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These notes provide information on thymoquinone, a p-benzoquinone compound extracted as a volatile oil, and its potential use as an anti-cancer agent. Topics covered include epithelial-mesenchymal transition (emt), acetaminophen-induced hepatotoxicity, hormone receptors, angiogenesis, mirna expression, and the p53 signaling pathway.
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Notes Inhibiting or triggering apoptosis on the cancer cell proliferation. It is extracted as a volatile oil. Belongs to a class of organic compounds known as p-benzoquinones. It has gained a fair deal of attention regarding to be used as a potential anti-cancer agent. Epithelial-mesenchymal transition (EMT) is a complex developmental program that enables carcinoma cells to suppress their epithelial features changing to mesenchymal ones. This change allows cells to acquire mobility and the capacity to migrate from the primary site. What is acetaminophen-induced hepatotoxicity? Find the uses? Types that are present beside this? Carcinoma: type of cancer starts in cells that make up the skin or tissue lining organs [ arises in epithelial tissue of the skin or lining of the internal organs] Which part of the hormone recognizes the chemical compound to bond? angiogenesis Same structure to bond (competitive inhibitor) Estrogen hormones, androgen hormones (receptors) Can thymoquinone work as hormonal disruptors (endocrine disruptors)? Treating drugs to alkylating agents Telomeric attrition: miR-34a expression is increased by p35 while down-regulating Rac1 expression. Leads to actin depolymerization and interrupting actin cytoskeleton. Depolymerization of the actin cytoskeleton leads to reduction in lamellipodia and filopodia formation, thus, resulting in disruption of cell migration. Immunomodulatory agent: is a substance that suppresses or stimulates the immune system for the body to fight against cancer and other diseases. Which miRNA changes their expression with treatment Sequencing with TQ can useful to analyse the treatment Chip micro arrays- p53 signaling pathway: one of the tumor suppressor genes in charge of various cellular mechanisms, which includes apoptosis, cell cycle progression, cell death, cell proliferation inhibitors. Significant function of p53 is the transcription trait as either an activator or repressor,