PATOGENIA DE
LA PSORIASIS
R1 CRISELY
GONZALEZ
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Pathogenesis of Psoriasis: A Comprehensive Overview, Summaries of Medicine
A detailed overview of the pathogenesis of psoriasis, a chronic inflammatory skin disease. It explores the role of keratinocytes, t lymphocytes, genetic factors, and inflammatory mediators in the development and progression of psoriasis. The document also discusses the involvement of the vascular system and the mechanisms of pruritus associated with psoriasis. It is a valuable resource for students and professionals in the field of dermatology and immunology.
Typology: Summaries
2023/2024
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PATOGENIA DE
LA PSORIASIS
R1 CRISELY
GONZALEZ
LA PIEL
- (^) Protección
- (^) Mantiene Temperatura
- Órgano sensorial
- (^) Función inmune
- (^) Epidermis ( 4 estratos)
- (^) Dermis (Melanocitos,
CD4, CD8, NK,
Células dendríticas)
Michelle A, Lowes A, James G, et al. Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
TIPOS DE RESPUESTAS DE LINFOCITOS T CD Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
PSORIASIS Proliferación de queratinocitos genéticamente predispuestos, se diferencian en 4 días. Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
PEPTIDO ANTIMICROBIANO CATHELICIDINA (hCAP18/LL-37) Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
ACTIVACION DE LOS LINFOCITOS T EN PSORIASIS Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
MECANISMOS DE CONTROL INFLAMATORIO EN PSORIASIS Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
COMPONENTE VASCULAR EN PSORIASIS
- (^) Neoangiogenesis
- Hipoxia
- Factor vascular endotelial
- (^) Vasos dilatados, tortuosos
- (^) Mayor permeabilidad
- (^) Se identifica al inicio de la psoriasis
- (^) Predisposición genética Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical
MEDIADORES DEL PRURITO EN PSORIASIS
Receptores activados por Proteasas Sustancia P
Relación funcional entre los mastocitos
cutáneos y terminaciones neuronales
aferentes C en la piel
Triptasa y quimasa
La triptasa estimula al receptor PAR-
de las terminaciones nerviosas C, que
transmiten la información al SNC y
producen el prurito.
Liberación de Neuropéptidos (sustancia
P)
Comunicación directa entre los
mastocitos y las fibras nerviosas.
Bajas concentraciones de sustancias P
activan a los receptores NK1 de los
mastocitos sensibilizándolos y
aumentando la producción de TNFa
que sensibiliza las terminaciones
nerviosas nociceptivas
Michelle A, Lowes A, James G, et al.Pathogenesis and therapy of psoriasis. NATURE. 2007, 445: 22 Nickoloff B, Nestle F, Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004, 113:1664– Abril W, Charlotte Read, Fisiopatología, presentación clínica y tratamiento de la psoriasis Una revisión. Journal American Medical