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Chapter 26 powerpoint Material Type: Notes; Professor: Freeman; Class: Anatomy/Physiology II; Subject: BIOL Biology; University: University of Memphis; Term: Fall 2011;
Typology: Study notes
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The structure of nephrons and associated blood vessels
Structures and functions of a nephron Renal corpuscle Renal tubule and collecting duct Peritubular capillaries Urine (contains excreted substances) Blood (contains reabsorbed substances) Fluid in renal tubule Afferent arteriole Filtration from blood plasma into nephron Efferent arteriole Glomerular capsule 1 Renal corpuscle Renal tubule and collecting duct Peritubular capillaries Urine (contains excreted substances) Blood (contains reabsorbed substances) Tubular reabsorption from fluid into blood Fluid in renal tubule Afferent arteriole Filtration from blood plasma into nephron Efferent arteriole Glomerular capsule 1 2 Renal corpuscle Renal tubule and collecting duct Peritubular capillaries Urine (contains excreted substances) Blood (contains reabsorbed substances) Tubular secretion from blood into fluid Tubular reabsorption from fluid into blood Fluid in renal tubule Afferent arteriole Filtration from blood plasma into nephron Efferent arteriole Glomerular capsule 1 2 3
Pedicel of podocyte Filtration slit Fenestration (pore) of glomerular endothelial cell Basal lamina Lumen of glomerulus (b) Filtration membrane TEM 78,000x (a) Details of filtration membrane Filtration slit Pedicel Fenestration (pore) of glomerular endothelial cell: prevents filtration of blood cells but allows all components of blood plasma to pass through Podocyte of visceral layer of glomerular (Bowman’s) capsule 1 Pedicel of podocyte Filtration slit Fenestration (pore) of glomerular endothelial cell Basal lamina Lumen of glomerulus (b) Filtration membrane TEM 78,000x (a) Details of filtration membrane Filtration slit Pedicel Fenestration (pore) of glomerular endothelial cell: prevents filtration of blood cells but allows all components of blood plasma to pass through Basal lamina of glomerulus: prevents filtration of larger proteins Podocyte of visceral layer of glomerular (Bowman’s) capsule 1 2 Pedicel of podocyte Filtration slit Fenestration (pore) of glomerular endothelial cell Basal lamina Lumen of glomerulus (b) Filtration membrane TEM 78,000x (a) Details of filtration membrane Filtration slit Pedicel Fenestration (pore) of glomerular endothelial cell: prevents filtration of blood cells but allows all components of blood plasma to pass through Basal lamina of glomerulus: prevents filtration of larger proteins Slit membrane between pedicels: prevents filtration of medium-sized proteins Podocyte of visceral layer of glomerular (Bowman’s) capsule 1 2 3
= 55 mmHg 15 mmHg 30 mmHg = 10 mmHg
(GBHP) = 55 mmHg Capsular space Glomerular (Bowman's) capsule Efferent arteriole Afferent arteriole
Proximal convoluted tubule NET FILTRATION PRESSURE (NFP) =GBHP – CHP – BCOP = 55 mmHg 15 mmHg 30 mmHg = 10 mmHg
PRESSURE (CHP) = 15 mmHg
(GBHP) = 55 mmHg Capsular space Glomerular (Bowman's) capsule Efferent arteriole Afferent arteriole
Proximal convoluted tubule NET FILTRATION PRESSURE (NFP) =GBHP – CHP – BCOP = 55 mmHg 15 mmHg 30 mmHg = 10 mmHg
(BCOP) = 30 mmHg
PRESSURE (CHP) = 15 mmHg
(GBHP) = 55 mmHg Capsular space Glomerular (Bowman's) capsule Efferent arteriole Afferent arteriole
Proximal convoluted tubule
3 Mechanisms regulating GFR
Mechanisms regulating GFR