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Immune response to cancer, Summaries of Pathology

A short ppt form of notes of topic immune response to cancer

Typology: Summaries

2022/2023

Uploaded on 07/04/2025

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Immune Response and Reaction
on Cancer
Presented by: [Your Name]
Department of Pathology
MBBS 2nd Year
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Immune Response and Reaction

on Cancer

Presented by: [Your Name] Department of Pathology MBBS 2nd Year

Introduction

  • (^) - Cancer arises due to uncontrolled proliferation of abnormal cells.
  • (^) - The immune system plays a crucial role in:
  • (^) • Immunosurveillance
  • (^) • Immunoediting
  • (^) • Modulating tumor microenvironment

Innate Immune Response

  • (^) - NK Cells: target cells with low MHC I, use perforins and granzymes
  • (^) - Macrophages (M1): activated by IFN-γ, release ROS and TNF-α

Adaptive Immune Response

  • (^) - CD8+ CTLs: recognize MHC I-bound tumor antigens
  • (^) - CD4+ T cells: activate CTLs and macrophages
  • (^) - B cells: antibody production, ADCC, complement activation

Immunoediting

  • (^) - Elimination: immune destruction of tumor
  • (^) - Equilibrium: dormancy phase
  • (^) - Escape: immune-resistant tumor proliferation

Immunotherapy Approaches

  • (^) - Checkpoint inhibitors: Anti-PD-1, CTLA-
  • (^) - CAR T-cell therapy: B-cell ALL
  • (^) - Cancer vaccines: HPV, HBV
  • (^) - Monoclonal antibodies: Trastuzumab, Rituximab

Summary

  • (^) - Immunity plays dual roles in cancer
  • (^) - Evasion and immunoediting aid tumor survival
  • (^) - Immunotherapies are revolutionizing treatment
  • (^) - Ongoing research is critical

References

  • (^) 1. Robbins Basic Pathology, 10th ed.
  • (^) 2. Harsh Mohan Pathology, 8th ed.
  • (^) 3. Ramdas Nayak Manual of Pathology