Notes
Inhibiting or triggering apoptosis on the cancer cell proliferation. It is extracted as a volatile oil. Belongs
to a class of organic compounds known as p-benzoquinones. It has gained a fair deal of attention
regarding to be used as a potential anti-cancer agent.
Epithelial-mesenchymal transition (EMT) is a complex developmental program that enables carcinoma
cells to suppress their epithelial features changing to mesenchymal ones. This change allows cells to
acquire mobility and the capacity to migrate from the primary site.
What is acetaminophen-induced hepatotoxicity? Find the uses? Types that are present beside this?
Carcinoma: type of cancer starts in cells that make up the skin or tissue lining organs [ arises in epithelial
tissue of the skin or lining of the internal organs]
Which part of the hormone recognizes the chemical compound to bond?
angiogenesis
Same structure to bond (competitive inhibitor)
Estrogen hormones, androgen hormones (receptors)
Can thymoquinone work as hormonal disruptors (endocrine disruptors)?
Treating drugs to alkylating agents
Telomeric attrition:
miR-34a expression is increased by p35 while down-regulating Rac1 expression. Leads to actin
depolymerization and interrupting actin cytoskeleton.
Depolymerization of the actin cytoskeleton leads to reduction in lamellipodia and filopodia formation,
thus, resulting in disruption of cell migration.
Immunomodulatory agent: is a substance that suppresses or stimulates the immune system for the body
to fight against cancer and other diseases.
Which miRNA changes their expression with treatment
Sequencing with TQ can useful to analyse the treatment
Chip micro arrays-
p53 signaling pathway: one of the tumor suppressor genes in charge of various cellular mechanisms,
which includes apoptosis, cell cycle progression, cell death, cell proliferation inhibitors. Significant
function of p53 is the transcription trait as either an activator or repressor,
