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Introduction Biochemistry - Exam 2 - Fall 2001 | 694 301, Exams of Biochemistry

Material Type: Exam; Professor: Deis; Class: 694 - INTRO BIOCHEM&MOLBIO; Subject: MOL BIO & BIOCHEM; University: Rutgers University; Term: Fall 2001;

Typology: Exams

Pre 2010

Uploaded on 09/17/2009

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Biochemistry 694:301 Name___________________________
Second Test Dr. Deis Last 5 digits of SSN _______________
Thu. Oct. 25, 2001 Row Letter ____ Seat Number ______
This exam consists of two parts. Part I is multiple choice. Each of these 25 questions is
worth two points. Answer the Part I questions on this sheet, below. Answer the Part II
questions on the question pages.
Please use BLOCK CAPITAL letters like this --- A, B, C, D, E. Not lowercase!
1. ______ 10. ______ 18. ______
2. ______ 11. ______ 19. ______
3. ______ 12. ______ 20. ______
4. ______ 13. ______ 21. ______
5. ______ 14. ______ 22. ______
6. ______ 15. ______ 23. ______
7. ______ 16. ______ 24. ______
8. ______ 17. ______ 25. ______
9. ______
GRADE:
Part I Total _______
Part II:
II-1 _______
II-2 _______
II-3 _______
II-4 _______
II-5 _______
Part II Total _______
Total, I & II _______
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Download Introduction Biochemistry - Exam 2 - Fall 2001 | 694 301 and more Exams Biochemistry in PDF only on Docsity!

Biochemistry 694:301 Name___________________________ Second Test Dr. Deis Last 5 digits of SSN _______________ Thu. Oct. 25, 2001 Row Letter ____ Seat Number ______

This exam consists of two parts. Part I is multiple choice. Each of these 25 questions is worth two points. Answer the Part I questions on this sheet, below. Answer the Part II questions on the question pages.

Please use BLOCK CAPITAL letters like this --- A, B, C, D, E. Not lowercase!

  1. ______ 10. ______ 18. ______
  2. ______ 11. ______ 19. ______
  3. ______ 12. ______ 20. ______
  4. ______ 13. ______ 21. ______
  5. ______ 14. ______ 22. ______
  6. ______ 15. ______ 23. ______
  7. ______ 16. ______ 24. ______
  8. ______ 17. ______ 25. ______

GRADE:

Part I Total _______

Part II:

II-1 _______ II-2 _______ II-3 _______ II-4 _______ II-5 _______

Part II Total _______

Total, I & II _______

  1. The difference between a Cerebroside and a Ganglioside is that A. one is a sphingolipid, the other a phosphatidyl lipid B. one contains a fatty acid amide, the other a fatty ester C. one contains a sugar head group, the other an oligosaccharide D. one has sugar phosphate, the other simply a sugar
  2. Eucaryotic cell membranes are strengthened by A. the cell wall D. polyunsaturated fats B. glycolipids E. all of the above C. proteins like Spectrin
  3. Cardiolipin is found in A. the mitochondrial inner membrane D. the lysosome B. the nuclear membrane E. the endoplasmic reticulum C. the eucaryotic cell membrane
  4. Primary Active Transport – fueled by (what) to transport (what)? A. sugars, sugars D. GDP, proteins B. ATP, ions E. none of the above C. cAMP, amino acids
  5. The Acetylcholine Receptor is composed of how many subunits? A. 1 D. 6 B. 4 E. 8 C. 5
  6. Potassium can not pass through the voltage gated Sodium Channel because A. inactivation prevents it D. K+^ is too large B. too much Sodium gets in way E. none of the above C. K+^ is too positive
  7. Protein Kinase C transfers a phosphate to Serine in substrate proteins containing the sequence RKGSLRQ. Like Protein Kinase A, PKC has a regulatory domain with a pseudosubstrate sequence. Which of the following would be a good candidate for this sequence? A. RAGSLRQ D. RKGSARQ B RKASLRQ E. RKGSLAQ C. RKGALRQ
  8. An inhibitor of the enzyme Acetylcholinesterase could be used as A. a sleeping pill D. antibiotic B. inhibitor of gastric acidity E. nerve gas C. anti-inflammatory
  1. You drink a glass of milk. An hour later you have intestinal cramps and other gut symptoms. Chances are you have A. galactosemia C. lactose intolerance B. diabetes D. malaria
  2. Glucose which has been oxidized to have a carboxyl group at C-6 is called: A. Gluconate D. Fructose B. Glucuronate E. Sedoheptulose C. Glucarate
  3. D-Xylulose forms a glycoside when a substituent is added to which position? A. 1 D. 4 B. 2 E. 5 C. 3

20.* Interpret the "chair" structure shown below. What is the name of the sugar represented? A. alpha-D-Mannose D. beta-D-Allose B. alpha-D-Glucose E. beta-D-Ribose C. alpha-D-Galactose

  1. When insulin signals ingestion of food, GLUT-4 receptors are A. rapidly synthesized D. translocated to outer membrane B. rapidly destroyed E. blocked by binding insulin C. put into inactive mode
  2. Aldolase forms a covalent connection between substrate and a residue of A. lysine D. glutamate B. serine E. alanine C. cysteine
  3. The normal mechanism of G3PDH is directly disrupted by A. cyanide D. citrate B. 2, 4 DNP E. arsenate C. Fru-2,6 BP

24.* The graph below represents the kinetics of PFK-I when F6P is held constant and ATP is varied. The lines marked "+" show the kinetics in the presence of what? A. cyclic AMP D. Glucose 6 P B. Calcium ion E. Fru-2,6-BP C. 2,3 BPG

  1. How many points is this question worth? A. 0 C. 2 B. 1 D. I don't know

PART II Answer these questions here on the question pages.

  1. a. Draw Phosphatidyl Serine, and show how it would be cleaved by Phospholipase C.

(3)

b. Draw a sketch which illustrates the Fluid Mosaic Model of membrane structure.

(2)

c. Where is Acetylcholinesterase located? Why is it such a fast acting enzyme? Be as specific as you can.

(3)

d. Briefly describe the process for an Excised Patch Mode Patch-Clamp Conductance experiment. What would one be trying to observe by doing this?

(2)

  1. a. Sketch the structure of IgG – show the chains and label the constant and variable regions within each chain.

(3)

b. What genes are involved in generation of antibody diversity? Diagram the germ-line DNA as done in class and in the text. Label the gene segments and tell what the abbreviations stand for.

(3)

c. Distinguish functionally between Class I and Class II MCH proteins. For a complete answer you have to discuss various T-cells, etc.

(4)

4.* a. What cofactors are represented below?

(4)

b. Draw the disaccharide D-mannopyranosyl α1-4 β D-xylulofuranose in the Haworth projection. For partial credit just draw D-Mannose and D-Xylulose in the Fischer projection.

(4)

c. Draw the alpha and beta anomers of D-Fructopyranose (2)