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A chemistry homework assignment focused on enzyme inhibition and regulation. It includes multiple-choice questions about competitive, noncompetitive, and uncompetitive inhibitors, as well as questions about the structures of sulfanilamide and para-aminobenzoic acid, and the mechanism of aspirin's inhibition of cyclooxygenase-2. The assignment also includes a question about generating a lineweaver-burk plot for an enzyme-catalyzed hydrolysis reaction. Lastly, there is a question about a biosynthetic pathway and the regulation of its enzymes by their products.
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Chemistry 4202 Name
Homework 3 20 points
enzyme cyclooxygenase-2 (Cox-2, also known as PGH 2 synthase), which is involved in the synthesis of prostaglandins, mediators of inflammation, pain, and fever. Research the mechanism of inhibition and answer the following questions. (a) Briefly explain the mechanism of inhibition. What type of inhibition is it? (b) Aspirin can also inhibit a related intestinal enzyme cyclooxygenase-1 (Cox-1). What side effects can result from the inhibition of this enzyme? Why?
Chemistry 4202 Name
Homework 3 20 points (a) Generate a Lineweaver-Burk plot for the data. (b) What type in inhibition is being measured?