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- Different species of Ephedra can be identified by observing the nature of (A) inner surface (B) outer surface (C) trichomes (D) scaly leaves
- Indian Rhubarb can be distinguished from Rhapontic Rhubarb by the fluorescene it emits under UV light. Indian Rhubarb gives (A) deep yellow (B) deep violet (C) orange (D) pale green
- Genetically modified species of Papaver namely Papaver bracteatum and Papaver orientale contain the predominant alkaloid (A) Morphine (B) Codeine (C) Thebaine (D) Narcotine
- Increased risk of atherosclerosis is associated with decreased serum levels of (A) LDL (B) HDL (C) Triglycerides (D) VLDL
- A peptide hormone which inhibits bone resorption and given as a nasal spray is (A) Cortisol (B) Alendronate (C) Calcitonin (D) Calcitriol
- An inorganic ion which is used prophylactically in bipolar depression is (A) Valproate (B) Lithium (C) Chromium (D) Valium
- A b-lactamase inhibitor which contains an 1-oxopenam structure is (A) Tazobactam sodium (B) Clavulanate potassium (C) Sulbactam sodium (D) Thienamycin
- Salbutamol is prepared from
- Antihypoprothrombinemic effect of one stereochemical form is two to five times more than others (A) (S)-(+)- Warfarin (B) R-(+)- Warfarin (C) (S)-(-)- Warfarin (D) (RS)- Warfarin
- Some of the organic reactions are catalysed by a product obtained from starch on
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treatment with amylase from Bacillus macerans. It is (A) Amylopectin (B) Amylose (C) Cellulose (D) Cyclodextrin
- Florentine receiver is used to separate the liquids based on (A) molecular weight (B) sedimentation rate (C) density (D) freezing point
- The official dissolution test apparatus contains cylindrical vessel and the lower edge of the blade is positioned from inside bottom of the vessel at (A) 18 to 22mm (B) 23 to 27mm (C) 20 to 24mm (D) 25 to 29mm
- As per Drugs and Cosmetics Act and Rules, the Good Manufacturing Practice is included under Schedule (A) W (B) P (C) S (D) M
- A substance used for modification of silica gel for reversed-phase TLC is (A) Benzene (B) Glycerine (C) Silicone oil (D) Ether
- In IR spectrum, the functional group region is from (A) 4000cm-1^ to 900cm-1^ (B) 4000cm-1^ to 1400cm- (C) 1400cm-1^ to 900cm-1^ (D) 4000cm-1^ to 660cm-
- The equation E= Eo + RT/ nF ln aM3+^ is used to measure the (A) Conductance (B) Potential difference (C) Resistance (D) Current
- Intermediates in the biosynthesis of cholesterol are (A) Mevalonic acid and isopentenyl pyrophosphate (B) Mevalonic acid and aldosterone (C) Isoprenaline and aldosterone (D) Isoprenaline and isopentenyl phosphate
- A naturally occurring amino acid which does not have a chiral centre is (A) Glycine (B) Alanine (C) Tryptophan (D) Tyrosine
- A given Gram-positive bacterium is differentiated from Gram-negative bacteria by Gram staining. This is because its cell wall contains (A) Lysozyme (B) Teichoic acid (C) Membrane proteins (D) Lipid A
- The drug which increases the plasma concentration of digoxin by a
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- Phenol, an antiseptic when treated as follows
OH
C 2 H 5 COCl
OCOC 2 H 5
AlCl 3 , CS 2
OH COC 2 H 5
OH
COC 2 H 5
gave the above two phenolic ketones. The reaction is (A) Hofmann rearrangement (B) Fries rearrangement (C) Kolbe’s reaction (D) Reimer-Tiemann reaction
- The quantity of drug required to make a 2% w/w solution in 240ml of alcohol is (The density of alcohol is 0.816 g/ml) (A) 1.632g (B) 2.400g (C) 4.000g (D) 4.800g
- In multistation punching machine, the upper as well as lower punches are connected by (A) Cams (B) Turrets (C) Wire meshes (D) Revolving belts
