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Adrenergic drug study guide, covers nomenclature, uses, mode of action, side effects, and contraindications
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Drug Classification Main Effect Drugs Clinical Indications Additional Info Adverse Effects Sympathomimetics (agonists) -adrenergicadrenergic (-adrenergic1 receptors) -adrenergic1: smooth muscle contraction(vasoconstriction) increased BP -2: negative feedback to decrease release of NE
metaraminol, phenylephrine Raise BP in hypotensive states, nasal/eye decongestant NE prototype IV admin/short acting GI/urinary inhibition IV (skin infiltration) Hypertensive crisis, cerebral hemorrhage, cardiac arrhythmias, nasal/eye dryness Nonselective -adrenergic1 & -adrenergic adrenergic -adrenergic1: cardiac stimulation; increased HR, force of contraction -adrenergic2: smooth muscle relaxation; bronchodilation, uterine, increased blood flow to heart/skeletal muscle Dopamine, Ephedrine, Isoproterenol EPI ( & ) Circulatory shock bronchodilator, anaphylaxis Cardiac arrest, asthma, vasoconstriction (surgery) Restlessness, tremors, anxiety Older -adrenergic cardiac arrhythmias -adrenergic2: lower BP, at high dosages-adrenergic overstim. of heart (-adrenergic1) Selective -adrenergic adrenergic see above (-adrenergic2) Albuterol, formoterol, salmeterol, terbutaline Bronchodilator Sympatholytics (antagonists) -adrenergic1 adrenergic blockers Smooth muscle relaxation (vasodilation), decreased BP Doxazosin, prazosin, tamsulosin, terazosin Hypertension, prostatic hyperplasia, Raynaud’s disease Raynaud’s disease Compensatory reflex tachycardia, orthostatic hypotension, fainting Nonselective -adrenergic1 & -adrenergic adrenergic blockers -adrenergic1: decreased HR, force of contraction -adrenergic2 smooth muscle contract(NT) Nadolol, pindolol, propranolol, timolol Chronic heart failure, hypertension, angina pectoralis Nausea, diarrhea Bradycardia, congestive heart failure, cardiac arrest Drowsiness, CNS disturbances Selective -adrenergic1 adrenergic blockers -adrenergic1: decreased HR, force of contraction Atenolol, acebutolol, esmolol, metoprolol Hypertension, tachycardia, cardiac arrhythmias, angina pectoralis Adrenergic neuronal blockers Decrease sympathetic activity, lowers BP & cardiac function Methyldopa