymphatic System Structure and Function Study Guide
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Immune system protects the body against invading pathogens including bacteria, viruses, fungi, & protists. Immune system includes the lymphatic system (lymph, lymph capillaries, lymph vessel, & lymph nodes) as well as the red bone marrow & numerous leukocytes , or white blood cells. Tissue fluid enters the lymph capillaries , which combine to form lymph vessels. Skeletal muscle contractions move the lymph one way through the lymphatic system to lymphatic ducts, which dump back into the venous blood supply into the lymph nodes , which are situated along the lymph vessels, & filter the lymph of pathogens & other matter. Lymph nodes are concentrated in the neck, armpits, & groin areas. Outside the lymphatic vessel system lies the lymphatic tissue including the tonsils, adenoids, thymus, spleen, & Peyer’s patches. Tonsils – located in the pharynx, protect against pathogens entering the body through the mouth & throat. Thymus – serves as a maturation chamber for the immature T cells that are formed in the bone marrow. Spleen – cleans the blood of dead cells & pathogens. Peyer’s patches – located in the small intestines, protect the digestive system from pathogens. Body’s general immune defenses include: Skin – an intact epidermis & dermis form a formidable barrier against bacteria. Ciliated mucous membranes – cilia sweep pathogens out of the respiratory tract. Glandular secretions – secretions from exocrine glands destroy bacteria. Gastric secretions – gastric acid destroys pathogens. Normal bacterial populations – compete with pathogens in the gut & vagina.
Phagocytes & inflammation responses mobilize white blood cells & chemical reactions to stop infection. These responses include localized redness, tissue repair, & fluid seeping healing agents. Additionally, plasma proteins act as the complement system to repel bacteria & pathogens. 3 types of white blood cells form the foundation of the body’s immune system. They are: Macrophages – phagocytes that alert T cells to the presence of foreign substances. T lymphocytes – directly attack cells infected by viruses & bacteria. B lymphocytes – these cells target specific bacteria for destruction. Memory cells , suppressor T cells , & helper T cells also contribute to the body’s defense. Immune responses can be antibody-mediated when the response is to an antigen, or cell- mediated when the response is to already infected cells. These responses are controlled & measured counterattacks that recede when the foreign agents are destroyed. Once an invader has attacked the body, if it returns it is immediately recognized & a secondary immune response occurs. This secondary immune response is rapid & powerful, much more so than the original response. These memory lymphocytes circulate throughout the body for years, alert to a possible new attack.
Antigen & Typical Immune Response Antigens are substances that stimulate the immune system. Antigens are typically proteins on the surface of bacteria, viruses, & fungi. Substances such as drugs, & foreign particles can also be antigens. The human body recognizes the antigens of its own cells, but it will attack cells or substances with unfamiliar antigens. Specific antibodies are produced for each antigen that enter the body. In typical immune response, when a pathogen or foreign substances enters the body, it is engulfed by a macrophage , which presents fragments of the antigen on its surface. A helper T cell joins the macrophage, & the killer (cytotoxic) T cells & B cells are activated. Killer T cells search out & destroy cells presenting the same antigens. B cells differentiate into plasma cells & memory cells. Plasma cells – produce antibodies specific to that pathogen or foreign substance. Antibodies – bind to antigens on the surface of the pathogens & mark them for destruction by other phagocytes. Memory cells – remain in the blood stream to protect against future infections from the same pathogen.