- As per the Drugs and Cosmetics Act, the HEPA filters are required to filter the air
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in the pharmaceutical manufacturing unit. Grade A filter is used for (A) Aseptic preparation and filling (B) Background room used for preliminary activities (C) Filtering liquid preparations (D) Handling of components after washing
- The deflection of positive ions formed in a mass spectrometer by electric and magnetic fields depends upon its (A) mass (B) charge (C) velocity (D) mass, charge and velocity
- Cyclohexane can be used as a solvent in UV spectrophotometric analysis because (A) It has a ring structure (B) Energy requirement for σ − σ* is in the range of 120-200nm (C) It is volatile (D) It is immiscible with water
- Quaternary structure in protein molecules refers to the (A) Arrangement of multiple domains in a single polypeptide chain (B) Specific arrangement of multiple subunits in multi-subunit proteins (C) Formation of molten globules (D) Protein folding in single subunit proteins
- Interleukins are (A) Polypeptide cytokines important in the inflammatory cascade (B) Prostaglandins that account for gastrointestinal disorders (C) Enkephalins which are specific for asthma (D) Dipeptides which have antimicrobial properties
- Phase I clinical studies of a drug under development is generally carried out on (A) At least 10,000 people from different ethnic communities and a wide range of age groups (B) A medium sized group of 500-1000 patients suffering from the disease for which the drug is being developed (C) A small group of 20-100 healthy male and female volunteers (D) Reliable in-vintro cell-lines derived from people suffering with the disease
- A young patient complains that he gets severe shortness of breath whenever he
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Q. Caspofungin 2. Topoisomerase II (DNA gyrase) the enzyme that produces a negative supercoil R. Aztreonam 3. The synthesis of b(1-2) glycan S. Rifabutin 4. Cell wall synthesis preferentially binding to a specific penicillin binding protein (A) P-2,Q-3,R-4,S-1 (B) P-3,Q-4,R-1,S- (C) P-4,Q-1,R-2,S-3 (D) P-1,Q-2,R-3,S-
- Group I Group II Drug Receptor agonist/antagonist P. Granisetron 1. β 1 adrenergic receptor antagonist Q. Pirenzepine 2. GABA agonist R. Acebutalol 3. 5HT 3 antagonist S. Baclofen 4. M 1 antagonist (A) P-1,Q-2,R-3,S-4 (B) P-3,Q-4,R-1,S- (C) P-2,Q-3,R-4,S-1 (D) P-4,Q-1,R-2,S-
- Group I Group II Drug Biotransformation P. Chlorpromazine 1. S-oxidation Q. Thioridazine 2. Microsomal hydroxylation R. Diazepam 3. Desulphuration S. Thiopentone 4. N-dealkylation (A) P-4,Q-1,R-2,S-3 (B) P-2,Q-3,R-4,S- (C) P-4,Q-3,R-2,S-1 (D) P-4,Q-2,R-3,S-
- Group I Group II Drug 7-Subtitution in 1, 3-dimethyl xanthine with
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- Group I Group II Equipment To determine P. Cascade Impactor 1. Flash point Q. Tag Open Cup apparatus 2. Sedimentation rate R. Pycnometer 3. Particle size S. Rheometer 4. Density of liquid (A) P-3,Q-1,R-4,S-2 (B) P-1,Q-3,R-2,S- (C) P-4,Q-2,R-3,S-1 (D) P-2,Q-3,R-1,S-
- Group I Group II Classification Penetration enhancer P. Ionic surfactant 1. Terpenes Q. Nonionic surfactant 2. Polyoxyethylene-20-cetyl ether R. Non surfactant 3. Polyethylene-9-lauryl ether S. Chelating agent 4. Citric acid (A) P-3,Q-2,R-1,S-4 (B) P-2,Q-3,R-1,S- (C) P-3,Q-4,R-1,S-2 (D) P-4,Q-2,R-3,S-
- Group I Group II Transdermal drug delivery system Method of penetration
