M DeVries-Rizzo, BScN, MScN, RN(EC) Nurse Practitioner, Paediatric Neurology, Children’s Hospital, LHSC
Disclaimer: The contents are for informational purposes only. The content is not intended to be a substitute for professio nal
medical advice, diagnosis, or treatment. Always see k the advice of your health care provider with any questions that you
may have regarding this medication.
Generic Name: ValproicAcid or Divalproex Sodium
Brand Name: Epival Depakene
What Is It Used For?
Decreasing seizure activity in various types of seizures; a broad spectrum
anticonvulsant.
May be given intravenously in the emergency department for status epilepticus.
How Long Does The Oral Medicine Take To Work?
2-5 days
What Are The Important Safety Concerns?
When first starting the medicine, your child may be slightly drowsy and/or dizzy.
Only adjust the dosage as recommended by your health care provider. They will
usually increase this medication slowly to avoid side effects. Never increase the
dosage more than once per week unless directed otherwise.
Once you have started with one brand of the medication stay with it. Avoid
switching between different brands.
Check with your pharmacist before taking herbal medications and/or over-the-
counter medications. They may have adverse effects if taken with anti-seizure
medications.
Do not stop taking this medication suddenly because this could result in seizures.
Does My Child Need Bloodwork With This Medication?
A blood test may be done before starting this medication to check your child’s liver
function and blood counts. If the blood tests are normal, it is very safe for your
child to take this medication.
Routine blood work may be done to help determine the best dosage for
your child, and also if they have side effects to the medication.
If your child is required to have blood work it must be done BEFORE they get their
medication. This is called a trough level. This level usually falls between 350 and
700.
What Are The Possible Side Effects?
Abdominal Pain*
Nausea & Vomiting*
Tremors
Constipation*
Rash*
Unsteadiness
Increased Appetite*
Weight Gain*
Hair Loss
Diarrhea*
Headache*
Liver Problems
Dizziness*
Heartburn*
Increased Bruising
Double Vision*
Drowsiness*
Irregular Periods
* more common side effects
