Major Organic Products of Given Reactions, Study notes of Organic Chemistry

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Give the major organic product(s) of

the following reaction.

2016-09-26 Q

1) CH 3 CH 2 MgBr

2) H 3 O+

E. There is no

reaction or the

correct product

is not listed

here.

A

B

C D

Explanation

2) H+

1) CH 3 CH 2 MgBr

2) H 3 O+

CH 3 CH 2 MgBr

Exam 2

• Time:
  • Tuesday, October 18: 7:00 – 9:00PM OR
  • Wednesday, October 19: 7:00 – 9:00PM OR
  • Thursday, October 20: 7:00 – 10:00PM
• Location – Soc/Anthro Testing Center
  • Chapters will be covered in this order: Chapter 19, 12
• Practice Exams are Posted
  • Ex2-14-98 Practice Exam 2A
  • Ex2-14-98 Practice Exam 2B

• Deadline for alternate arrangements is Monday,

10/17/2016 at 4:30 PM (i.e., close of business)

• An oral make-up exam will be required for making up the exam for all students not taking the exam on the above dates or having already made prior arrangements

No Class Wednesday!

My wife is having a procedure done

at the hospital and I need to be at

the hospital.

Order of Coverage (Exam 2)

Homework Assignment Due Date

13 Ex2-07-B7-12-03A Carbox Acid Rxns Thursday, October 6, 2016

14 Ex2-07-B7-12-03B Carbox Acid Rxns Friday, October 7, 2016

15 Ex2-08-B7-12-04A Naming Carbox Acid Derivatives

Saturday, October 8, 2016

16 Ex2-08-B7-12-04B Naming Carbox Acid Derivatives

Sunday, October 9, 2016

17 Ex2-09-B7-12-05A Rxns Acid Chlorides Monday, October 10, 2016

18 Ex2-09-B7-12-05B Rxns Acid Chlorides Tuesday, October 11, 2016

19 Ex2-10-B7-12-06A Rxns Esters Wednesday, October 12, 2016

20 Ex2-10-B7-12-06B Rxns Esters Thursday, October 13, 2016

21 Ex2-11-B7-12-07A Rxns Amides Friday, October 14, 2016

22 Ex2-11-B7-12-07B Rxns Amides Saturday, October 15, 2016

23 Ex2-12-B7-12-08A Step Growth Polymers Sunday, October 16, 2016

Exam 2 October 18, 19, 20

Appealing Computer Grading

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email. When we determine final letter grades at

the end of the semester and if you are one or two

questions short of your preferred letter grade, we

will look at appeals at that point in time.

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Grignard Reactions with Epoxides

CH 3 CH 2 MgBr

CH 3 CH 2 MgBr

Preferred: 1 o^ vs 2o

Analogous to SN2 Reactions: Steric Effects Rule!

Give the major organic product(s) of

the following reaction.

**1) CH 3 CH 2 MgBr

2. H 3 O+**

E. There is no reaction or the correct product is not listed here.

A B

C D

2016-09-26 Q

Hydride Reductions

NaBH 4

• Weaker Hydride
• Reacts with
  • Aldehydes and Ketones
• Does Not React with
  • Esters
  • Carboxylic Acids (????)
  • Amides

LiAlH 4

• Stronger Hydride
• Reacts with
  • Aldehydes and Ketones
  • Esters
  • Carboxylic Acids
  • Amides
    • Acid Work-up
    • Basic Work-up

Mechanism of Hydride Reduction:

Aldehydes and Ketones

1) LiAlH 4

2) H 3 O+

H+

H+

1) LiAlH 4

2) H 3 O+

1) NaBH 4

2) H 3 O+

H 2

H 2

Hydrides with Carboxylic Acids

Same as starting materials, but there has been a reaction!

The carboxylic acid has been reduced to the alcohol!

Amide Reduction by LiAlH

Acidic Work-up

Basic Work-up

1) LiAlH 4

2) H 3 O+

H+

NaOH