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Immune response overview diagram, Schemes and Mind Maps of Immunology

Trinity CollegeImmunology

Typology: Schemes and Mind Maps

2020/2021

Uploaded on 06/11/2021

johnatan
johnatan 🇺🇸

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bg1
innate immunity
0-4hrs
inflammation
4-96hrs
MBL
CH
�►-Q-complement activation -Q-
inflammatory response (C3a, C4a, CSa)
opsonisation of pathogens (C3b, C4b)
MAC complex pathogen lysis (C5b-C9)
TLR
I
I
I
I
I
I
I
I
I
I
MHC Il
PAMP PRR
NF-KB activation ii costimulatory
molecules e.g. B7
proinflammatory cytokine release
IL-1 IL-6 IL-8 IL-12 TNFa
ii CRP
fever
m1cro-
coagulation
to prevent
spread of
infection
increased
capillary
permeability
➔oedema and
swelling
chemotaxis
utrophil
B7
I
I
I
I
I
I
I
I
I
I
I
I
MHC
MHC Il
!*@!
4-IBBL
B7
infected
I cell
synapse formation (cells touch)
perforin, granzymes, granulysin
):� induction of apoptosis )�
p
CD40 IFN-y
cell-mediated
immunity
TH1
----------·
TCR
CD40
+++
MHC Il humoral
immunity
TH2
I L-2 IL-4 I L-5
A y
-<
-
neutralise toxins
opsonise pathogens
.,.-antibodies � -< "- 1"""' activate complement
lgM ➔ lgG lgA lgE � A activate effector cells

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innate immunity

0-4hrs

inflammation

4-96hrs

MBL CH

�►^ -Q-^ complement activation^ -Q-

inflammatory response (C3a, C4a, CSa) opsonisation of pathogens (C3b, C4b) MAC complex pathogen lysis (C5b-C9)

TLR

I I I I I I I I I I

MHC Il

PAMP PRR

NF-KB activation ii costimulatory

molecules e.g. B

proinflammatory cytokine release

IL-1 IL-6 IL-8 IL-12 TNFa

ii CRP

fever

m1cro-

coagulation

to prevent

spread of

infection

increased

capillary

permeability

➔ oedema and

swelling

chemotaxis

utrophil

B

I I I I I I I I I I I

MHC

MHC Il

B7^ 4-IBBL

infected

I cell

synapse formation (cells touch) perforin, granzymes, granulysin ):� induction of apoptosis )�

p

CD IFN-y

cell-mediated

immunity

TH^1

TCR

CD

MHC Il humoral

immunity

TH 2

IL-2 IL-4 I L-

A (^) -<y

neutralise toxins opsonise pathogens .,.- antibodies � -< "- 1 """' activate complement lgM ➔ lgG lgA lgE � A activate effector cells