Fucoidan and it's benefits as a placebo, Study Guides, Projects, Research of Biotechnology

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FUCOIDAN AND

IMMUNE RESPONSE

06/04/

U N I V E R S I T Y O F A G R I C U L T U R E A N D F O R E S T R Y H O C H I M I N H C I T Y F a c u l t y o f B i o l o g i c a l S c i e n c e s

Group 3 Presenter: Pham Nguyen Bao Nhi

2

MEMBER

Phạm Nguyễn Bảo Nhi - Phạm Thị Ngọc Huyền - 21126 Võ Hoàng Minh - 21126 Nguyễn Trọng Khôi - 21126 Dương Tuấn Kiệt - 21126 Nguyễn Thị Thu Ngân - 2112645

GROUP 3

CONTENTS

1. Fucoidan

2. Fucoidan and response

2.1 Immunological Effect of Fucoidan on Macrophages

2.2 Immunological Effect of Fucoidan on NK Cells

2.3 Immunological Effect of Fucoidans on T Cells

3. Conclusion

4

Benefits of Fucoidan

4

FUCOIDAN

AND

IMMUNE

RESPONSE

5

• The immune system comprises immune organs,cells, and immune-reactive substances
• Immunoregulatory action fucoidan is the key mechanism to protect the cells via activation of host immune responses
• Fucoidan possess a wide range of immunomodulation effects through stimulating of Macrophages, Natural killer (NK) cells, dendritic cells (DCs) and T cells activities Effects of Fucoidans on the Immune System

Natural Killer cell Function of Natural Killer cell:

• Klling virally infected cells
• Detecting and controlling early signs of cancer

Natural Killer cell^ indentify Abnormal cell (no presence MHC)

destroy secrete chemicals

Function of Natural Killer cell

2. 2. Immunological Effect of Fucoidan on NK cell

Immunological Effect of Fucoidan on Macrophages

• Fucoidan from Fucus vesiculosus and Undaria pinnatifida could significantly increase NK cells proliferation
• Fucoidan from other sources (Fucus vesiculosus, Undaria pinnatifida, Ascophyllum nodosum, Macrocystis pyrifera) could activate NK cells via increasing killer cell lectin-like receptor and IFN-γ

Fucus vesiculosus

Undaria pinnatifida

Fucus vesiculosus (^) Undaria pinnatifida

Ascophyllum nodosum Macrocystis pyrifera

3. Conclusion

Fucoidans have a range of immunomodulatory effects by acting through DCs, macrophages, NK cells, T cells, and B cells Despite many beneficial effects and promising future prospects for fucoidan, one of the challenges is the standardization of fucoidan, since not all fucoidans are equal in their pharmacological effects (structure, molecular weight, chemical composition, and bioactivity of fucoidans differ from species to species, the extraction method)

1. Apostolova, E., Lukova, P., Baldzhieva, A., Katsarov, P., Nikolova, M., Iliev, I., Peychev, L., et al. (2020). Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review. Polymers , 12 (10), 2338. MDPI AG. Retrieved from http://dx.doi.org/10.3390/polym
2. Bi, D., Yu, B., Han, Q., Lu, J., White, W. L., Lai, Q., Cai, N., Luo, W., Gu, L., Li, S., Xu, H., Hu, Z., Nie, S., & Xu, X. (2018). Immune Activation of RAW264.7 Macrophages by Low Molecular Weight Fucoidan Extracted from New Zealand Undaria pinnatifida. Journal of agricultural and food chemistry , 66 (41), 10721–10728. https://doi.org/10.1021/acs.jafc.8b
3. Pradhan, B., Patra, S., Nayak, R., Behera, C., Dash, S. R., Nayak, S., Sahu, B. B., Bhutia, S. K., & Jena, M. (2020). Multifunctional role of fucoidan, sulfated polysaccharides in human health and disease: A journey under the sea in pursuit of potent therapeutic agents. International Journal of Biological Macromolecules, 164, 4263-4278. https://doi.org/https://doi.org/10.1016/j.ijbiomac.2020.09.

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