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Selecting Appropriate Pharmaceutical Excipients: Compatibility and Quality Considerations, Study Guides, Projects, Research of Medicine

Guidelines for selecting appropriate pharmaceutical excipients for specific drug formulations. It discusses the importance of excipient compatibility with the main drug and the impact of excipient physical and chemical properties on the preparation quality. The document also mentions the role of cd formulation as a reliable source for excipients and related services.

What you will learn

  • How can compatibility studies be conducted to ensure the selection of compatible excipients?
  • What is the role of CD Formulation in the pharmaceutical industry and what services does it offer?
  • What factors should be considered when selecting pharmaceutical excipients for a specific drug formulation?

Typology: Study Guides, Projects, Research

2020/2021

Uploaded on 05/06/2022

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How to Select Pharmaceutical Excipients?
Pharmaceutical excipients refer to the substances used in the production and
formulation of medicines. They perform multiple functions in pharmaceutical
preparations and are likely to affect the quality, safety and effectiveness of drugs.
Pharmaceutical excipients can be classified into natural, semi-synthetic and fully
synthetic compounds according to their sources. And based on their use, excipients
can be divided into diluents, binders, disintegrants, lubricants, glidants and
anti-caking agents, wetting agents and solubilizers.
Among all varieties of excipients, how to select the most appropriate ones for a
specific drug formulation project? The guidelines below should be taken into
consideration.
The compatibility of the main drug and the excipients should be studied.
When screening and researching drugs with new chemical structures, attention
should be paid to the investigation of the interaction between the main drug and the
excipients. The excipients should have stable properties with no physiological activity,
no influence on the content determination of the main drug and no adverse effect on
the dissolution and absorption of the drug. According to the above principles, when
we select excipients, we must first conduct research on the compatibility of the main
drug and excipients. Through preliminary investigation, we can understand the
excipient-to-excipient interaction and excipient-to-drug interaction, to avoid the
selection of excipients with adverse interactions in prescription design.
For lack of relevant research data, compatibility studies can be conducted. For
example, for solid oral preparations, several kinds of excipients can be selected at
first, and then mix the main drug and excipients with a certain proportion, and put
them under strong light (4500±500Lux), high temperature (60) and high humidity
(90±5 %) conditions for 10 days, and finally use HPLC to check whether the content
and related substances changed before and after placing. When necessary, the active
pharmaceutical ingredients (APIs) and excipients can be used for parallel control
experiments to judge whether it is the change of the API itself or the influence of the
excipients. If conditions permit, experiments such as hot plate (DTA or DSC) can be
used to determine whether the main drug interacts with the excipients.
The selection of excipients should be quality centric.
The choice of excipients should first consider the mechanism of action of the drug.
Second, the excipients chosen should meet the characteristics and requirements of
the dosage form. Third, it is a must to study the effect of the excipient’s physical and
chemical properties on the preparation. Changes in the excipient’s physical and
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How to Select Pharmaceutical Excipients?

Pharmaceutical excipients refer to the substances used in the production and formulation of medicines. They perform multiple functions in pharmaceutical preparations and are likely to affect the quality, safety and effectiveness of drugs. Pharmaceutical excipients can be classified into natural, semi-synthetic and fully synthetic compounds according to their sources. And based on their use, excipients can be divided into diluents, binders, disintegrants, lubricants, glidants and anti-caking agents, wetting agents and solubilizers. Among all varieties of excipients, how to select the most appropriate ones for a specific drug formulation project? The guidelines below should be taken into consideration. The compatibility of the main drug and the excipients should be studied. When screening and researching drugs with new chemical structures, attention should be paid to the investigation of the interaction between the main drug and the excipients. The excipients should have stable properties with no physiological activity, no influence on the content determination of the main drug and no adverse effect on the dissolution and absorption of the drug. According to the above principles, when we select excipients, we must first conduct research on the compatibility of the main drug and excipients. Through preliminary investigation, we can understand the excipient-to-excipient interaction and excipient-to-drug interaction, to avoid the selection of excipients with adverse interactions in prescription design. For lack of relevant research data, compatibility studies can be conducted. For example, for solid oral preparations, several kinds of excipients can be selected at first, and then mix the main drug and excipients with a certain proportion, and put them under strong light (4500±500Lux), high temperature (60℃) and high humidity (90± 5 %) conditions for 10 days, and finally use HPLC to check whether the content and related substances changed before and after placing. When necessary, the active pharmaceutical ingredients (APIs) and excipients can be used for parallel control experiments to judge whether it is the change of the API itself or the influence of the excipients. If conditions permit, experiments such as hot plate (DTA or DSC) can be used to determine whether the main drug interacts with the excipients. The selection of excipients should be quality centric. The choice of excipients should first consider the mechanism of action of the drug. Second, the excipients chosen should meet the characteristics and requirements of the dosage form. Third, it is a must to study the effect of the excipient’s physical and chemical properties on the preparation. Changes in the excipient’s physical and

chemical properties may affect the quality of the preparation in terms of viscosity, particle size and distribution, fluidity, moisture, pH, etc. For the polymer materials used in sustained and controlled release formulations, changes in molecular weight and viscosity may have a significant impact on the release behavior of drugs. Therefore, according to the characteristics of the preparation and the route of administration of the drug, the physicochemical properties of the excipients in the prescription that may affect the quality of the preparation should be analyzed. If necessary, the corresponding quality control standards should be formulated, and attention should be paid to the selection of appropriate sources of supply to ensure the stability of the quality of excipients. It should be noted that although some excipients pass the short-term compatibility test without problems, new degradation impurities may appear after 3-6 months of accelerated test. On the contrary, sometimes the compatibility study is first problematic, everything gets fine after adjusting the ratio. For instance, captopril (captopril) and magnesium stearate are incompatible, but the tablet with high drug content (100mg) and magnesium stearate are stable, while tablets with low drug content (2 mg) showed significant incompatibility. Therefore, the results of the compatibility test between raw materials and excipients cannot fully represent the stability under real conditions. CD Formulation is a leading manufacturer of a large variety of excipients. Driven by the latest science and technology, it has grown to be a reliable source for the pharmaceutical industry, offering not only rich collection excipients but also a wide range of preformulation, formulation, analytical and custom pharmaceutical excipients services. Always at the forefront of innovation, CD Formulation aims to address the challenges arising from pharmaceutical formulation, and in a much broader sense, hopes to advance the global medical business.