Hot Melt Extrusion Excipients
Hot melt extrusion is the process by which the bulk drug is dispersed at the
molecular level of the matrix to form a solid solution, thus facilitating the
development of low solubility products. Hot melt extruding agent helps dissolve,
bond, stabilize and control release. We have professional production equipment
and management experience, can customize different specifications and quality
requirements of hot melt extrusion, and produce the corresponding products
according to customers' prescriptions.
Process Flow of Hot Melt Extrusion
Hot melt extrusion process, the API and the carrier, and a variety of
complementary makings after joining extruder, in under the action of
mechanical force, tank heating, first of all, the material melt, then scattered
mixed make active pharmaceutical ingredient and various auxiliary materials
evenly dispersed in carrier, small molecules will be further degradation and
remove moisture from the material, in the end by the extruder screw extrusion
materials from the nose. After the material is extruded from the extruder, it can
be cooled in a variety of ways. Finally, crush, cut or rewind as required.
Application of Hot Melt Extrusion in the Field of Pharmaceuticals
Improve Drug Solubility and Bioavailability
The biopharmaceutical classification system (BCS) classifies drugs into 4
categories based on their solubility in water and permeability in the intestines.
The solubility of category II and category IV drugs is poor, and 40% of the drugs
are currently on sale. 80% to 90% of the drugs under research are classified
into categories II and IV, so the improvement of the solubility of such drugs is of
great significance for improving their absorption. At the same time, the BCS II
and IV APIs that are in the development stage will continue to grow, as shown
in the figure below.