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P. Competitive inhibitors 1. have affinity only for the [E-S] complex and not for the free [E] Q. Non-competitive inhibitors 2. binding of the inhibitor and that of the natural substrate are mutually exclusive R. Uncompetitive inhibitors 3. ultimately binds covalently to the enzyme S. Suicide inhibitors 4. binds with the same affinity to [E] and [E-S] (A) P-3,Q-2,R-1,S-4 (B) P-1,Q-3,R-2,S- (C) P-4,Q-1,R-3,S-2 (D) P-2,Q-4,R-1,S-
- Group I Group II Process Required molecules P. Post translation modification 1. Signal peptidase Q. DNA repair 2. Sigma factor R. Control of prokaryotic transcription 3. Proteasome complex S. Protein degradation 4. Photolyase (A) P-1,Q-4,R-2,S-3 (B) P-2,Q-3,R-1,S- (C) P-3,Q-2,R-4,S-1 (D) P-2,Q-1,R-3,S-
- Group I Group II Microorganism Typical characteristics P. Corynebacterium diptheriae 1. Cells divide in three planes in an irregular pattern, producing ‘bunches’ Q. Streptococcus pyogenes 2. Cells are lined side by side like matchsticks and at angles to one another R. Staphylococcus aureus 3. long, branched, multinuclear filaments called ‘hyphae’ S. Streptomyces viridochroma 4. cells divide in one plane and remain attached to form chain
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(A) P-3,Q-4,R-2,S-1 (B) P-4,Q-1,R-2,S-
(C) P-2,Q-4,R-1,S-3 (D) P-3,Q-2,R-1,S-
- Group I Group II Condition Description P. Agranulocytosis 1. Reduced lifespan of erythrocytes Q. Anisocytosis 2. Lack of neutrophils R. Aplastic anemia 3. Abnormal variation in RBC size S. Hemolytic anemia 4. Depression of synthesis of all cell types in bone marrow (A) P-2,Q-3,R-4,S-1 (B) P-2,Q-4,R-3,S- (C) P-1,Q-2,R-4,S-3 (D) P-4,Q-2,R-1,S- Common Data Questions: 51 & 52 Transgenic plants are developed by genetic engineering techniques
- The method involves (A) Individual genes from one species inserted into another; the offspring will contain copies of new gene. (B) By crossing two species or varieties differing at least in one set of characters (C) Exposing the plant tissue to radiation (D) Bioproduction of natural compounds under aseptic conditions
- In the production of transgenic plants, the gene transfer is carried out by (A) Induction of meristematic primordial (B) Gel filtration (C) Clonal propagation (D) Silicon carbide whiskers
- In the design of Captopril, the (A) -COOH group is introduced in proline to enhance the binding capability at the receptor site (B) -SH group is introduced to enhance the binding capability of the drug with cobalt ion of ACE (C) -SH group is introduced to enhance the binding to the zinc ion of ACE (D) -COOH and –SH groups to introduce hydrophilic pockets at the receptor site
- Captopril IP is assayed by titration (A) against 0.1N sodium hydroxide using phenolphthalein indicator
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(D) Forming hydrogen peroxide which generates free radicals Statement for Linked Answer Questions: 59 & 60 The compound A combined with X to get converted into B, in the presence of an appropriate enzyme
H 2 N
0H
COOH
O
HN
O O
OH
OH
OH
COOH
OH
- The reaction can be described as (A) Bioactivation (B) Glucuronide conjugation (C) b-Oxidation (D) Stereospecific glycine conjugation
- The significance of the above reaction in drug therapy is that the reaction (A) Converts water soluble compound into a lipid soluble compound, thereby increasing its potency (B) Converts an uncharged species into a charged species, increasing the shelflife of the compound (C) Adds an ionic hydrophilic moiety, facilitating its urinary elimination (D) Adds a bulky substituent to convert it into an active compound
Pharmacophore Solutions
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