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Information on Lanoxin Solution for Injection, including its uses, warnings before use, instructions for use, and storage. It also lists medications that may interact with Lanoxin and their effects. It is essential for healthcare professionals and patients to understand this information to ensure safe and effective use of Lanoxin.
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Lanoxin 500 micrograms/2ml Solution for Injection (Digoxin) Read all of this leaflet carefully before you start using this medicine because it contains important information for you.
3. How to use Lanoxin Solution for Injection This medicine is available as an injectable solution for intravenous administration. Always use this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Your doctor will have decided how much of this medicine is right for you: - It depends on what heart problem you have and how serious it is - It also depends on your age, weight and how well your kidneys work - While you are taking this medicine, your doctor will take regular blood tests. This is to determine how you are responding to treatment. - Your doctor will adjust your dose based on your blood test results and on how you are responding to treatment. This is why you must strictly adhere to the treatment course prescribed your doctor.
Uncommon (may affect up to 1 in 100 people)
Marketing Authorisation Holder Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland Tel: +353 1 6308400 Manufacturer GlaxoSmithKline Manufacturing S.p.A, Strada Provinciale Asolana 90, 43056 San Polo di Torrile, Parma, Italy Cenexi – Fontenay Sous Bois, 52 rue Marcel et Jacques Gaucher, Fontenay-Sous Bois, 94120, France This leaflet was last revised in 03/ The following information is intended for healthcare professionals only. Handling Instructions Dilution of Lanoxin Lanoxin Solution for Injection can be administered undiluted or diluted with a 4-fold or greater volume of 0.9% Sodium Chloride Injection, 0.18 % Sodium Chloride/4% Glucose Injection or 5% Glucose Injection. A 4-fold volume of diluent equates to adding one 2 ml ampoule of digoxin to 6 ml of injection solution. The use of less than a 4-fold volume of diluent could lead to precipitation of digoxin. Lanoxin Solution for Injection, when diluted in the ratio of 1 to 250 is known to be compatible with the following infusion solutions; Sodium Chloride I.V. Infusion, B.P., 0.9 % w/v. Sodium Chloride (0.18 % w/v) and Glucose (4 % w/v) I.V. Infusion, B.P. Glucose I.V. Infusion, B.P., 5 % w/v. A ratio of 1 to 250 can be obtained for example by diluting one 2 ml ampoule with 500 ml of infusion solution. Dilution should be carried out either under full aseptic conditions immediately before use. Any unused solution should be discarded Administration of Lanoxin injection: Each dose should be given by I.V. infusion over 10 to 20 mins. The total loading dose should be administered in divided doses with approximately half of the total dose given as the first dose and further fractions of the total dose given at intervals of four to eight hours. An assessment of clinical response should be performed before giving each additional dose. The I.M. route is painful and is associated with muscle necrosis. This route cannot be recommended. Rapid I.V. injection can cause vasoconstriction producing hypertension and/or reduced coronary flow. A slow injection rate is therefore important in hypertensive heart failure and acute myocardial infarction.